Using Peptidomimetics and Constrained Peptides as Valuable Tools for Inhibiting Proteinā»Protein Interactions.
Published version
Peer-reviewed
Repository URI
Repository DOI
Change log
Authors
Robertson, Naomi S https://orcid.org/0000-0001-5519-9158
Spring, David R https://orcid.org/0000-0001-7355-2824
Abstract
Proteinā»protein interactions (PPIs) are tremendously important for the function of many biological processes. However, because of the structure of many proteinā»protein interfaces (flat, featureless and relatively large), they have largely been overlooked as potential drug targets. In this review, we highlight the current tools used to study the molecular recognition of PPIs through the use of different peptidomimetics, from small molecules and scaffolds to peptides. Then, we focus on constrained peptides, and in particular, ways to constrain Ī±-helices through stapling using both one- and two-component techniques.
Description
Keywords
macrocycles, peptidomimetics, proteināprotein interactions, proteomimetics, stapled peptides, Peptides, Peptidomimetics, Protein Binding
Journal Title
Molecules
Conference Name
Journal ISSN
1420-3049
1420-3049
1420-3049
Volume Title
23
Publisher
MDPI AG
Publisher DOI
Sponsorship
Engineering and Physical Sciences Research Council (EP/J016012/1)
Royal Society (WM150022)
Engineering and Physical Sciences Research Council (EP/P020291/1)
Royal Society (WM150022)
Engineering and Physical Sciences Research Council (EP/P020291/1)