Cardiovascular and skeletal muscle manifestations constitute important comorbidities in COPD, with systemic inflammation proposed as a common mechanistic link. Fibrinogen has prognostic role in COPD. We aimed to determine whether aortic stiffness and quadriceps weakness are linked in COPD, and whether they are associated with the systemic inflammatory mediator – fibrinogen. Aortic pulse wave velocity (aPWV), quadriceps maximal volitional contraction force (QMVC) and fibrinogen were measured in 729, stable, GOLD stage II-IV COPD patients. The cardiovascular and muscular manifestations exist independently (p=0.22, Chi squared). Fibrinogen was not associated with aPWV or QMVC (p=0.628 and p=0.621 respectively), making inflammation, as measured by plasma fibrinogen, an unlikely common aetiological factor.