Theses - Medicine
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Recent Submissions
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3D Analysis Of The Hip Joint For The Prediction Of Osteoarthritis
(2019-05-18)Hip osteoarthritis is an increasingly important cause of morbidity in the ageing population causing pain, disability and loss of function through joint failure. It has an estimated lifetime risk of 25%. While the contribution ... -
Continuous Multi-Modal Monitoring of Cerebrovascular Reactivity in Adult Traumatic Brain Injury
(2019-04-30)Impaired cerebral autoregulation following traumatic brain injury (TBI) in adults has been linked to worse global outcome. Continuously updating indices of cerebrovascular reactivity provide a convenient and continuous ... -
Development of Novel Therapies for Marfan Syndrome using a Human iPSC-disease model
(2019-04-27)Marfan syndrome (MFS) is a connective tissue disorder caused by mutations in fibrillin-1, a matrix component encoded by the gene FBN1, with pleiotropic manifestations including severe cardiovascular complications, such as ... -
Investigating CD8+ T-cell gene expression signatures as disease prognostic biomarkers in paediatric inflammatory bowel disease.
(2019-02-05)Background: Currently, it is not possible to predict disease behaviour for children with inflammatory bowel disease (IBD), which is a major obstacle in an era where we strive to deliver personalised, tailored therapy. ...
