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  • BRCA2 Regulates Transcription Elongation by RNA Polymerase II to Prevent R-Loop Accumulation. 

    Shivji, MKK; Renaudin, Xavier Robert; Williams, CH; Venkitaraman, Ashok Ramakrishnan (Elsevier, 2018-01-23)
    The controlled release of RNA polymerase II (RNAPII) from promoter-proximal pausing (PPP) sites is critical for transcription elongation in metazoans. We show that the human tumor suppressor BRCA2 interacts with RNAPII to ...
  • Genetic Variants Related to Longer Telomere Length are Associated with Increased Risk of Renal Cell Carcinoma. 

    Machiela, Mitchell J; Hofmann, Jonathan N; Carreras-Torres, Robert; Brown, Kevin M; Johansson, Mattias; Wang, Zhaoming; Foll, Matthieu et al. (2017-11)
  • Mitochondria-Endoplasmic Reticulum Contact Sites Function as Immunometabolic Hubs that Orchestrate the Rapid Recall Response of Memory CD8+ T Cells. 

    Bantug, Glenn R; Fischer, Marco; Grählert, Jasmin; Balmer, Maria L; Unterstab, Gunhild; Develioglu, Leyla; Steiner, Rebekah et al. (2018-03-06)
  • Itaconate is an anti-inflammatory metabolite that activates Nrf2 via alkylation of KEAP1. 

    Mills, Evanna L; Ryan, Dylan G; Prag, Hiran A; Dikovskaya, Dina; Menon, Deepthi; Zaslona, Zbigniew; Jedrychowski, Mark P et al. (Springer Nature, 2018-04)
    The endogenous metabolite itaconate has recently emerged as a regulator of macrophage function but the precise mechanism of action remains poorly understood. We report that itaconate is required for the activation of the ...

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