Theses - Oncology
About this collection
Recent Submissions
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Predicting Response to Neoadjuvant Chemotherapy in Breast Cancer with Gene Expression and Computational Pathology
Many breast cancer patients are treated with chemotherapy before surgery for the removal of the tumour, which is known as neoadjuvant chemotherapy (NAT). It improves outcome for many patients, and their response to the ... -
The role of NEDD9 in TGFβ mediated tumour initiating cell dynamics in the Claudin-low breast cancer subtype
Breast cancer is an extremely heterogeneous disease comprising at least ten different subtypes, each exhibiting different characteristics in progression, prognosis and response to treatment. Transforming growth factor β ... -
Defining Epithelial Cell Fate Dynamics of the Oesophagus during Postnatal Development and Homeostasis
Epithelial cells can respond rapidly to changing tissue demands to ensure organism survival. However, the mechanisms that finely control how cells adapt their behaviour remain largely unknown. To uncover the rules that ... -
Somatic evolution in normal human endometrium
(2020-03)For decades, the primary focus of cancer research has been the cancer tissue itself. Advances in next-generation sequencing technologies have enabled identification and characterisation of driver mutations, provided insights ...
