Theses - Oncology
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Pencil beam dose calculation for proton therapy on graphics processing units
(2016-02-02)Radiotherapy delivered using scanned beams of protons enables greater conformity between the dose distribution and the tumour than conventional radiotherapy using X rays. However, the dose distributions are more sensitive ... -
Incorporating range uncertainty into proton therapy treatment planning
(Physics in Medicine and Biology, British Journal of Radiology, 2015-06-09)This dissertation addresses the issue of robustness in proton therapy treatment planning for cancer treatment. Proton therapy is considered to be advantageous in treating most childhood cancers and certain adult cancers, ... -
Covalent modification and intrinsic disorder in the stability of the proneural protein Neurogenin 2
(2011-10-11)Neurogenin 2 (Ngn2) is a basic Helix-Loop-Helix (bHLH) transcription factor regulating differentiation and cell cycle exit in the developing brain. By transcriptional upregulation of a cascade of other bHLH factors, neural ... -
Characterising the function of CDK5RAP2 in the vertebrate centrosome
(2010-10-12)The centrosome is the major microtubule organising centre in vertebrate cells. CDK5RAP2 is a human protein that localises to the centrosome. At the start of this thesis work, the function of CDK5RAP2 was uncharacterised. ...
