Department of Medicine
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Regulation of Protein Degradation at the Endoplasmic Reticulum
Endoplasmic reticulum (ER) associated degradation (ERAD) is important for removing damaged or misfolded proteins at the ER membrane, and is central to the physiological regulation of proteins such as HMG-CoA Reductase ... -
Zebrafish Mutagenesis Study of Host Determinants of Mycobacterial Infection Outcome
(2020-10-25)This thesis describes a large-scale forward genetic screen in zebrafish for host determinants of mycobacterial infection outcome that I participated in. Zebrafish larvae from families randomly mutagenized with N-ethyl-N- ... -
Screening for genes involved in CD8⁺ T cell cytotoxicity and characterisation of a super-killer
Cytotoxic T Lymphocytes (CTL) are cells of the adaptive immune system that are responsible for the elimination of virally infected, tumorigenic or damaged cells through mechanisms that induce target cell lysis. The aim of ... -
Macrophage Response to Interleukin-1 Stimulation and the Nature of Cell Surface Interleukin-1 Alpha
Interleukin-1α (IL-1α) is a potent cytokine involved in a range of diseases and can be found expressed on the cell surface (csIL-1α) and in the soluble form, signalling through the type I IL-1 receptor (IL-1R1). IL-1 ...
