Department of Biochemistry
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An internationally competitive research programme; themes include cell signalling and control of gene expression, to molecular microbiology, plant molecular biology and biofuel research, cancer and cardiovascular biology
The Department of Biochemistry is a member of the School of Biological Sciences and is one of the largest departments in Cambridge - around 400 research and support staff - with an internationally competitive research programme. The Department’s research contributes to the themes that describe the research in the School. We have attracted many outstanding independent research fellows with funding from the Wellcome Trust, British Heart Foundation, BBSRC and MRC, and several of our senior staff have been seconded to prestigious fellowships. The Department houses facilities funded by Wellcome Trust, BBSRC and MRC for modern biomolecular research, including an 800MHz NMR facility, modern X-ray laboratories, core facilities for mass spectrometry and plasmon resonance, advanced services for protein and nucleic acid sequencing. We have collaborated with the Department of Genetics in establishing the Systems Biology Centre, adjacent to the Sanger Building, which houses array technologies, proteomics and informatics, and we have established metabolomics elsewhere in the Department. We also participate in the new Wellcome Trust Centre for Stem Cell Research. These new developments underpin research in a range of different biological processes from molecular enzymology, through cell signalling and control of gene expression, to molecular microbiology, plant molecular biology and biofuel research, cancer and cardiovascular biology.
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Recent Submissions
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Structural and Mechanistic Studies of Multidrug Resistance Efflux Pumps in Multiple Families
(2021-09-16)Multidrug resistance, whereby pathogens develop resistance to several antimicrobial agents, is a large and growing public health concern globally. In order to combat its continued spread, a better understanding of resistance ... -
Role of Neuraminidase-mediated Desialylation in Microglial Activation
Microglia are the innate immune cells of the central nervous system (CNS) and play key roles in mediating the removal of dead or dying neurons, neurotoxic aggregates or neuronal debris, thus contributing to CNS health. ... -
Regulation of Mitochondrial Function by Histone Acetylation and Mitochondrial Acetyl-CoA Levels in Saccharomyces cerevisiae
Previous studies from our lab demonstrated that starvation signals transmitted by multiple kinases, including the PAS kinase Rim15, the DYRK kinase Yak1, the GSK-3 homologue Mck1 and the energy-sensing SNF1 complex, were ... -
Investigating the C-terminal region of RalA: regulation through membrane dynamics and protein-protein interactions
(2021-10-01)RalA and RalB, members of the Ras superfamily, play a pivotal role in tumour progression in Ras-driven cancers, hence there is a growing need to understand these proteins in terms of their structure and function to facilitate ...
