Department of Medicine
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Integrative statistical methods for the genomic analysis of immune-mediated disease
(2020-04-25)Genome-wide association studies (GWAS) have proved to be a successful method in cataloguing loci influencing thousands of complex human disease phenotypes. However, elucidating the causal mechanisms underlying such ... -
Energy failure following traumatic brain injury: Potential mechanisms and impact of normobaric hyperoxia
(2020-02-24)Cerebral ischaemia is a frequent finding in post mortem studies following traumatic brain injury (TBI), but clinical studies using 15oxygen positron emission tomography (15O PET) suggest that classical ischaemia is uncommon ... -
Predicting the risk of progression in patients with thoracic aortic aneurysm
(2020-01-01)This body of work has examined a range of easily quantifiable circulating biomarkers in a cohort of 50 patients with aneurysms of the arch and descending thoracic aorta. I have described within this thesis various obstacles ... -
Understanding host factors controlling intracellular killing of Mycobacterium tuberculosis
(2020-03-21)Effective stimulation of innate immunity is essential for a successful host response to infection with Mycobacterium tuberculosis (MTB) which causes human tuberculosis (TB). Better understanding of host factors controlling ...
