Flexibility defines structure in crystals of amphiphilic DNA nanostars.

cam.issuedOnline2018-11-28
dc.contributor.authorBrady, Ryan A
dc.contributor.authorKaufhold, Will T
dc.contributor.authorBrooks, Nicholas J
dc.contributor.authorFoderà, Vito
dc.contributor.authorDi Michele, Lorenzo
dc.contributor.orcidDi Michele, Lorenzo [0000-0002-1458-9747]
dc.date.accessioned2018-12-22T00:30:56Z
dc.date.available2018-12-22T00:30:56Z
dc.date.issued2019-02-20
dc.description.abstractDNA nanostructures with programmable shape and interactions can be used as building blocks for the self-assembly of crystalline materials with prescribed nanoscale features, holding a vast technological potential. Structural rigidity and bond directionality have been recognised as key design features for DNA motifs to sustain long-range order in 3D, but the practical challenges associated with prescribing building-block geometry with sufficient accuracy have limited the variety of available designs. We have recently introduced a novel platform for the one-pot preparation of crystalline DNA frameworks supported by a combination of Watson-Crick base pairing and hydrophobic forces (Brady et al 2017 Nano Lett. 17 3276-81). Here we use small angle x-ray scattering and coarse-grained molecular simulations to demonstrate that, as opposed to available all-DNA approaches, amphiphilic motifs do not rely on structural rigidity to support long-range order. Instead, the flexibility of amphiphilic DNA building-blocks is a crucial feature for successful crystallisation.
dc.format.mediumPrint-Electronic
dc.identifier.doi10.17863/CAM.34688
dc.identifier.eissn1361-648X
dc.identifier.issn0953-8984
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/287384
dc.languageeng
dc.publisherIOP Publishing
dc.publisher.urlhttp://dx.doi.org/10.1088/1361-648X/aaf4a1
dc.subjectBiomechanical Phenomena
dc.subjectCrystallography, X-Ray
dc.subjectDNA
dc.subjectHydrophobic and Hydrophilic Interactions
dc.subjectModels, Molecular
dc.subjectNanostructures
dc.subjectNucleic Acid Conformation
dc.titleFlexibility defines structure in crystals of amphiphilic DNA nanostars.
dc.typeArticle
prism.issueIdentifier7
prism.publicationDate2019
prism.publicationNameJ Phys Condens Matter
prism.startingPage074003
prism.volume31
pubs.funder-project-idEPSRC (1494571)
pubs.funder-project-idEngineering and Physical Sciences Research Council (EP/L015978/1)
rioxxterms.licenseref.startdate2019-02
rioxxterms.licenseref.urihttp://www.rioxx.net/licenses/all-rights-reserved
rioxxterms.typeJournal Article/Review
rioxxterms.versionAM
rioxxterms.versionofrecord10.1088/1361-648X/aaf4a1
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