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You won't believe this old test … that does cheap single-cell mutation detection.

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cam.issuedOnline2018-07-30
dc.contributor.authorKöbel, Martin
dc.contributor.authorAnglesio, Michael S
dc.contributor.authorBrenton, James D
dc.contributor.orcidKöbel, Martin [0000-0002-6615-2037]
dc.contributor.orcidAnglesio, Michael S [0000-0003-1639-5003]
dc.date.accessioned2018-11-14T00:31:36Z
dc.date.available2018-11-14T00:31:36Z
dc.date.issued2018-07
dc.description.abstractDetecting mutations in single cells from cancer specimens is now a major area of translational research. In a recent article in this journal, Khalique et al validated an immunohistochemistry assay for ARID1A that reliably identifies loss of function mutations in single cells in tissue sections. This work exemplifies best practice for developing and orthogonally validating immunohistochemical assays to provide clearly interpretable mutational results with spatial context.
dc.format.mediumPrint
dc.identifier.doi10.17863/CAM.32426
dc.identifier.eissn2056-4538
dc.identifier.issn2056-4538
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/285056
dc.languageeng
dc.language.isoeng
dc.publisherWiley
dc.publisher.urlhttp://dx.doi.org/10.1002/cjp2.108
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 International
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/4.0/
dc.subjectFemale reproductive system
dc.subjectImmunohistochemistry
dc.subjectMutation
dc.subjectOvary
dc.subjectTesting
dc.subjectDNA-Binding Proteins
dc.subjectFemale
dc.subjectGenital Neoplasms, Female
dc.subjectHumans
dc.subjectImmunohistochemistry
dc.subjectMutation
dc.subjectNuclear Proteins
dc.subjectTranscription Factors
dc.titleYou won't believe this old test … that does cheap single-cell mutation detection.
dc.typeArticle
dcterms.dateAccepted2018-07-10
prism.endingPage153
prism.issueIdentifier3
prism.publicationDate2018
prism.publicationNameJ Pathol Clin Res
prism.startingPage149
prism.volume4
pubs.funder-project-idCancer Research UK (CB4150)
pubs.funder-project-idCancer Research UK (C14303/A17197)
rioxxterms.licenseref.startdate2018-07
rioxxterms.licenseref.urihttp://www.rioxx.net/licenses/all-rights-reserved
rioxxterms.typeJournal Article/Review
rioxxterms.versionVoR
rioxxterms.versionofrecord10.1002/cjp2.108

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