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  • Impact of Alternative Splicing on the Human Proteome 

    Liu, Y; Gonzàlez-Porta, M; Santos, S; Brazma, A; Marioni, JC; Aebersold, R; Venkitaraman, Ashok Ramakrishnan et al. (Elsevier, 2017-08-01)
    Alternative splicing is a critical determinant of genome complexity and, by implication, is assumed to engender proteomic diversity. This notion has not been experimentally tested in a targeted, quantitative manner. Here, ...
  • Modulating Protein-Protein Interactions of the Mitotic Polo-like Kinases to Target Mutant KRAS 

    Narvaez, AJ; Ber, S; Crooks, A; Emery, A; Hardwick, B; Guarino Almeida, E; Huggins, DJ et al. (Elsevier, 2017-08-10)
    Mutations activating KRAS underlie many forms of cancer, but are refractory to therapeutic targeting. Here, we develop Poloppin, an inhibitor of protein-protein interactions via the Polo-box domain (PBD) of the mitotic ...
  • Lung tumors with distinct p53 mutations respond similarly to p53 targeted therapy but exhibit genotype-specific statin sensitivity 

    Turrell, FK; Kerr, EM; Gao, M; Thorpe, H; Doherty, Gary Joseph; Cridge, J; Shorthouse, D et al. (Cold Spring Harbor Laboratory Press, 2017-08-08)
    Lung adenocarcinoma accounts for ∼40% of lung cancers, the leading cause of cancer-related death worldwide, and current therapies provide only limited survival benefit. Approximately half of lung adenocarcinomas harbor ...
  • Development of a Prognostic Model That Predicts Survival After Pancreaticoduodenectomy for Ampullary Cancer. 

    Feretis, Michail; Wang, T; Iype, S; Duckworth, A; Brais, R; Basu, Bristi; Jamieson, N et al. (Wolters Kluwer Health, 2017-07-31)
    Objectives: The aims of this study were to i) identify independent predictors of survival following pancreaticoduodenectomy for ampullary cancer and ii) develop a prognostic model of survival. Methods: Data were analysed ...

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