Tracing cellular dynamics in tissue development, maintenance and disease.


Type
Article
Change log
Authors
Simons, Benjamin D 
Abstract

The coordination of cell proliferation and differentiation is central to the development and maintenance of tissues, while its dysregulation underlies the transition to diseased states. By combining lineage tracing with transcriptional profiling and marker-based assays, statistical methods are delivering insights into the dynamics of stem cells and their developmental precursors. These studies have provided evidence for molecular heterogeneity and fate priming, and have revealed a role for stochasticity in stem cell fate, refocusing the search for regulatory mechanisms. At the same time, they present a quantitative platform to study the initiation and progression of disease. Here, we review how quantitative lineage tracing strategies are shaping our understanding of the cellular mechanisms of tissue development, maintenance and disease.

Description
Keywords
Animals, Cell Differentiation, Cell Lineage, Cells, Disease, Humans, Organogenesis, Stem Cells
Journal Title
Curr Opin Cell Biol
Conference Name
Journal ISSN
0955-0674
1879-0410
Volume Title
43
Publisher
Elsevier BV
Sponsorship
Wellcome Trust (098357/Z/12/Z)
Medical Research Council (MC_PC_12009)