Department of Medicine

Recent Submissions

  • Marginal zone B cells control the response of follicular helper T cells to a high-cholesterol diet 

    Nus, Meritxell Edurne; Sage, Andrew Philip; Lu, Yuning; Masters, L; Lam, Yee Hong; Newland, Stephen Alexander; Weller, S et al. (Springer Nature, 2017-05)
    Splenic marginal zone B (MZB) cells, positioned at the interface between circulating blood and lymphoid tissue, detect and respond to blood-borne antigens. Here we show that MZB cells in mice activate a homeostatic program ...

  • Cancer Immunotherapy Trials Underutilize Immune Response Monitoring 

    Connell, Claire; Raby, SEM; Beh, I; Flint, Thomas; Williams, EH; Fearon, DT; Jodrell, Duncan Ian et al.
    Immune‐related radiological and biomarker monitoring in cancer immunotherapy trials permits interrogation of efficacy and reasons for therapeutic failure. We report the results from a cross‐sectional analysis of response ...

  • Whole genome sequencing of ESBL-producing E. coli isolated from patients, farm waste and canals in Thailand 

    Runcharoen, C; Raven, KE; Reuter, S; Kallonen, T; Paksanont, S; Thammachote, J; Anun, S et al.
    Background: Tackling multidrug-resistant Escherichia coli requires evidence from One Health studies that capture numerous potential reservoirs in circumscribed geographic areas. Methods: We conducted a survey of extended ...

  • A novel mechanism for buffering dietary salt in humans: Effects of salt loading on skin sodium, VEGF-C and blood pressure 

    Selvarajah, Viknesh; Mäki-Petäjä, KM; Pedro, L; Bruggraber, SFA; Burling, K; Goodhart, AK; Brown, MJ et al. (Wolters Kluwer Health, 2017-11-01)
    High dietary sodium intake triggers increased blood pressure (BP). Animal studies show that dietary salt loading results in dermal Na+ accumulation and lymphangiogenesis mediated by VEGF-C (vascular endothelial growth ...

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