Data are results from experiments in which we measured phenotypes including weight, adiposity, food motivation, blood pressure, energy expenditure in Labrador and flatcoat retriever dogs with and without a mutation in the gene POMC which was previously described in Raffan 2016 (PMID: 27157046). Each worksheet in the excel file can be exported as plain text for analysis with accompanying code. In addition there is a README tab with experimenter contact information, and a Participation Summary sheet which shows which dogs took part in the different experiments. FCR_epi and RCR_epi_readme: Flatcoat retriever epidemiology information and data. EndocrineTests: Results of ACTH, TT4, TSH BP: Blood pressure data EnergyExp: indirect calorimetry data from FCR FoodPreference, AdLibitum, IncentiveSalience: data from different eating behaviour experiments.