Department of Medicine
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Atypical Mechanisms of Synthesis, Activation and Release of Interleukin-1β from Vascular Smooth Muscle Cells
Atherosclerosis is a widespread disease that often leads to serious conditions such as myocardial infarction and stroke. Chronic inflammation plays an overarching role in its pathophysiology, driving initiation and progression ... -
Characterising ATP13A3 biological function and its role in pulmonary arterial hypertension
Pulmonary arterial hypertension (PAH) is a rare but devastating disease characterised by the progressive remodelling of the small pulmonary vessels. Although the causes may vary, similar pathobiological features are shared ... -
Molecular mechanism of KAP1-dependent transcriptional silencing
Retroviruses can integrate their DNA into the host-cell genome. Inherited retroviral DNA and other transposable elements account for at least half of the human genome. Transcription of transposable elements is tightly ...
