Theses - Biochemistry
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Fantastic ribonucleoprotein complexes and how to study them. Architectural principles of regulatory assemblies in bacteria.
The fate of a bacterial RNA transcript is controlled by three key players: ribonucleases, RNA binding proteins (RBPs) and small regulatory RNAs (sRNAs). Together these form an information-rich regulatory network that ... -
Discovery and functional analyses of new components of the apical complex and the pellicle of Toxoplasma gondii
The pellicle of the apicomplexan parasite Toxoplasma gondii is a shared structure among the supergroup Alveolata, which consists of a patchwork of flattened vesicles underneath the plasma membrane. The apical complex, from ... -
Structure of the trypanosome transferrin receptor and insights into ligand binding and therapeutic strategies
African trypanosomes are extracellular protozoan pathogens that have evolved a complex and sophisticated interface with hosts to acquire nutrients and protect against the host immune system. The variant surface glycoprotein ... -
Characterising fitness landscapes of protein evolution by next-generation sequencing
(2020-10-24)A protein’s amino acid sequence determines its structural, chemical and physical properties, yet how sequence variation influences protein function is still incompletely understood. Protein fitness landscapes powerfully ...
