Department of Medicine
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Investigation of novel therapeutic strategies in B cell and antibody mediated disease
(2019-01-26)Terminally differentiated B cells are responsible for antibody generation, a key component of adaptive immunity. IgG antibodies play an important role in defence against infection but can be pathogenic in some autoimmune ... -
Developing an induced pluripotent stem cell model of pulmonary arterial hypertension to understand the contribution of BMPR2 mutations to disease-associated phenotypes in smooth muscle cells
(2019-01-26)Mutations in the gene encoding the bone morphogenetic protein type 2 receptor (BMPR2) are the most common genetic cause of heritable pulmonary arterial hypertension (PAH). However, given the reduced penetrance of BMPR2 ... -
Novel mechanisms for buffering the haemodynamic effects of dietary salt and the relevance of skin sodium in humans
(2018-10-20)Background: Hypertension is one of the most common diseases in the United Kingdom and it remains an important risk factor for cardiovascular morbidity and mortality. Dietary sodium is an important trigger for hypertension ... -
Development of computational approaches for whole-genome sequence variation and deep phenotyping
(2019-01-26)The rare disease pulmonary arterial hypertension (PAH) results in high blood pressure in the lung caused by narrowing of lung arteries. Genes causative in PAH were discovered through family studies and very often harbour ...
