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Drosophila intestinal stem and progenitor cells are major sources and regulators of homeostatic niche signals.

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cam.issuedOnline2018-11-07
dc.contributor.authorDoupé, David P
dc.contributor.authorMarshall, Owen J
dc.contributor.authorDayton, Hannah
dc.contributor.authorBrand, Andrea H
dc.contributor.authorPerrimon, Norbert
dc.contributor.orcidBrand, Andrea [0000-0002-2089-6954]
dc.date.accessioned2018-12-11T00:31:47Z
dc.date.available2018-12-11T00:31:47Z
dc.date.issued2018-11-27
dc.description.abstractEpithelial homeostasis requires the precise balance of epithelial stem/progenitor proliferation and differentiation. While many signaling pathways that regulate epithelial stem cells have been identified, it is probable that other regulators remain unidentified. Here, we use gene-expression profiling by targeted DamID to identify the stem/progenitor-specific transcription and signaling factors in the Drosophila midgut. Many signaling pathway components, including ligands of most major pathways, exhibit stem/progenitor-specific expression and have regulatory regions bound by both intrinsic and extrinsic transcription factors. In addition to previously identified stem/progenitor-derived ligands, we show that both the insulin-like factor Ilp6 and TNF ligand eiger are specifically expressed in the stem/progenitors and regulate normal tissue homeostasis. We propose that intestinal stem cells not only integrate multiple signals but also contribute to and regulate the homeostatic signaling microenvironmental niche through the expression of autocrine and paracrine factors.
dc.format.mediumPrint-Electronic
dc.identifier.doi10.17863/CAM.33965
dc.identifier.eissn1091-6490
dc.identifier.issn0027-8424
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/286653
dc.languageeng
dc.language.isoeng
dc.publisherProceedings of the National Academy of Sciences
dc.publisher.urlhttp://dx.doi.org/10.1073/pnas.1719169115
dc.rightsAttribution 4.0 International
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.subjectepithelial homeostasis
dc.subjectinsulin
dc.subjectmicroenvironment
dc.subjectniche
dc.subjectstem cells
dc.subjectAnimals
dc.subjectDrosophila
dc.subjectDrosophila Proteins
dc.subjectHomeostasis
dc.subjectIntestines
dc.subjectSignal Transduction
dc.subjectStem Cell Niche
dc.subjectStem Cells
dc.titleDrosophila intestinal stem and progenitor cells are major sources and regulators of homeostatic niche signals.
dc.typeArticle
dcterms.dateAccepted2018-10-11
prism.endingPage12223
prism.issueIdentifier48
prism.publicationDate2018
prism.publicationNameProc Natl Acad Sci U S A
prism.startingPage12218
prism.volume115
pubs.funder-project-idWellcome Trust (092545/Z/10/Z)
pubs.funder-project-idBiotechnology and Biological Sciences Research Council (BB/L00786X/1)
pubs.funder-project-idWellcome Trust (103792/Z/14/Z)
pubs.funder-project-idWellcome Trust (092096/Z/10/Z)
pubs.funder-project-idCancer Research Uk (None)
rioxxterms.licenseref.startdate2018-11-07
rioxxterms.licenseref.urihttp://www.rioxx.net/licenses/all-rights-reserved
rioxxterms.typeJournal Article/Review
rioxxterms.versionVoR
rioxxterms.versionofrecord10.1073/pnas.1719169115

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