Theses - Biochemistry
About this collection
Recent Submissions
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Interrogation and engineering of RAD51:BRC repeat interactions
The maintenance of genetic information is a fundamental function of every organism. The DNA in every human cell endures thousands of lesions per day, and eukaryotes have developed a sophisticated response to tackle this ... -
Structural and Mechanistic Studies of Multidrug Resistance Efflux Pumps in Multiple Families
(2021-09-16)Multidrug resistance, whereby pathogens develop resistance to several antimicrobial agents, is a large and growing public health concern globally. In order to combat its continued spread, a better understanding of resistance ... -
Role of Neuraminidase-mediated Desialylation in Microglial Activation
Microglia are the innate immune cells of the central nervous system (CNS) and play key roles in mediating the removal of dead or dying neurons, neurotoxic aggregates or neuronal debris, thus contributing to CNS health. ... -
Regulation of Mitochondrial Function by Histone Acetylation and Mitochondrial Acetyl-CoA Levels in Saccharomyces cerevisiae
Previous studies from our lab demonstrated that starvation signals transmitted by multiple kinases, including the PAS kinase Rim15, the DYRK kinase Yak1, the GSK-3 homologue Mck1 and the energy-sensing SNF1 complex, were ...
