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  • An observational study showed that explaining randomization using gambling-related metaphors and computer-agency descriptions impeded randomized clinical trial recruitment. 

    Jepson, Marcus; Elliott, Daisy; Conefrey, Carmel; Wade, Julia; Rooshenas, Leila; Wilson, Caroline; Beard, David et al. (2018-07)
    © 2018 University of Bristol Objectives: To explore how the concept of randomization is described by clinicians and understood by patients in randomized controlled trials (RCTs) and how it contributes to patient understanding ...
  • Targeting Phosphopeptide Recognition by the Human BRCA1 Tandem BRCT Domain to Interrupt BRCA1-Dependent Signaling 

    Periasamy, Jayaprakash; Kurdekar, Vadiraj; Jasti, Subbarao; Nijaguna, Mamatha B; Boggaram, Sanjana; Hurakadli, Manjunath A; Raina, Dhruv et al. (Elsevier, 2018-06)
    Intracellular signals triggered by DNA breakage flow through proteins containing BRCT (BRCA1 carboxyl-terminal) domains. This family, comprising 23 conserved phosphopeptide-binding modules in man, is inaccessible to ...
  • A First-in-Human Study of the New Oral Selective Estrogen Receptor Degrader AZD9496 for ER+/HER2- Advanced Breast Cancer. 

    Hamilton, Erika P; Patel, Manish R; Armstrong, Anne C; Baird, Richard Douglas; Jhaveri, Komal; Hoch, Matthias; Klinowska, Teresa et al. (American Association for Cancer Research, 2018-02-13)
    Purpose: AZD9496 is an oral nonsteroidal, small-molecule inhibitor of estrogen receptor alpha (ERα) and a potent and selective antagonist and degrader of ERα. This first-in-human phase I study determined the safety and ...
  • The Landscape of Somatic Genetic Alterations in Breast Cancers From ATM Germline Mutation Carriers. 

    Weigelt, Britta; Bi, Rui; Kumar, Rahul; Blecua, Pedro; Mandelker, Diana L; Geyer, Felipe C; Pareja, Fresia et al. (OUP, 2018-02-28)
    Pathogenic germline variants in ataxia-telangiectasia mutated (ATM), a gene that plays a role in DNA damage response and cell cycle checkpoints, confer an increased breast cancer (BC) risk. Here, we investigated the ...

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