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Cohort profile of the Biomarkers of Acute Serious Illness in Children (BASIC) study: a prospective multicentre cohort study in critically ill children.

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cam.issuedOnline2018-11-08
dc.contributor.authorFeinstein, Yael
dc.contributor.authorWalker, Jennifer Claire
dc.contributor.authorPeters, Mark J
dc.contributor.authorNadel, Simon
dc.contributor.authorPathan, Nazima
dc.contributor.authorEdmonds, Naomi
dc.contributor.authorHerberg, Jethro
dc.contributor.authorKaforou, Myrsini
dc.contributor.authorWright, Victoria
dc.contributor.authorLevin, Michael
dc.contributor.authorRamnarayan, Padmanabhan
dc.contributor.orcidPathan, Nazima [0000-0002-9447-4252]
dc.contributor.orcidRamnarayan, Padmanabhan [0000-0003-0784-8154]
dc.date.accessioned2018-12-13T00:33:08Z
dc.date.available2018-12-13T00:33:08Z
dc.date.issued2018-11-08
dc.description.abstractPURPOSE: Despite significant progress, challenges remain in the management of critically ill children, including early identification of infection and organ failure and robust early risk stratification to predict poor outcome. The Biomarkers of Acute Serious Illness in Children study aims to identify genetic and biological pathways underlying the development of critical illness in infections and organ failure and those leading to poor outcome (death or severe disability) in children requiring emergency intensive care. PARTICIPANTS: We recruited a prospective cohort of critically ill children undergoing emergency transport to four paediatric intensive care units (PICUs) in Southeast England between April 2014 and December 2016. FINDINGS TO DATE: During the study period, 1017 patients were recruited by the regional PICU transport team, and blood and urine samples were obtained at/around first contact with the patient by the transport team. Consent for participation in the study was deferred until after PICU admission and 674 parents/carers were consented. Further samples (blood, urine, stool and throat swabs) were collected after consent. Samples were processed and stored for genomic, transcriptomic, proteomic and metabolomic analyses. Demographic, clinical and laboratory data at first contact, during PICU stay and at discharge, were collected, as were detailed data regarding infectious or non-infectious aetiology. In addition, 115 families have completed 12-month validated follow-up questionnaires to assess quality of life and child behaviour.The first phase of sample analyses (transcriptomic profiling) is currently in progress. FUTURE PLANS: Stored samples will be analysed using genomic, proteomic and metabolic profiling. Advanced bioinformatics techniques will be used to identify biomarkers for early diagnosis of infection, identification of organ failure and risk stratification to predict poor outcome (death/severe disability). TRIAL REGISTRATION NUMBER: NCT03238040.
dc.description.sponsorshipGreat Ormond St Hospital Childrens Charity
dc.format.mediumElectronic
dc.identifier.doi10.17863/CAM.34168
dc.identifier.eissn2044-6055
dc.identifier.issn2044-6055
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/286862
dc.languageeng
dc.language.isoeng
dc.publisherBMJ
dc.publisher.urlhttp://dx.doi.org/10.1136/bmjopen-2018-024729
dc.rightsAttribution-NonCommercial 4.0 International
dc.rights.urihttps://creativecommons.org/licenses/by-nc/4.0/
dc.subjectbiomarkers
dc.subjectchildren
dc.subjectmulti-omics
dc.subjectretreival
dc.subjectAcute Disease
dc.subjectAdolescent
dc.subjectBacterial Infections
dc.subjectBiomarkers
dc.subjectChild
dc.subjectChild, Preschool
dc.subjectCohort Studies
dc.subjectCritical Care
dc.subjectCritical Illness
dc.subjectEmergency Medical Services
dc.subjectEngland
dc.subjectFemale
dc.subjectFollow-Up Studies
dc.subjectHumans
dc.subjectInfant
dc.subjectInfant, Newborn
dc.subjectMale
dc.subjectMultiple Organ Failure
dc.subjectProspective Studies
dc.titleCohort profile of the Biomarkers of Acute Serious Illness in Children (BASIC) study: a prospective multicentre cohort study in critically ill children.
dc.typeArticle
dcterms.dateAccepted2018-09-26
prism.issueIdentifier11
prism.publicationDate2018
prism.publicationNameBMJ Open
prism.startingPagee024729
prism.volume8
pubs.funder-project-idEuropean Society of Intensive Care Medicine (ESICM) (ECCRN AWARD 2013)
pubs.funder-project-idEvelyn Trust (14/19)
rioxxterms.licenseref.startdate2018-11-08
rioxxterms.licenseref.urihttp://www.rioxx.net/licenses/all-rights-reserved
rioxxterms.typeJournal Article/Review
rioxxterms.versionVoR
rioxxterms.versionofrecord10.1136/bmjopen-2018-024729

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