Theses - Chemistry
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Recent Submissions
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Applications of Hypervalent Iodine Reagents: From Enantioselective Copper-Catalysed Arylation-Semipinacol Cascade to Methionine Functionalisation for Peptide Macrocyclisation
(2018-11-30)The unifying theme of this thesis is the exploitation of the reactivity of aryliodonium salts as electrophile transfer reagents. In the first part of the thesis, diaryliodonium salts are employed as arylation reagents for ... -
Next-generation fluorophores for single-molecule and super-resolution fluorescence microscopy
(2018-11-24)The development of single-molecule and super-resolution fluorescence techniques has revolutionised biological imaging. Nano-scale cellular structures and heterogeneous dynamic processes are now able to be visualised ... -
Functional Relevance of Protein Disorder: Why is Disorder Favourable?
(2018-09-24)For half a century, the central tenet of protein science has been grounded on the idea that the three-dimensional structure of a protein underlies its function. However, increasing evidence of natively unstructured but ... -
Improved In Silico Methods for Target Deconvolution in Phenotypic Screens
(2018-09-30)Target-based screening projects for bioactive (orphan) compounds have been shown in many cases to be insufficiently predictive for in vivo efficacy, leading to attrition in clinical trials. Phenotypic screening has hence ...
