MicroRNA-101 expression is associated with JAK2V617F activity and regulates JAK2/STAT5 signaling.


Type
Article
Change log
Authors
Pagano, Francesca 
Comoglio, Federico 
Grinfeld, Jacob 
Li, Juan 
Godfrey, Anna 
Abstract

Philadelphia negative myeloproliferative neopl 28 asms (MPNs) are clonal haematological diseases characterized by excessive production of mature blood cells. Exome sequencing of patient samples have showed a relatively low degree genomic complexity for these diseases1. The majority of MPN patients carry somatic mutations in the JAK2 gene, with the JAK2V617F missense mutation being the most common in poly33 cythemia vera (PV, 95%) and essential thrombocythemia (ET, 60%) 2.

Description
Keywords
Biomarkers, Tumor, Gene Expression Regulation, Neoplastic, Humans, Janus Kinase 2, Leukemia, Erythroblastic, Acute, MicroRNAs, Mutation, STAT5 Transcription Factor, Signal Transduction, Tumor Cells, Cultured, Tumor Suppressor Proteins
Journal Title
Leukemia
Conference Name
Journal ISSN
0887-6924
1476-5551
Volume Title
32
Publisher
Springer Science and Business Media LLC
Sponsorship
Medical Research Council (MC_PC_12009)
Wellcome Trust (100140/Z/12/Z)
Wellcome Trust (097922/Z/11/B)
Leukaemia & Lymphoma Research (13003)
FP was supported by Fondazione Umberto Veronesi, and Institute Pasteur - Fondazione Cenci Bolognetti.