Department of Biochemistry
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An internationally competitive research programme; themes include cell signalling and control of gene expression, to molecular microbiology, plant molecular biology and biofuel research, cancer and cardiovascular biology
The Department of Biochemistry is a member of the School of Biological Sciences and is one of the largest departments in Cambridge - around 400 research and support staff - with an internationally competitive research programme. The Department’s research contributes to the themes that describe the research in the School. We have attracted many outstanding independent research fellows with funding from the Wellcome Trust, British Heart Foundation, BBSRC and MRC, and several of our senior staff have been seconded to prestigious fellowships. The Department houses facilities funded by Wellcome Trust, BBSRC and MRC for modern biomolecular research, including an 800MHz NMR facility, modern X-ray laboratories, core facilities for mass spectrometry and plasmon resonance, advanced services for protein and nucleic acid sequencing. We have collaborated with the Department of Genetics in establishing the Systems Biology Centre, adjacent to the Sanger Building, which houses array technologies, proteomics and informatics, and we have established metabolomics elsewhere in the Department. We also participate in the new Wellcome Trust Centre for Stem Cell Research. These new developments underpin research in a range of different biological processes from molecular enzymology, through cell signalling and control of gene expression, to molecular microbiology, plant molecular biology and biofuel research, cancer and cardiovascular biology.
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Calculation of 3D genome structures for comparison of chromosome conformation capture experiments with microscopy: An evaluation of single-cell Hi-C protocols. (Taylor & Francis, 2018-01)Single-cell chromosome conformation capture approaches are revealing the extent of cell-to-cell variability in the organization and packaging of genomes. These single-cell methods, unlike their multi-cell counterparts, ...
(2018-04-03)Some photosynthetically active bacteria transfer electrons across their membranes, generating electrical photocurrents in biofilms. Devices harvesting solar energy by this mechanism are currently limited by the charge ...
Parallel genome-wide screens identify synthetic viable interactions between the BLM helicase complex and Fanconi anemia. (Springer Nature, 2017-11)Maintenance of genome integrity via repair of DNA damage is a key biological process required to suppress diseases, including Fanconi anemia (FA). We generated loss-of-function human haploid cells for FA complementation ...
Multispecies reconstructions uncover widespread conservation, and lineage-specific elaborations in eukaryotic mRNA metabolism. (Public Library of Science (PLoS), 2018-01)The degree of conservation and evolution of cytoplasmic mRNA metabolism pathways across the eukaryotes remains incompletely resolved. In this study, we describe a comprehensive genome and transcriptome-wide analysis of ...