Department of Oncology
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Elucidating oncogenic mechanisms in human B cell malignancies
(2018-11-24)This study consists of two pieces of work investigating haematological malignancies; Acute Lymphoblastic Leukaemia (ALL) and Diffuse Large B Cell Lymphoma (DLBCL). Firstly, Pre-B ALL represents the most common paediatric ... -
Development of computer-based algorithms for unsupervised assessment of radiotherapy contouring
(2019-02-23)INTRODUCTION: Despite the advances in radiotherapy treatment delivery, target volume delineation remains one of the greatest sources of error in the radiotherapy delivery process, which can lead to poor tumour control ... -
An observational study showed that explaining randomization using gambling-related metaphors and computer-agency descriptions impeded randomized clinical trial recruitment.
(2018-07)© 2018 University of Bristol Objectives: To explore how the concept of randomization is described by clinicians and understood by patients in randomized controlled trials (RCTs) and how it contributes to patient understanding ... -
Targeting Phosphopeptide Recognition by the Human BRCA1 Tandem BRCT Domain to Interrupt BRCA1-Dependent Signaling
(Elsevier, 2018-06)Intracellular signals triggered by DNA breakage flow through proteins containing BRCT (BRCA1 carboxyl-terminal) domains. This family, comprising 23 conserved phosphopeptide-binding modules in man, is inaccessible to ...
