An internationally competitive research programme; themes include cell signalling and control of gene expression, to molecular microbiology, plant molecular biology and biofuel research, cancer and cardiovascular biology

The Department of Biochemistry is a member of the School of Biological Sciences and is one of the largest departments in Cambridge - around 400 research and support staff - with an internationally competitive research programme. The Department’s research contributes to the themes that describe the research in the School. We have attracted many outstanding independent research fellows with funding from the Wellcome Trust, British Heart Foundation, BBSRC and MRC, and several of our senior staff have been seconded to prestigious fellowships. The Department houses facilities funded by Wellcome Trust, BBSRC and MRC for modern biomolecular research, including an 800MHz NMR facility, modern X-ray laboratories, core facilities for mass spectrometry and plasmon resonance, advanced services for protein and nucleic acid sequencing. We have collaborated with the Department of Genetics in establishing the Systems Biology Centre, adjacent to the Sanger Building, which houses array technologies, proteomics and informatics, and we have established metabolomics elsewhere in the Department. We also participate in the new Wellcome Trust Centre for Stem Cell Research. These new developments underpin research in a range of different biological processes from molecular enzymology, through cell signalling and control of gene expression, to molecular microbiology, plant molecular biology and biofuel research, cancer and cardiovascular biology.

### Recent Submissions

• #### DNA-PKcs structure suggests an allosteric mechanism modulating DNA double-strand break repair ﻿

(American Association for the Advancement of Science, 2017-02-03)
DNA-dependent protein kinase catalytic subunit (DNA-PKcs) is a central component of nonhomologous end joining (NHEJ), repairing DNA double-strand breaks that would otherwise lead to apoptosis or cancer. We have solved its ...

• #### Genomes, Structural Biology, and Drug Discovery: Combating the Impacts of Mutations in Genetic Disease and Antibiotic Resistance ﻿

For over four decades structural biology has used to understand the mechanisms of disease and structure-guided approaches have demonstrated clearly that they can contribute to many aspects of early drug discovery, both ...
• #### Genome Sequence of $\textit{Serratia marcescens}$ MSU97, a Plant-Associated Bacterium That Makes Multiple Antibiotics ﻿

(American Society for Microbiology, 2017-03-02)
$\textit{Serratia marcescens}$ MSU97 was isolated from the Guayana region of Venezuela due to its ability to suppress plant-pathogenic oomycetes. Here, we report the genome sequence of MSU97, which produces various ...