Theses - Medicine
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Genomic investigation of primary immunodeficiency
Primary immunodeficiencies (PIDs) are a collection of rare diseases which effect one or more components of the human immune system and are typically considered monogenic. PID presents with features including increased ... -
Mitochondrial regulation of CD8+ T cell cytotoxicity
Recent discoveries in the field of immunometabolism have emphasised the importance of mitochondria in the context of T cell development, differentiation, signalling and exhaustion. However, the question of whether mitochondria ... -
Establishing models of and characterising the genomic context of neutrophil hypersegmentation
(2021-09-28)Neutrophils are the most prominent leukocytes in the human body and represent the first line of defence against invading pathogens. Their nuclear architecture is highly dynamic, composed of chromatin clustered into lobes ... -
The CD4⁺ T Cell Response to Human Cytomegalovirus
Human cytomegalovirus (HCMV) is a betaherpesvirus that infects most humans worldwide. In the healthy host, it elicits a broad immune response involving both the innate and adaptive arms of immunity, which is able to limit ...
