Flexibility defines structure in crystals of amphiphilic DNA nanostars.
| cam.issuedOnline | 2018-11-28 | |
| dc.contributor.author | Brady, Ryan A | |
| dc.contributor.author | Kaufhold, Will T | |
| dc.contributor.author | Brooks, Nicholas J | |
| dc.contributor.author | Foderà, Vito | |
| dc.contributor.author | Di Michele, Lorenzo | |
| dc.contributor.orcid | Di Michele, Lorenzo [0000-0002-1458-9747] | |
| dc.date.accessioned | 2018-12-22T00:30:56Z | |
| dc.date.available | 2018-12-22T00:30:56Z | |
| dc.date.issued | 2019-02-20 | |
| dc.description.abstract | DNA nanostructures with programmable shape and interactions can be used as building blocks for the self-assembly of crystalline materials with prescribed nanoscale features, holding a vast technological potential. Structural rigidity and bond directionality have been recognised as key design features for DNA motifs to sustain long-range order in 3D, but the practical challenges associated with prescribing building-block geometry with sufficient accuracy have limited the variety of available designs. We have recently introduced a novel platform for the one-pot preparation of crystalline DNA frameworks supported by a combination of Watson-Crick base pairing and hydrophobic forces (Brady et al 2017 Nano Lett. 17 3276-81). Here we use small angle x-ray scattering and coarse-grained molecular simulations to demonstrate that, as opposed to available all-DNA approaches, amphiphilic motifs do not rely on structural rigidity to support long-range order. Instead, the flexibility of amphiphilic DNA building-blocks is a crucial feature for successful crystallisation. | |
| dc.format.medium | Print-Electronic | |
| dc.identifier.doi | 10.17863/CAM.34688 | |
| dc.identifier.eissn | 1361-648X | |
| dc.identifier.issn | 0953-8984 | |
| dc.identifier.uri | https://www.repository.cam.ac.uk/handle/1810/287384 | |
| dc.language | eng | |
| dc.language.iso | eng | |
| dc.publisher | IOP Publishing | |
| dc.publisher.url | http://dx.doi.org/10.1088/1361-648X/aaf4a1 | |
| dc.subject | Biomechanical Phenomena | |
| dc.subject | Crystallography, X-Ray | |
| dc.subject | DNA | |
| dc.subject | Hydrophobic and Hydrophilic Interactions | |
| dc.subject | Models, Molecular | |
| dc.subject | Nanostructures | |
| dc.subject | Nucleic Acid Conformation | |
| dc.title | Flexibility defines structure in crystals of amphiphilic DNA nanostars. | |
| dc.type | Article | |
| prism.issueIdentifier | 7 | |
| prism.publicationDate | 2019 | |
| prism.publicationName | J Phys Condens Matter | |
| prism.startingPage | 074003 | |
| prism.volume | 31 | |
| pubs.funder-project-id | EPSRC (1494571) | |
| pubs.funder-project-id | Engineering and Physical Sciences Research Council (EP/L015978/1) | |
| rioxxterms.licenseref.startdate | 2019-02 | |
| rioxxterms.licenseref.uri | http://www.rioxx.net/licenses/all-rights-reserved | |
| rioxxterms.type | Journal Article/Review | |
| rioxxterms.version | AM | |
| rioxxterms.versionofrecord | 10.1088/1361-648X/aaf4a1 |
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