Department of Oncology
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Characterising DNA methylation in tissue and liquid samples from patients with renal tumours
The incidence of renal cell carcinoma (RCC) and small renal masses (SRMs), defined as <4cm in diameter, is increasing dramatically. SRMs encompass a variety of potential diagnoses, including benign and malignant tumours, ... -
Cellular Senescence in Non-Small Cell Lung Cancer: from mechanisms to therapeutic opportunities
Lung cancer is the leading cause of cancer-related deaths in our society due to the inefficiency of early detection strategies and the high rate of treatment failure. Therefore, a better understanding of the mechanisms ... -
The evolutionary dynamics of clonal haematopoiesis and its progression to acute myeloid leukaemia
Acute myeloid leukaemia (AML) is an aggressive blood cancer which claims the lives of 70-80% of patients within 5 years of diagnosis. Like many other cancers, AML usually develops as a consequence of serial acquisition ... -
The Role of the Proneural Transcription Factor ASCL1 in Neuroblastoma Cell Division and Differentiation
Neuroblastoma is the most common solid childhood cancer and typically has a very poor prognosis. Neuroblastoma is a ‘cancer of improper development’ and is thought to arise from sympathetic neuroblast precursors that fail ...
