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Plasma adiponectin levels and type 2 diabetes risk: a nested case-control study in a Chinese population and an updated meta-analysis.

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cam.issuedOnline2018-01-10
dc.contributor.authorWang, Yeli
dc.contributor.authorMeng, Rui-Wei
dc.contributor.authorKunutsor, Setor K
dc.contributor.authorChowdhury, Rajiv
dc.contributor.authorYuan, Jian-Min
dc.contributor.authorKoh, Woon-Puay
dc.contributor.authorPan, An
dc.contributor.orcidChowdhury, Rajiv [0000-0003-4881-5690]
dc.date.accessioned2018-06-04T11:48:44Z
dc.date.available2018-06-04T11:48:44Z
dc.date.issued2018-01-10
dc.description.abstractResults from previous prospective studies assessing the relation between adiponectin and type 2 diabetes (T2D) were not entirely consistent, and evidence in Chinese population is scarce. Moreover, the last meta-analysis did not examine the impact of metabolic variables on the adiponectin-T2D association. Therefore, we prospectively evaluated the adiponectin-T2D association among 571 T2D cases and 571 age-sex-matched controls nested within the Singapore Chinese Health Study (SCHS). Furthermore, we conducted an updated meta-analysis by searching prospective studies on Pubmed till September 2016. In the SCHS, the odds ratio of T2D, comparing the highest versus lowest tertile of adiponectin levels, was 0.30 (95% confidence interval: 0.17, 0.55) in the fully-adjusted model. The relation was stronger among heavier participants (body mass index ≥23 kg/m2) compared to their leaner counterparts (P for interaction = 0.041). In a meta-analysis of 34 prospective studies, the pooled relative risk was 0.53 (95% confidence interval: 0.47, 0.61) comparing the extreme tertiles of adiponectin with moderate heterogeneity (I 2 = 48.7%, P = 0.001). The adiponectin-T2D association remained unchanged after adjusting for inflammation and dyslipidemia markers, but substantially attenuated with adjustment for insulin sensitivity and/or glycaemia markers. Overall evidence indicates that higher adiponectin levels are associated with decreased T2D risk in Chinese and other populations.
dc.format.mediumElectronic
dc.identifier.doi10.17863/CAM.23821
dc.identifier.eissn2045-2322
dc.identifier.issn2045-2322
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/276523
dc.languageeng
dc.language.isoeng
dc.publisherSpringer Science and Business Media LLC
dc.publisher.urlhttp://dx.doi.org/10.1038/s41598-017-18709-9
dc.rightsAttribution 4.0 International
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.subjectAdiponectin
dc.subjectAged
dc.subjectBody Mass Index
dc.subjectCase-Control Studies
dc.subjectChina
dc.subjectDiabetes Mellitus, Type 2
dc.subjectFemale
dc.subjectHumans
dc.subjectMale
dc.subjectMiddle Aged
dc.subjectOdds Ratio
dc.subjectProspective Studies
dc.subjectRisk Factors
dc.titlePlasma adiponectin levels and type 2 diabetes risk: a nested case-control study in a Chinese population and an updated meta-analysis.
dc.typeArticle
dcterms.dateAccepted2017-12-15
prism.issueIdentifier1
prism.publicationDate2018
prism.publicationNameSci Rep
prism.startingPage406
prism.volume8
pubs.funder-project-idMedical Research Council (MR/L003120/1)
pubs.funder-project-idBritish Heart Foundation (None)
rioxxterms.licenseref.startdate2018-01-10
rioxxterms.licenseref.urihttp://www.rioxx.net/licenses/all-rights-reserved
rioxxterms.typeJournal Article/Review
rioxxterms.versionVoR
rioxxterms.versionofrecord10.1038/s41598-017-18709-9

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