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Cell cycle-dependent phosphorylation and regulation of cellular differentiation.

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cam.issuedOnline2018-09-20
dc.contributor.authorHardwick, Laura JA
dc.contributor.authorAzzarelli, Roberta
dc.contributor.authorPhilpott, Anna
dc.contributor.orcidPhilpott, Anna [0000-0003-3789-2463]
dc.date.accessioned2018-10-03T04:44:22Z
dc.date.available2018-10-03T04:44:22Z
dc.date.issued2018-10-19
dc.description.abstractEmbryogenesis requires an exquisite regulation of cell proliferation, cell cycle withdrawal and differentiation into a massively diverse range of cells at the correct time and place. Stem cells also remain to varying extents in different adult tissues, acting in tissue homeostasis and repair. Therefore, regulated proliferation and subsequent differentiation of stem and progenitor cells remains pivotal throughout life. Recent advances have characterised the cell cycle dynamics, epigenetics, transcriptome and proteome accompanying the transition from proliferation to differentiation, revealing multiple bidirectional interactions between the cell cycle machinery and factors driving differentiation. Here, we focus on a direct mechanistic link involving phosphorylation of differentiation-associated transcription factors by cell cycle-associated Cyclin-dependent kinases. We discuss examples from the three embryonic germ layers to illustrate this regulatory mechanism that co-ordinates the balance between cell proliferation and differentiation.
dc.description.sponsorshipThis work was funded by MRC Research Grants (MR/K018329/1 (AP/RA), MR/L021129/1 (AP)Neuroblastoma UK (AP) and the Rosetrees and Stoneygate Trusts (AP/RA). LH is supported by a Peterhouse Research Fellowship
dc.format.mediumPrint-Electronic
dc.identifier.doi10.17863/CAM.30419
dc.identifier.eissn1470-8752
dc.identifier.issn0300-5127
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/283056
dc.languageeng
dc.language.isoeng
dc.publisherPortland Press Ltd.
dc.publisher.urlhttp://dx.doi.org/10.1042/bst20180276
dc.subjectcell cycle
dc.subjectcell differentiation
dc.subjectphosphorylation/dephosphorylation
dc.subjecttranscription factors
dc.subjectAnimals
dc.subjectCell Cycle
dc.subjectCell Differentiation
dc.subjectCell Lineage
dc.subjectCell Proliferation
dc.subjectChromatin
dc.subjectCyclin-Dependent Kinases
dc.subjectEctoderm
dc.subjectEmbryonic Development
dc.subjectEpigenesis, Genetic
dc.subjectHomeostasis
dc.subjectHumans
dc.subjectMesoderm
dc.subjectPhosphorylation
dc.subjectProteome
dc.subjectStem Cells
dc.subjectTranscription Factors
dc.subjectTranscriptome
dc.titleCell cycle-dependent phosphorylation and regulation of cellular differentiation.
dc.typeArticle
dcterms.dateAccepted2018-08-03
prism.endingPage1091
prism.issueIdentifier5
prism.publicationDate2018
prism.publicationNameBiochem Soc Trans
prism.startingPage1083
prism.volume46
pubs.funder-project-idMedical Research Council (MC_PC_12009)
pubs.funder-project-idMedical Research Council (MR/K018329/1)
pubs.funder-project-idMedical Research Council (MR/L021129/1)
rioxxterms.licenseref.startdate2018-10
rioxxterms.licenseref.urihttp://www.rioxx.net/licenses/all-rights-reserved
rioxxterms.typeJournal Article/Review
rioxxterms.versionAM
rioxxterms.versionofrecord10.1042/BST20180276

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