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The Role of Placental Hormones in Mediating Maternal Adaptations to Support Pregnancy and Lactation.

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cam.issuedOnline2018-08-17
dc.contributor.authorNapso, Tina
dc.contributor.authorYong, Hannah EJ
dc.contributor.authorLopez-Tello, Jorge
dc.contributor.authorSferruzzi-Perri, Amanda N
dc.contributor.orcidSferruzzi-Perri, Amanda [0000-0002-4931-4233]
dc.date.accessioned2018-11-23T00:32:06Z
dc.date.available2018-11-23T00:32:06Z
dc.date.issued2018
dc.description.abstractDuring pregnancy, the mother must adapt her body systems to support nutrient and oxygen supply for growth of the baby in utero and during the subsequent lactation. These include changes in the cardiovascular, pulmonary, immune and metabolic systems of the mother. Failure to appropriately adjust maternal physiology to the pregnant state may result in pregnancy complications, including gestational diabetes and abnormal birth weight, which can further lead to a range of medically significant complications for the mother and baby. The placenta, which forms the functional interface separating the maternal and fetal circulations, is important for mediating adaptations in maternal physiology. It secretes a plethora of hormones into the maternal circulation which modulate her physiology and transfers the oxygen and nutrients available to the fetus for growth. Among these placental hormones, the prolactin-growth hormone family, steroids and neuropeptides play critical roles in driving maternal physiological adaptations during pregnancy. This review examines the changes that occur in maternal physiology in response to pregnancy and the significance of placental hormone production in mediating such changes.
dc.format.mediumElectronic-eCollection
dc.identifier.doi10.17863/CAM.33149
dc.identifier.eissn1664-042X
dc.identifier.issn1664-042X
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/285805
dc.languageeng
dc.language.isoeng
dc.publisherFrontiers Media SA
dc.publisher.urlhttp://dx.doi.org/10.3389/fphys.2018.01091
dc.rightsAttribution 4.0 International
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.subjectcardiovascular
dc.subjectendocrine
dc.subjectfetal growth
dc.subjecthormones
dc.subjectmaternal adaptations
dc.subjectmetabolism
dc.subjectplacenta
dc.subjectpregnancy
dc.titleThe Role of Placental Hormones in Mediating Maternal Adaptations to Support Pregnancy and Lactation.
dc.typeArticle
dcterms.dateAccepted2018-07-23
prism.publicationDate2018
prism.publicationNameFront Physiol
prism.startingPage1091
prism.volume9
pubs.funder-project-idEuropean Commission Horizon 2020 (H2020) Marie Sk?odowska-Curie actions (700999)
pubs.funder-project-idSociety for Endocrinology (Unknown)
rioxxterms.licenseref.startdate2018-01
rioxxterms.licenseref.urihttp://www.rioxx.net/licenses/all-rights-reserved
rioxxterms.typeJournal Article/Review
rioxxterms.versionVoR
rioxxterms.versionofrecord10.3389/fphys.2018.01091

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