Department of Biochemistry
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An internationally competitive research programme; themes include cell signalling and control of gene expression, to molecular microbiology, plant molecular biology and biofuel research, cancer and cardiovascular biology
The Department of Biochemistry is a member of the School of Biological Sciences and is one of the largest departments in Cambridge - around 400 research and support staff - with an internationally competitive research programme. The Department’s research contributes to the themes that describe the research in the School. We have attracted many outstanding independent research fellows with funding from the Wellcome Trust, British Heart Foundation, BBSRC and MRC, and several of our senior staff have been seconded to prestigious fellowships. The Department houses facilities funded by Wellcome Trust, BBSRC and MRC for modern biomolecular research, including an 800MHz NMR facility, modern X-ray laboratories, core facilities for mass spectrometry and plasmon resonance, advanced services for protein and nucleic acid sequencing. We have collaborated with the Department of Genetics in establishing the Systems Biology Centre, adjacent to the Sanger Building, which houses array technologies, proteomics and informatics, and we have established metabolomics elsewhere in the Department. We also participate in the new Wellcome Trust Centre for Stem Cell Research. These new developments underpin research in a range of different biological processes from molecular enzymology, through cell signalling and control of gene expression, to molecular microbiology, plant molecular biology and biofuel research, cancer and cardiovascular biology.
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Recent Submissions
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Nucleosome-independent permanently condensed chromosome: investigation of novel nuclear organisation in the dinoflagellates
(2019-11-08)Dinoflagellates hold vast diversities and are major contributors to overall marine primary production. Close relatives to the apicomplexan parasites and ciliates, the dinoflagellates, however, have a shockingly different ... -
Enzymatic Ring Formation in Polyether Tetronate Antibiotic Biosynthesis
(2020-05-16)The formation of rings in carbon backbones is essential for the biological activity of many natural products. The polyether tetronate antibiotics tetronasin, tetronomycin, and tetromadurin (SF2487/A80577) are notable for ... -
The glyoxylate shunt as a target for antibacterial intervention in Pseudomonas aeruginosa
(2019-11-30)Pseudomonas aeruginosa is an opportunistic human pathogen responsible for a large proportion of drug-resistant, hospital-acquired infections worldwide. These infections are notoriously difficult to treat due to P. aeruginosa’s ... -
Two isoforms of pyruvate kinase enzymes in Pseudomonas aeruginosa with distinct functional and structural properties
(2019-11-30)In most organisms, phosphofructokinase (PFK) and pyruvate kinase (PK) are the key glycolytic regulatory enzymes. However, the opportunistic human pathogen, Pseudomonas aeruginosa, relies entirely on the Entner-Doudoroff ...
