Department of Biochemistry
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An internationally competitive research programme; themes include cell signalling and control of gene expression, to molecular microbiology, plant molecular biology and biofuel research, cancer and cardiovascular biology
The Department of Biochemistry is a member of the School of Biological Sciences and is one of the largest departments in Cambridge - around 400 research and support staff - with an internationally competitive research programme. The Department’s research contributes to the themes that describe the research in the School. We have attracted many outstanding independent research fellows with funding from the Wellcome Trust, British Heart Foundation, BBSRC and MRC, and several of our senior staff have been seconded to prestigious fellowships. The Department houses facilities funded by Wellcome Trust, BBSRC and MRC for modern biomolecular research, including an 800MHz NMR facility, modern X-ray laboratories, core facilities for mass spectrometry and plasmon resonance, advanced services for protein and nucleic acid sequencing. We have collaborated with the Department of Genetics in establishing the Systems Biology Centre, adjacent to the Sanger Building, which houses array technologies, proteomics and informatics, and we have established metabolomics elsewhere in the Department. We also participate in the new Wellcome Trust Centre for Stem Cell Research. These new developments underpin research in a range of different biological processes from molecular enzymology, through cell signalling and control of gene expression, to molecular microbiology, plant molecular biology and biofuel research, cancer and cardiovascular biology.
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Structural and Biochemical Characterisation of the HR1 domains of the Protein Kinase C-related kinase family (2019-05-18)The Rho family of small GTPases act as molecular switches in the cell and are involved in signalling pathways implicated in cytoskeletal organisation. To mediate their effects, they interact with downstream effectors. The ...
(2019-07-20)Abortive infection (Abi) is an anti-phage mechanism in which a bacterium initiates its own death upon phage infection. This prevents or decreases the production of phage progeny and protects clonal siblings in the bacterial ...
New Pleiotropic Co-Regulators of Gas Vesicle and Secondary Metabolite Production in Serratia sp. ATCC39006 (2019-05-18)Serratia sp. ATCC39006 (S39006) is a rod-shaped, motile, Gram-negative phytopathogenic bacterium. It is the only enterobacterium known to make gas vesicles (GVs) naturally. GVs are proteinaceous, intracellular organelles ...
Three enzymes - One substrate Regulation of carbon flux through a "non-canonical" metabolic branchpoint (2019-06-01)Pseudomonas aeruginosa is a common opportunistic pathogen. Recent work indicates that in many infection scenarios, P. aeruginosa exhibits an exquisite predilection for metabolizing fatty acids to yield acetyl-CoA. In most ...