Theses - Chemistry
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Recent Submissions
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The Development of Divinyl-Heteroaryl Linkers for the Synthesis of Stable and Functional Antibody-Drug Conjugates
(2020-02-22)Antibody-drug conjugates (ADCs) are a class of targeted therapeutics that utilise the exquisite selectivity of antibodies for membrane receptors to selectively deliver cytotoxic warheads to specific cell types, such as ... -
First and Second-Principles Atomistic Modelling of Ge-Sb-Te Phase-Change Memory Materials
(2019-11-30)Phase-change memory materials are semiconductors with a fast and re- versible transition between a resistive amorphous phase and a conductive crystalline phase. A sufficiently large contrast in electrical resistivity can be ... -
Inhibition of enzymes from mycobacteria using fragment-based approaches
The work described in this thesis is focused on the application of fragment-based approaches for two essential mycobacterial target proteins, fumarate hydratase (fumarase) from Mycobacterium tuberculosis (Mtb) and tRNA ... -
Analysing Vibrational Circular Dichroism: Confidence Levels for Absolute Chirality Assignment
(2019-10-26)The application of chiroptical methods such as vibrational circular dichroism (VCD) spectroscopy is valuable in the assignment of absolute chirality. Assignment of chirality traditionally involves visual comparison of ...
