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Targeting Mitochondrial Metabolism in Neuroinflammation: Towards a Therapy for Progressive Multiple Sclerosis.

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cam.issuedOnline2018-08-09
dc.contributor.authorPeruzzotti-Jametti, Luca
dc.contributor.authorPluchino, Stefano
dc.contributor.orcidPeruzzotti Jametti, Luca [0000-0002-9396-5607]
dc.contributor.orcidPluchino, Stefano [0000-0002-6267-9472]
dc.date.accessioned2018-11-23T00:32:47Z
dc.date.available2018-11-23T00:32:47Z
dc.date.issued2018-10
dc.description.abstractThe lack of effective treatment options for chronic neurological conditions, such as multiple sclerosis (MS), highlights the need to re-evaluate disease pathophysiology in the process of identifying novel therapeutic targets. The persistent activation of mononuclear phagocytes (MPs) is one of the major drivers of neurodegeneration and it sustains central nervous system (CNS) damage. Mitochondrial metabolism influences the activity of MPs, and the metabolites that they produce have key signalling roles in inflammation. However, how changes in immune cell metabolism sustain a chronic state of neuroinflammation is not fully understood. Novel molecular and cellular therapies for chronic neuroinflammation should be developed to target mitochondrial metabolism in innate immune cells to prevent secondary neurological damage and the accumulation of irreversible disability in patients.
dc.format.mediumPrint-Electronic
dc.identifier.doi10.17863/CAM.33176
dc.identifier.eissn1471-499X
dc.identifier.issn1471-4914
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/285832
dc.languageeng
dc.language.isoeng
dc.publisherElsevier BV
dc.publisher.urlhttp://dx.doi.org/10.1016/j.molmed.2018.07.007
dc.subjectimmune metabolism
dc.subjectmacrophages
dc.subjectmicroglia
dc.subjectmitochondria
dc.subjectneuroinflammation
dc.subjectprogressive multiple sclerosis
dc.subjectCentral Nervous System
dc.subjectCrotonates
dc.subjectDimethyl Fumarate
dc.subjectElectron Transport
dc.subjectGlymphatic System
dc.subjectHumans
dc.subjectHydroxybutyrates
dc.subjectImmunity, Innate
dc.subjectMetabolic Networks and Pathways
dc.subjectMicroglia
dc.subjectMitochondria
dc.subjectMolecular Targeted Therapy
dc.subjectMononuclear Phagocyte System
dc.subjectMultiple Sclerosis, Chronic Progressive
dc.subjectNeurodegenerative Diseases
dc.subjectNitriles
dc.subjectSignal Transduction
dc.subjectStem Cell Transplantation
dc.subjectToluidines
dc.titleTargeting Mitochondrial Metabolism in Neuroinflammation: Towards a Therapy for Progressive Multiple Sclerosis.
dc.typeArticle
dcterms.dateAccepted2018-07-17
prism.endingPage855
prism.issueIdentifier10
prism.publicationDate2018
prism.publicationNameTrends Mol Med
prism.startingPage838
prism.volume24
pubs.funder-project-idEuropean Research Council (260511)
rioxxterms.licenseref.startdate2018-10
rioxxterms.licenseref.urihttp://www.rioxx.net/licenses/all-rights-reserved
rioxxterms.typeJournal Article/Review
rioxxterms.versionAM
rioxxterms.versionofrecord10.1016/j.molmed.2018.07.007

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