Theses - Biochemistry
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Recent Submissions
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Design, Off-Target Toxicity, and Intracellular Processing of Nucleotide-Modified Messenger RNAs for Human Therapies
RNA therapy is a modality, analogous to gene therapy, in which in vitro-transcribed mRNA (IVT mRNA) is introduced to cells for therapeutic applications. IVT mRNA is transfected into target cells, translated, and the ... -
Interrogations of protein and RNA: localisation, interactions and dynamics
Eukaryotic cells are characterised by a high degree of structural partitioning into distinct microenvironments dedicated to diverse and specific roles. To maintain these microenvironments, the functions of endogenous RNAs ... -
Assembly of nuclear dimers of the PI3K regulatory subunits underpins the proliferative activity of Activated Cdc42-associated Kinase, ACK
(2021-01-18)ACK is an oncogenic non-receptor tyrosine kinase associated with poor prognosis in human cancers. ACK promotes proliferation, in part, by contributing to the activation of Akt, the major PI3K effector. The work presented ... -
Characterization and targeting of the 2-methylcitrate cycle in Pseudomonas aeruginosa
(2021-08-31)Pseudomonas aeruginosa is an opportunistic human pathogen responsible for a significant proportion of hospital-acquired infections worldwide. P. aeruginosa infections are especially difficult to treat due to its numerous ...
