Department of Medicine
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Biomechanical Analysis of Human Coronary Atherosclerotic Plaques in Response to Pharmacotherapy, and in Predicting Adverse Clinical Events
Myocardial infarction, a leading cause of mortality and morbidity worldwide, is often the result of coronary plaque rupture. Previous histological work has demonstrated that ruptured plaques are associated with higher ... -
Investigating the Mechanisms Underlying the Heterogeneous VSMC Contribution to Vascular Disease
In healthy blood vessels, vascular smooth muscle cells (VSMCs) exist in a contractile, quiescent state but upon vascular insult can switch phenotype to activate proliferation, migration and remodelling of the extracellular ... -
Systems immunology frameworks link multicellular immune perturbation phenotypes and setpoints to response outcomes
This thesis develops frameworks for using top-down systems biology approaches with multiomic single cell technology to understand variation in human immune system response outcomes. We integrate human population, cell ... -
Tissue-resident immunity in the human kidney
The human kidney maintains whole organism homeostasis through tightly regulated filtration, transport, and endocrine functions that are subserved by a wide array of specialised cell types with distinct developmental origins ...
