Theses - Biochemistry
About this collection
Recent Submissions
-
Structure of the trypanosome transferrin receptor and insights into ligand binding and therapeutic strategies
African trypanosomes are extracellular protozoan pathogens that have evolved a complex and sophisticated interface with hosts to acquire nutrients and protect against the host immune system. The variant surface glycoprotein ... -
Characterising fitness landscapes of protein evolution by next-generation sequencing
(2020-10-24)A protein’s amino acid sequence determines its structural, chemical and physical properties, yet how sequence variation influences protein function is still incompletely understood. Protein fitness landscapes powerfully ... -
Molecular mechanism of Trypanosoma brucei Aquaglyceroporin 2
Trypanosoma brucei subspecies cause Human African Trypanosomiasis, which is fatal unless treated. T. brucei Aquaglyceroporin 2 (TbAQP2) is required for the uptake of two of the drugs used clinically, pentamidine and ... -
Elucidating p53’s physiological and tumourigenic roles
The key role of p53 as a tumour suppressor is widely acknowledged and based on many observations that p53 suppresses oncogene-mediated transformation of rodent fibroblasts and is the most frequently mutated gene in human ...
