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An internationally competitive research programme; themes include cell signalling and control of gene expression, to molecular microbiology, plant molecular biology and biofuel research, cancer and cardiovascular biology

The Department of Biochemistry is a member of the School of Biological Sciences and is one of the largest departments in Cambridge - around 400 research and support staff - with an internationally competitive research programme. The Department’s research contributes to the themes that describe the research in the School. We have attracted many outstanding independent research fellows with funding from the Wellcome Trust, British Heart Foundation, BBSRC and MRC, and several of our senior staff have been seconded to prestigious fellowships. The Department houses facilities funded by Wellcome Trust, BBSRC and MRC for modern biomolecular research, including an 800MHz NMR facility, modern X-ray laboratories, core facilities for mass spectrometry and plasmon resonance, advanced services for protein and nucleic acid sequencing. We have collaborated with the Department of Genetics in establishing the Systems Biology Centre, adjacent to the Sanger Building, which houses array technologies, proteomics and informatics, and we have established metabolomics elsewhere in the Department. We also participate in the new Wellcome Trust Centre for Stem Cell Research. These new developments underpin research in a range of different biological processes from molecular enzymology, through cell signalling and control of gene expression, to molecular microbiology, plant molecular biology and biofuel research, cancer and cardiovascular biology.

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Recent Submissions

  • A multilaboratory comparison of calibration accuracy and the performance of external references in analytical ultracentrifugation. 

    Zhao, Huaying; Ghirlando, Rodolfo; Alfonso, Carlos; Arisaka, Fumio; Attali, Ilan; Bain, David L; Bakhtina, Marina M et al. (2015-01)
  • Characterisation of FUT4 and FUT6 α-(1 → 2)-fucosyltransferases reveals that absence of root arabinogalactan fucosylation increases Arabidopsis root growth salt sensitivity. 

    Tryfona, Theodora; Theys, Tina E; Wagner, Tanya; Stott, Katherine Mary; Keegstra, Kenneth; Dupree, Paul (2014-01)
  • Characterization of the interaction between HMGB1 and H3-a possible means of positioning HMGB1 in chromatin. 

    Watson, Matthew; Stott, Katherine Mary; Fischl, Harry; Cato, Laura; Thomas, Jean Olwen (2014-01)
  • Analysis of 13C and 14C labeling in pyruvate and lactate in tumor and blood of lymphoma-bearing mice injected with 13C- and 14C-labeled pyruvate 

    Brindle, Kevin Michael; Serrao, Eva; Kettunen, Mikko; Rodrigues, Tiago; Lewis, David; Gallagher, Ferdia Aidan; Hu, Deen
    Measurements of hyperpolarized 13C label exchange between injected [1-13C]pyruvate and the endogenous tumor lactate pool can give an apparent first order rate constant for the exchange. Determination of isotope flux, ...

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