Theses - Biochemistry
About this collection
Recent Submissions
-
The regulation of the oncogenic STAT transcription factors by the non receptor tyrosine kinase and Cdc42 effector ACK
Activated Cdc42-associated kinase (ACK) is a Rho family effector that is widely implicated in cancer, yet not currently pharmacologically inhibited in the clinic. Through relationships with the androgen receptor in prostate ... -
Unravelling the roles of the Mck1 kinase in metabolic reprogramming and the stress response
During the transition into stationary phase, S. cerevisiae cells acquire a set of characteristics that are typical of G0 cells, which include upregulation of the starvation- specific gene expression program, enhanced ... -
Metabolic regulation of denitrification in the opportunistic pathogen Pseudomonas aeruginosa
Pseudomonas aeruginosa is a World Health Organization Priority 1 human pathogen and is one of the leading bacterial species implicated in nosocomial infections, posing a significant risk to immunocompromised patients due ... -
The role of ACK in regulating the Vav family proteins
The non-receptor tyrosine kinase effector of Cdc42, ACK, has been identified as an oncogene. Aberrant expression and mutations of ACK have been found in many types of cancer, such as prostate, breast and pancreatic. ...
