Recent Submissions

  • Molecular imaging of atherosclerosis with integrated PET imaging 

    Hammad, B; Evans, NR; Rudd, JHF; Tawakol, A
    Atherosclerotic diseases account for nearly half of all deaths and are leading causes of adult disability. Our understanding of how atherosclerosis leads to cardiovascular disease events has evolved: from a concept of ...
  • Basic research: Killing the old: cell senescence in atherosclerosis 

    Bennett, MR; Clarke, MCH (Nature Publishing Group, 2016-12-12)
    Atherosclerosis is a disease of ageing, and the most common cause of death in the industrialized world. Cell senescence and the therapeutic removal of senescent cells using 'senolytics' are topical areas of science and ...
  • TNFα drives pulmonary arterial hypertension by suppressing the BMP type-II receptor and altering NOTCH signalling 

    Hurst, LA; Dunmore, BJ; Long, L; Crosby, A; Al-Lamki, R; Deighton, J; Southwood, M et al. (Nature Publishing Group, 2017-01-13)
    Heterozygous germ-line mutations in the bone morphogenetic protein type-II receptor (BMPR-II) gene underlie heritable pulmonary arterial hypertension (HPAH). Although inflammation promotes PAH, the mechanisms by which ...
  • The age-dependent association between aortic pulse wave velocity and telomere length 

    McDonnell, Barry J; Butcher, Lee; Cockcroft, John R; Wilkinson, Ian B; Erusalimsky, Jorge D; McEniery, Carmel M (Wiley, 2017-01)
    Ageing is associated with marked large artery stiffening. Telomere shortening, a marker of cellular ageing, is linked with arterial stiffening. However, the results of existing studies are inconsistent, possibly because ...

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