Theses - Medicine
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Vascular smooth muscle cell heterogeneity and plasticity in models of cardiovascular disease
(2018-07-20)Vascular smooth muscle cell (VSMC) accumulation is a hallmark of atherosclerosis and vascular injury. However, fundamental aspects of proliferation and the phenotypic changes within individual VSMCs, which underlie vascular ... -
Development of an Optogenetic Toolkit for the Interrogation of T cell Signalling Dynamics
(2018-04-20)T cells are a cornerstone of the mammalian adaptive immune system. A range of T-cell subsets exist that can orchestrate the overall immune response to pathogens or cancers, either by directly killing infected cells or ... -
Novel Proteases That Regulate Interleukin-1 Alpha Activity During Inflammation And Senescence
(2018-04-11)Interleukin-1 alpha (IL-1a) is a powerful inflammatory cytokine that modulates both innate and adaptive immunity. As such, IL-1a is implicated in the development of multiple inflammatory and autoimmune diseases including ... -
The effect of human cytomegalovirus on neutrophil survival, autophagy, and extracellular traps
(2018-04-28)Neutrophils provide a rapid first response to invading pathogens and orchestrate the immune response. They are able to employ potent antipathogenic mechanisms such as phagocytosis, reactive oxygen species (ROS) generation, ...
