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Maternal Blood Pressure Rise During Pregnancy and Offspring Obesity Risk at 4 to 7 Years Old: The Jiaxing Birth Cohort.

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cam.issuedOnline2017-09-27
cam.orpheus.successThu Jan 30 12:59:17 GMT 2020 - The item has an open VoR version.
dc.contributor.authorZheng, Ju-Sheng
dc.contributor.authorLiu, Huijuan
dc.contributor.authorOng, Ken K
dc.contributor.authorHuang, Tao
dc.contributor.authorGuan, Yuhong
dc.contributor.authorHuang, Yuan
dc.contributor.authorYang, Bo
dc.contributor.authorWang, Fenglei
dc.contributor.authorLi, Duo
dc.contributor.orcidZheng, Jusheng [0000-0001-6560-4890]
dc.contributor.orcidOng, Kenneth [0000-0003-4689-7530]
dc.date.accessioned2018-02-07T15:43:19Z
dc.date.available2018-02-07T15:43:19Z
dc.date.issued2017-11-01
dc.description.abstractCONTEXT: Maternal hypertensive disorders during pregnancy are suggested to affect obesity risk in offspring. However, little is known about the prospective association of rise in maternal blood pressure within normal range during pregnancy with this risk for obesity. OBJECTIVE: To clarify the associations of diastolic and systolic blood pressure during pregnancy among normotensive women with the risk for obesity in offspring. DESIGN: Prospective cohort study. SETTING: Southeast China. PARTICIPANTS: Up to 2013, a total of 88,406 mother-child pairs with anthropometric measurements of offspring age 4 to 7 years were included in the present analysis. MAIN OUTCOME MEASURES: Overweight/obesity risk in offspring. RESULTS: Among normotensive women, second- and third-trimester diastolic and systolic blood pressures were positively associated with risk for overweight/obesity in offspring: odds ratios per 10-mm Hg higher second- and third-trimester diastolic blood pressure were 1.05 [95% confidence interval (CI), 1.01 to 1.09] and 1.05 (95% CI, 1.02 to 1.10), respectively, and for systolic blood pressure were 1.08 (95% CI, 1.05 to 1.11) and 1.06 (95% CI, 1.03 to 1.09). Each 10-mm Hg greater rise in blood pressure between first and third trimesters was associated with a higher risk for offspring overweight/obesity: diastolic, 1.06 (95% CI, 1.01 to 1.10); systolic, 1.05 (95% CI, 1.02 to 1.07). Among all women (combining normotensive and hypertensive women), maternal hypertension in the second and third trimesters was associated with 49% and 14% higher risks for overweight/obesity in offspring, respectively. CONCLUSIONS: These results suggest that rise in maternal blood pressure during pregnancy and hypertension during pregnancy, independent of maternal body size before pregnancy, are risk factors for offspring childhood obesity.
dc.format.mediumPrint
dc.identifier.doi10.17863/CAM.18787
dc.identifier.eissn1945-7197
dc.identifier.issn0021-972X
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/271792
dc.languageeng
dc.language.isoeng
dc.publisherThe Endocrine Society
dc.publisher.urlhttp://dx.doi.org/10.1210/jc.2017-01500
dc.rightsAttribution 4.0 International
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.subjectAdult
dc.subjectAge of Onset
dc.subjectBlood Pressure
dc.subjectChild
dc.subjectChild, Preschool
dc.subjectChina
dc.subjectCohort Studies
dc.subjectFemale
dc.subjectHumans
dc.subjectHypertension, Pregnancy-Induced
dc.subjectInfant, Newborn
dc.subjectPediatric Obesity
dc.subjectPregnancy
dc.subjectPrenatal Exposure Delayed Effects
dc.subjectRisk Factors
dc.subjectYoung Adult
dc.titleMaternal Blood Pressure Rise During Pregnancy and Offspring Obesity Risk at 4 to 7 Years Old: The Jiaxing Birth Cohort.
dc.typeArticle
dcterms.dateAccepted2017-09-08
prism.endingPage4322
prism.issueIdentifier11
prism.publicationDate2017
prism.publicationNameJ Clin Endocrinol Metab
prism.startingPage4315
prism.volume102
pubs.funder-project-idEngineering and Physical Sciences Research Council (EP/N014588/1)
pubs.funder-project-idMedical Research Council (MC_UU_12015/2)
pubs.funder-project-idMRC (unknown)
pubs.funder-project-idMedical Research Council (MC_UU_12015/5)
pubs.funder-project-idEuropean Commission Horizon 2020 (H2020) Marie Sk?odowska-Curie actions (701708)
rioxxterms.licenseref.startdate2017-11
rioxxterms.licenseref.urihttp://www.rioxx.net/licenses/all-rights-reserved
rioxxterms.typeJournal Article/Review
rioxxterms.versionVoR
rioxxterms.versionofrecord10.1210/jc.2017-01500

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