These data have been generated as part of research projects aiming to characterise better the interplay between innate and adaptive immune systems. in particular, these data show that the Nod-like receptor (NLR) of the immune system NLRC4, which recognises microbial flagellin, downregulate the CD4+ T cell-mediated responses against the important zoonotic pathogen Salmonella Typhimurium in mice. Most importantly, we show that mice immunised with Salmonella that largely evades NLRC4 activation are better protected to a secondary lethal challenge, a finding with important implications for vaccine development against pathogens that activate NLRC4. Most of the data were generated after performing animal experiments in which wild type and certain NLR- and cytokine-deficient trangenic mice were challenged by Salmonella Typhimurium and their tissues /cells were interrogated ex vivo with microbiological and immunological methods. Some data has been generated by in vitro experiments in which murine bone marrow-derived macrophages were infected with Salmonella Typhimurium and their ability to lyse and secrete cytokines was assessed by classical biochemical and immunological methods.