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PI3K inhibitors in inflammation, autoimmunity and cancer.

Published version
Peer-reviewed

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Authors

Stark, Anne-Katrien 
Sriskantharajah, Srividya 
Hessel, Edith M 

Abstract

The healthy immune system protects against infection and malignant transformation without causing significant damage to host tissues. Immune dysregulation results in diverse pathologies including autoimmune disease, chronic inflammatory disorders, allergies as well as immune deficiencies and cancer. Phosphoinositide 3-kinase (PI3K) signalling has been shown to be a key pathway in the regulation of the immune response and continues to be the focus of intense research. In recent years we have gained detailed understanding of PI3K signalling, and saw the development of potent and highly selective small molecule inhibitors, of which several are currently in clinical trials for the treatment of immune-related disorders and cancer. The role of PI3K signalling in the immune response has been the subject of detailed reviews; here we focus on relevant recent progress in pre-clinical and clinical development of PI3K inhibitors.

Description

Keywords

Animals, Autoimmune Diseases, Autoimmunity, Clinical Trials as Topic, Enzyme Inhibitors, Humans, Inflammation, Neoplasms, Phosphatidylinositol 3-Kinases, Phosphoinositide-3 Kinase Inhibitors

Journal Title

Curr Opin Pharmacol

Conference Name

Journal ISSN

1471-4892
1471-4973

Volume Title

23

Publisher

Elsevier BV