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  BRCA2 Regulates Transcription Elongation by RNA Polymerase II to Prevent R-Loop Accumulation. 

  Shivji, MKK; Renaudin, Xavier Robert; Williams, CH; Venkitaraman, Ashok Ramakrishnan (Elsevier, 2018-01-23)

  The controlled release of RNA polymerase II (RNAPII) from promoter-proximal pausing (PPP) sites is critical for transcription elongation in metazoans. We show that the human tumor suppressor BRCA2 interacts with RNAPII to ...
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  Genetic Variants Related to Longer Telomere Length are Associated with Increased Risk of Renal Cell Carcinoma. 

  Machiela, Mitchell J; Hofmann, Jonathan N; Carreras-Torres, Robert; Brown, Kevin M; Johansson, Mattias; Wang, Zhaoming; Foll, MatthieuLi, PengRothman, NathanielSavage, Sharon AGaborieau, ValerieMcKay, James DYe, YuanqingHenrion, MarcBruinsma, FionaJordan, SusanSeveri, GianlucaHveem, KristianVatten, Lars JFletcher, TonyKoppova, KvetoslavaLarsson, Susanna CWolk, AlicjaBanks, Rosamonde ESelby, Peter JEaston, Douglas FrederickPharoah, Paul DavidAndreotti, GabriellaFreeman, Laura E BeaneKoutros, StellaAlbanes, DemetriusMannisto, SatuWeinstein, StephanieClark, Peter EEdwards, Todd ELipworth, LorenGapstur, Susan MStevens, Victoria LCarol, HallieFreedman, Matthew LPomerantz, Mark MCho, EunyoungKraft, PeterPreston, Mark AWilson, Kathryn MGaziano, J MichaelSesso, Howard SBlack, AmandaFreedman, Neal DHuang, Wen-YiAnema, John GKahnoski, Richard JLane, Brian RNoyes, Sabrina LPetillo, DavidColli, Leandro MSampson, Joshua NBesse, CelineBlanche, HeleneBoland, AnneBurdette, LaurieProkhortchouk, EgorSkryabin, Konstantin GYeager, MeredithMijuskovic, MirjanaOgnjanovic, MiodragForetova, LenkaHolcatova, IvanaJanout, VladimirMates, DanaMukeriya, AnushRascu, StefanZaridze, DavidBencko, VladimirCybulski, CezaryFabianova, EleonoraJinga, ViorelLissowska, JolantaLubinski, JanNavratilova, MarieRudnai, PeterSzeszenia-Dabrowska, NeonilaBenhamou, SimoneCancel-Tassin, GeraldineCussenot, OlivierBueno-de-Mesquita, H BasCanzian, FedericoDuell, Eric JLjungberg, BörjeSitaram, Raviprakash TPeters, UlrikeWhite, EmilyAnderson, Garnet LJohnson, LisaLuo, JuhuaBuring, JulieLee, I-MinChow, Wong-HoMoore, Lee EWood, ChristopherEisen, Timothy GeorgeLarkin, JamesChoueiri, Toni KLathrop, G MarkTeh, Bin TeanDeleuze, Jean-FrancoisWu, XifengHoulston, Richard SBrennan, PaulChanock, Stephen JScelo, GhislainePurdue, Mark P et al. (2017-11)
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  Mitochondria-Endoplasmic Reticulum Contact Sites Function as Immunometabolic Hubs that Orchestrate the Rapid Recall Response of Memory CD8+ T Cells. 

  Bantug, Glenn R; Fischer, Marco; Grählert, Jasmin; Balmer, Maria L; Unterstab, Gunhild; Develioglu, Leyla; Steiner, RebekahZhang, LianjunCosta, Ana SHGubser, Patrick MBurgener, Anne-ValérieSauder, UrsulaLöliger, JordanBelle, RékaDimeloe, SarahLötscher, JonasJauch, AnnaïseRecher, MikeHönger, GideonHall, Michael NRomero, PedroFrezza, ChristianHess, Christoph et al. (2018-03-06)
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  Itaconate is an anti-inflammatory metabolite that activates Nrf2 via alkylation of KEAP1. 

  Mills, Evanna L; Ryan, Dylan G; Prag, Hiran A; Dikovskaya, Dina; Menon, Deepthi; Zaslona, Zbigniew; Jedrychowski, Mark PCosta, Ana SHHiggins, MaureenHams, EmilySzpyt, JohnRuntsch, Marah CKing, MartinMcGouran, Joanna FFischer, RomanKessler, Benedikt MMcGettrick, Anne FHughes, Mark MCarroll, Richard GBooty, Lee MKnatko, Elena VMeakin, Paul JAshford, Michael LJModis, Louise KBrunori, GinoSévin, Daniel CFallon, Padraic GCaldwell, Stuart TKunji, Edmund RichardChouchani, Edward TFrezza, ChristianDinkova-Kostova, Albena THartley, Richard CMurphy, Michael PatrickO'Neill, Luke A et al. (Springer Nature, 2018-04)

  The endogenous metabolite itaconate has recently emerged as a regulator of macrophage function but the precise mechanism of action remains poorly understood. We report that itaconate is required for the activation of the ...

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