Theses - Biochemistry
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Investigating the molecular signatures of β1-adrenergic receptor activation
(2019-10-26)In this thesis I have investigated the molecular signatures of receptor activation, using the β1-adrenergic receptor (β1AR) as a prototypical class A G-protein coupled receptor (GPCR). I have used a minimally thermostabilised ... -
CHARACTERIZATION OF LOW MOLECULAR WEIGHT C-TYPE CYTOCHROMES IN CYANOBACTERIA AND PLANTS
(2019-10-26)Cytochrome c6 (Cyt c6) and Plastocyanin (Pc) are two well characterised redox carriers in the thylakoid lumen of cyanobacteria and algae. In cyanobacteria Cyt c6 or Pc shuttles electrons from the Cyt b6f complex to Photosystem ... -
The Contribution of APP gene dosage to the molecular phenotypes of Alzheimer's disease in human trisomy 21 neurons
(2019-07-19)Down syndrome is a condition caused by trisomy 21 and occurs in 1 out of 700 births. People with trisomy 21 are high risk for developing Alzheimer’s disease, a neurodegenerative disease that causes approximately 65% of ... -
Structural and biophysical analysis of Human DNA repair protein CtIP
(2019-10-19)The integrity of our genome is constantly threatened by endogenous and exogenous sources of DNA damage. The successful repair of DNA lesions is necessary for cellular survival and prevention of disease such as cancer. ...
