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Fibrinogen does not relate to cardiovascular or muscle manifestations in COPD: cross-sectional data from the ERICA study.

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cam.issuedOnline2018-04-04
dc.contributor.authorMohan, Divya
dc.contributor.authorForman, Julia R
dc.contributor.authorAllinder, Matthew
dc.contributor.authorMcEniery, Carmel M
dc.contributor.authorBolton, Charlotte Emma
dc.contributor.authorCockcroft, John R
dc.contributor.authorMacNee, William
dc.contributor.authorFuld, Jonathan
dc.contributor.authorMarchong, Mellone
dc.contributor.authorGale, Nichola Sian
dc.contributor.authorFisk, Marie
dc.contributor.authorNagarajan, Sridevi
dc.contributor.authorCheriyan, Joseph
dc.contributor.authorLomas, David A
dc.contributor.authorCalverley, Peter MA
dc.contributor.authorMiller, Bruce E
dc.contributor.authorTal-Singer, Ruth
dc.contributor.authorWilkinson, Ian B
dc.contributor.authorPolkey, Michael I
dc.contributor.authorERICA Consortium
dc.contributor.orcidMcEniery, Carmel [0000-0003-3636-0705]
dc.contributor.orcidFuld, Jonathan [0000-0003-1847-184X]
dc.contributor.orcidFisk, Marie [0000-0002-1292-7642]
dc.contributor.orcidCheriyan, Joseph [0000-0001-6921-1592]
dc.contributor.orcidWilkinson, Ian [0000-0001-6598-9399]
dc.date.accessioned2018-09-11T17:31:27Z
dc.date.available2018-09-11T17:31:27Z
dc.date.issued2018-12
dc.description.abstractCardiovascular and skeletal muscle manifestations constitute important comorbidities in COPD, with systemic inflammation proposed as a common mechanistic link. Fibrinogen has prognostic role in COPD. We aimed to determine whether aortic stiffness and quadriceps weakness are linked in COPD, and whether they are associated with the systemic inflammatory mediator-fibrinogen. Aortic pulse wave velocity (aPWV), quadriceps maximal volitional contraction (QMVC) force and fibrinogen were measured in 729 patients with stable, Global Initiative for Chronic Obstructive Lung Disease (GOLD) stages II-IV COPD. The cardiovascular and muscular manifestations exist independently (P=0.22, χ2). Fibrinogen was not associated with aPWV or QMVC (P=0.628 and P=0.621, respectively), making inflammation, as measured by plasma fibrinogen, an unlikely common aetiological factor.
dc.format.mediumPrint-Electronic
dc.identifier.doi10.17863/CAM.27544
dc.identifier.eissn1468-3296
dc.identifier.issn0040-6376
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/280176
dc.languageeng
dc.language.isoeng
dc.publisherBMJ
dc.publisher.urlhttp://dx.doi.org/10.1136/thoraxjnl-2018-211556
dc.subjectcopd pathology
dc.subjectAged
dc.subjectAorta
dc.subjectCross-Sectional Studies
dc.subjectFemale
dc.subjectFibrinogen
dc.subjectHumans
dc.subjectMale
dc.subjectMiddle Aged
dc.subjectMuscle Contraction
dc.subjectMuscle Weakness
dc.subjectProspective Studies
dc.subjectPulmonary Disease, Chronic Obstructive
dc.subjectPulse Wave Analysis
dc.subjectQuadriceps Muscle
dc.subjectVascular Stiffness
dc.titleFibrinogen does not relate to cardiovascular or muscle manifestations in COPD: cross-sectional data from the ERICA study.
dc.typeArticle
dcterms.dateAccepted2018-03-12
prism.endingPage1185
prism.issueIdentifier12
prism.publicationDate2018
prism.publicationNameThorax
prism.startingPage1182
prism.volume73
pubs.funder-project-idNIHR West Anglia Comprehensive Local Research Network (CLRN) (via Cambridge University Hospitals NHS Foundation Trust (CUH)) (RCF FUNDING 2013/14)
pubs.funder-project-idTechnology Strategy Board (101024 TP 9157-61188)
pubs.funder-project-idBritish Heart Foundation (None)
pubs.funder-project-idBritish Heart Foundation (None)
pubs.funder-project-idBritish Heart Foundation (None)
rioxxterms.licenseref.startdate2018-12
rioxxterms.licenseref.urihttp://www.rioxx.net/licenses/all-rights-reserved
rioxxterms.typeJournal Article/Review
rioxxterms.versionAM
rioxxterms.versionofrecord10.1136/thoraxjnl-2018-211556

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