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Defective Base Excision Repair of Oxidative DNA Damage in Vascular Smooth Muscle Cells Promotes Atherosclerosis. (Wolters Kluwer Health, 2018-04-11)Background: Atherosclerotic plaques demonstrate extensive accumulation of oxidative DNA damage, predominantly as 8-oxoguanine (8oxoG) lesions. 8oxoG is repaired by base excision repair (BER) enzymes; however, the mechanisms ...
The p38 mitogen activated protein kinase inhibitor losmapimod in chronic obstructive pulmonary disease patients with systemic inflammation, stratified by fibrinogen: A randomised double-blind placebo-controlled trial. (Public Library of Science (PLoS), 2018-01)Chronic Obstructive Pulmonary Disease (COPD) is a complex condition, which is associated with extra-pulmonary manifestations, such as systemic inflammation and cardiovascular dis- ease, that increase patient morbidity and ...
(2011-08-01)Purpose of Review: This article reviews the important aspects of managing patients undergoing anaesthesia and monitoring for MRI and PET. Recent Findings: The use of MRI and PET is expanding and an increasing number of ...