Chemoselective Continuous Ru-Catalyzed Hydrogen-transfer Oppenauer-type Oxidation of Secondary Alcohols
Accepted version
Peer-reviewed
Repository URI
Repository DOI
Change log
Authors
Abstract
A continuous flow method for the selective oxidation of secondary alcohols is reported. The method is based on an Oppenauer-type ruthenium-catalyzed hydrogen-transfer process that uses acetone as both solvent and oxidant. The process utilizes a low loading (1 mol%) of the commercially available ruthenium catalyst [Ru(p-cymene)Cl₂]₂and triethylamine as a base and can be successfully applied to a range of different substrates, with a good level of functional group tolerance.
Description
Journal Title
Organic Process Research and Development
Conference Name
Journal ISSN
1083-6160
1520-586X
1520-586X
Volume Title
21
Publisher
American Chemical Society
Publisher DOI
Rights and licensing
Except where otherwised noted, this item's license is described as All rights reserved
Sponsorship
Engineering and Physical Sciences Research Council (EP/K009494/1)
Engineering and Physical Sciences Research Council (EP/M004120/1)
Engineering and Physical Sciences Research Council (EP/K039520/1)
Engineering and Physical Sciences Research Council (EP/M004120/1)
Engineering and Physical Sciences Research Council (EP/K039520/1)
The authors are grateful to Eli Lilly & Co. (RL) and the EPSRC (SVL, grants EP/K009494/1, EP/M004120/1, and EP/K039520/1) for financial support. This work was supported by Eli Lilly & Co. through the Lilly Research Award Program (LRAP).