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  Metabolic exhaustion in infection, cancer and autoimmunity 

  McKinney, Eoin Fergal; Smith, Kenneth George (Nature Publishing Group, 2018-02-05)

  It has become increasingly clear that changes in metabolism are not just consequences of T cell activation but instead are also essential drivers of that process that shape the extent and nature of differentiation and ...
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  Critical Care Health Informatics Collaborative (CCHIC): Data, tools and methods for reproducible research: A multi-centre UK intensive care database. 

  Harris, Steve; Shi, Sinan; Brealey, David; MacCallum, Niall S; Denaxas, Spiros; Perez-Suarez, David; Ercole, AriWatkinson, PeterJones, AndrewAshworth, SimonBeale, RichardYoung, DuncanBrett, StephenSinger, Mervyn et al. (Elsevier, 2018-04)

  Objective To build and curate a linkable multi-centre database of high resolution longitudinal electronic health records (EHR) from adult Intensive Care Units (ICU). To develop a set of open-source tools to make these ...
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  Prevalence and predictors of TNF-inhibitor persistence in psoriatic arthritis 

  Stober, Carmel Bernadette; Ye, W; Guruparan, T; Htut, E; Clunie, G; Jadon, D

  Objectives: To evaluate TNF-α inhibitor (TNFi) persistence when used as first- or second-line biologic therapy for the management of PsA, and to determine baseline clinical and laboratory parameters associated with TNFi ...
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  Identification of MicroRNA-124 as a Major Regulator of Enhanced Endothelial Cell Glycolysis in Pulmonary Arterial Hypertension via PTBP1 (Polypyrimidine Tract Binding Protein) and Pyruvate Kinase M2. 

  Caruso, Paola; Dunmore, Benjamin John; Schlosser, Kenny; Schoors, Sandra; Dos Santos, Claudia; Perez-Iratxeta, Carol; Lavoie, Jessie RZhang, HuiLong, LuFlockton, Amanda RFrid, Maria GUpton, Paul DavidD'Alessandro, AngeloHadinnapola, CharakaKiskin, FedirTaha, MohamadHurst, Liam AOrmiston, Mark LHata, AkikoStenmark, Kurt RCarmeliet, PeterStewart, Duncan JMorrell, Nicholas et al. (Wolters Kluwer Health, 2017-12)

  BACKGROUND: Pulmonary arterial hypertension (PAH) is characterized by abnormal growth and enhanced glycolysis of pulmonary artery endothelial cells. However, the mechanisms underlying alterations in energy production have ...

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