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Prenatal depression, fetal neurobehavior, and infant temperament: Novel insights on early neurodevelopment from a socioeconomically disadvantaged Indian cohort.

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cam.issuedOnline2018-08-02
dc.contributor.authorFernandes, M
dc.contributor.authorSrinivasan, K
dc.contributor.authorMenezes, G
dc.contributor.authorRamchandani, PG
dc.contributor.orcidRamchandani, Paul [0000-0003-3646-2410]
dc.date.accessioned2018-10-03T04:45:00Z
dc.date.available2018-10-03T04:45:00Z
dc.date.issued2018-08
dc.description.abstractThis article extends the research focusing on the early origins of psychopathology into the prenatal period, by exploring the association between maternal prenatal depression and offspring (fetal and infant) neurobehavior. The sample is recruited from a rural population in South India where women in the third trimester of pregnancy were assessed for depression and the heart rate responses of their fetuses to extrinsically applied vibroacoustic stimuli were studied. At 2 months postbirth, infant temperament and cortisol responsivity to immunization were assessed. The association between maternal prenatal depression and fetal responsivity to vibroacoustic stimulation, and infant responsivity to immunization, was U shaped with higher levels of responsivity noted in the offspring of mothers with very high and very low depression scores, and lower levels noted in the offspring of mothers with moderate depression scores. Maternal prenatal depression was not associated with infant temperament. The findings highlight the importance of environmental influences in the developmental origins of neurobehavior, suggesting that such differences, not evident at baseline, may emerge upon exposure to stressors. The study also emphasizes the need for further investigation in low- and middle-income contexts by providing preliminary evidence of the differing patterns of association observed between high- and low-income populations.
dc.format.mediumPrint
dc.identifier.doi10.17863/CAM.30440
dc.identifier.eissn1469-2198
dc.identifier.issn0954-5794
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/283078
dc.languageeng
dc.language.isoeng
dc.publisherCambridge University Press (CUP)
dc.publisher.urlhttp://dx.doi.org/10.1017/s0954579418000615
dc.subjectAdult
dc.subjectCohort Studies
dc.subjectDepressive Disorder
dc.subjectFemale
dc.subjectHumans
dc.subjectHydrocortisone
dc.subjectIndia
dc.subjectInfant
dc.subjectInfant, Newborn
dc.subjectNeurodevelopmental Disorders
dc.subjectPoverty
dc.subjectPregnancy
dc.subjectPregnancy Complications
dc.subjectPrenatal Exposure Delayed Effects
dc.subjectRural Population
dc.subjectTemperament
dc.subjectVulnerable Populations
dc.titlePrenatal depression, fetal neurobehavior, and infant temperament: Novel insights on early neurodevelopment from a socioeconomically disadvantaged Indian cohort.
dc.typeArticle
dcterms.dateAccepted2018-05-22
prism.endingPage742
prism.issueIdentifier3
prism.publicationDate2018
prism.publicationNameDev Psychopathol
prism.startingPage725
prism.volume30
rioxxterms.licenseref.startdate2018-08
rioxxterms.licenseref.urihttp://www.rioxx.net/licenses/all-rights-reserved
rioxxterms.typeJournal Article/Review
rioxxterms.versionAM
rioxxterms.versionofrecord10.1017/S0954579418000615

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