Theses - Medicine
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Recent Submissions
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Exploring the therapeutic potential of the apelin receptor signalling axis, and angiotensin-converting enzyme 2 (ACE2) as the SARS-CoV-2 viral entry receptor, in the cardiovascular system
The apelin receptor is a class A GPCR that binds two endogenous peptide ligands, apelin and elabela/Toddler (ELA), to induce positive cardiac inotropy and vasodilatation in the cardiovascular system. The apelin receptor ... -
Investigating the role of mitochondria in the hypoxia response using in vitro and in vivo models
Human coiled-coil helix coiled-coil helix domain-containing protein 4 (CHCHD4) catalyses disulfide bond formation in substrate proteins, mediating their import from the cytoplasm into the mitochondria. CHCHD4 is critical ... -
Developing novel therapies for Mycobacterium abscessus
Mycobacterium abscessus (M. abscessus) is a rapid growing non-tuberculous mycobacteria (NTM) that is increasingly recognised as a major pathogen owing to its inherent resistance to a wide range of the currently available ... -
B cell therapy in ANCA-associated vasculitis
Anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) is a rare autoimmune disease with a UK prevalence of 250 per million. The immunopathogenesis includes neutrophil activation by B cell-derived ANCAs, ...
