Theses - Biochemistry
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The Lipid-Facing M4 Helix of α4β2 nACh and 5-HT3A Receptors
Pentameric ligand-gated ion channels (pLGICs) are expressed throughout the human nervous system, and contribute to a range of muscle, gut, and neurological functions. Elucidating their mechanism of action and how it might ... -
Identification of novel regulators of the necrosis-inducing protein (Nip) and carbapenem antibiotic production in the phytopathogen Pectobacterium
Pectobacterium is a Gram-negative phytopathogen that causes soft rot and blackleg disease of potatoes. It produces plant cell wall degrading enzymes (PCWDEs) and is capable of swimming and swarming motility. Some strains ... -
Rational design and optimization of anti-Cdc42 peptide inhibitors
This thesis describes the structural and functional analysis of a series of cyclic peptides, engineered as inhibitors of the Rho-family GTPase, Cdc42. The research presented builds on previous work which selected Cdc42 ... -
The disordered N-terminus of RLIP76: a hub for protein and membrane interactions
RLIP76 is an effector for the Ral family of small GTPases. Ral proteins are themselves downstream of Ras, and Ras mutations drive around 20% of all cancers. RLIP76 has been implicated in a number of cell processes ranging ...
