Department of Medicine
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Evaluation of immunomodulatory mediators in chronic obstructive pulmonary disease and cardiovascular disease
Chronic obstructive pulmonary disease (COPD) and cardiovascular disease (CVD) are among the leading causes of mortality and poor health burden in the world. Both COPD and CVD often co-exist, due to shared risk factors and ... -
Exploring the therapeutic potential of the apelin receptor signalling axis, and angiotensin-converting enzyme 2 (ACE2) as the SARS-CoV-2 viral entry receptor, in the cardiovascular system
The apelin receptor is a class A GPCR that binds two endogenous peptide ligands, apelin and elabela/Toddler (ELA), to induce positive cardiac inotropy and vasodilatation in the cardiovascular system. The apelin receptor ... -
Investigating the role of mitochondria in the hypoxia response using in vitro and in vivo models
Human coiled-coil helix coiled-coil helix domain-containing protein 4 (CHCHD4) catalyses disulfide bond formation in substrate proteins, mediating their import from the cytoplasm into the mitochondria. CHCHD4 is critical ... -
Developing novel therapies for Mycobacterium abscessus
Mycobacterium abscessus (M. abscessus) is a rapid growing non-tuberculous mycobacteria (NTM) that is increasingly recognised as a major pathogen owing to its inherent resistance to a wide range of the currently available ...
