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Using Solid Catalysts in Disulfide-Based Dynamic Combinatorial Solution- and Mechanochemistry.

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cam.depositDate2021-12-07
cam.issuedOnline2021-12-23
cam.orpheus.success2021-12-22 - Embargo set during processing via Fast-track
dc.contributor.authorBelenguer, Ana M
dc.contributor.authorMichalchuk, Adam AL
dc.contributor.authorLampronti, Giulio I
dc.contributor.authorSanders, Jeremy KM
dc.contributor.orcidBelenguer, Ana M [0000-0002-0443-4856]
dc.contributor.orcidMichalchuk, Adam AL [0000-0001-7405-3269]
dc.contributor.orcidLampronti, Giulio I [0000-0002-1430-3446]
dc.contributor.orcidSanders, Jeremy KM [0000-0002-5143-5210]
dc.date.accessioned2021-12-23T00:30:25Z
dc.date.available2021-12-23T00:30:25Z
dc.date.issued2022-02-08
dc.date.updated2021-12-07T13:53:10Z
dc.description.abstractIt was shown for the first time that solid amines can act as catalysts for disulfide-based dynamic combinatorial chemistry (DCC) by ball mill grinding. The mechanochemical equilibrium for the two disulfide reactions studied was reached within 1-3 h using ten different amine catalysts. This contrasts with the weeks to months to achieve solution equilibrium for most solid amine catalysts at 2 %mol mol-1 concentration in a 2 mMolar disulfide dynamic combinatorial library in a suitable solvent. The final mechanochemical equilibrium was independent of the catalyst used but varied with other ball mill grinding factors such as the presence of traces of solvent. The different efficiencies of the amines tested were discussed.
dc.identifier.doi10.17863/CAM.79179
dc.identifier.eissn1864-564X
dc.identifier.issn1864-5631
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/331730
dc.language.isoeng
dc.publisherWiley
dc.publisher.departmentDepartment of Chemistry
dc.publisher.urlhttp://dx.doi.org/10.1002/cssc.202102416
dc.rightsAll Rights Reserved
dc.rights.urihttp://www.rioxx.net/licenses/all-rights-reserved
dc.subjectball milling
dc.subjectdisulfide exchange
dc.subjectdynamic covalent chemistry
dc.subjectmechanochemistry
dc.subjectsolid amine catalysts
dc.subjectCatalysis
dc.subjectDisulfides
dc.subjectSolvents
dc.titleUsing Solid Catalysts in Disulfide-Based Dynamic Combinatorial Solution- and Mechanochemistry.
dc.typeArticle
dcterms.dateAccepted2021-12-03
prism.publicationNameChemSusChem
pubs.licence-display-nameApollo Repository Deposit Licence Agreement
pubs.licence-identifierapollo-deposit-licence-2-1
rioxxterms.typeJournal Article/Review
rioxxterms.versionAM
rioxxterms.versionofrecord10.1002/cssc.202102416

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