Department of Medicine
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The PLK1 and NLRP3 interactome in NLRP3 inflammasome activation
Excessive activation of the NLRP3 inflammasome is involved in sterile inflammation in multiple chronic diseases such as atherosclerosis, gout, type 2 diabetes or Alzheimer’s disease. However, current treatment strategies ... -
Deep forward and reverse phenotyping for genetic discovery in pulmonary arterial hypertension.
Pulmonary arterial hypertension (PAH) is a rare disease characterised by constriction and obliteration of small pulmonary arteries, which leads to increased pulmonary vascular resistance and in consequence, right ventricular ... -
Portal hypertension in cirrhosis and its associated pulmonary vascular disorders
Liver disease is the third most common cause of premature death and is the only condition with mortality increasing year on year. Cirrhosis, through portal hypertension (PH), leads to complications, including pulmonary ... -
Genomic investigation of primary immunodeficiency
Primary immunodeficiencies (PIDs) are a collection of rare diseases which effect one or more components of the human immune system and are typically considered monogenic. PID presents with features including increased ...
