Department of Medicine
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Working Memory after Traumatic Brain Injury: The Neural Basis of Improved Performance with Methylphenidate
(Frontiers, 2017-04-05)Traumatic brain injury (TBI) often results in cognitive impairments for patients. The aim of this proof of concept study was to establish the nature of abnormalities, in terms of activity and connectivity, in the working ... -
DNA damage-dependent mechanisms of ageing and disease in the macro- and microvasculature
(Elsevier, 2017-03-25)A decline in the function of the macro- and micro-vasculature occurs with ageing. DNA damage also accumulates with ageing, and thus DNA damage and repair have important roles in physiological ageing. Considerable evidence ... -
Statistical Techniques to Fine Map the Related Genetic Aetiology of Autoimmune Diseases
(2017-05-30)Genome Wide Association Studies (GWAS) have uncovered many genetic regions which are associated with autoimmune disease risk. In this thesis, I present methods which I have developed to build upon these studies and enable ... -
Contrasting phenotypes in Resistance to Thyroid Hormone alpha correlate with divergent properties of thyroid hormone receptor alpha1 mutant proteins
Background: Resistance to Thyroid Hormone alpha (RTHα), a disorder characterised by tissue-selective hypothyroidism and near-normal thyroid function tests due to thyroid receptor α gene mutations, is rare but probably ...
