Theses - Medicine
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Assessing Disease Modifying Therapies in Autosomal Dominant Polycystic Kidney Disease
(2020-10-27)Background: Vasopressin stimulates cyst growth in autosomal dominant polycystic kidney disease (ADPKD) and is a key therapeutic target. Evaluation of high water intake (HWI) as an alternative to pharmacological vasopressin ... -
Atypical Mechanisms of Synthesis, Activation and Release of Interleukin-1β from Vascular Smooth Muscle Cells
Atherosclerosis is a widespread disease that often leads to serious conditions such as myocardial infarction and stroke. Chronic inflammation plays an overarching role in its pathophysiology, driving initiation and progression ... -
Characterising ATP13A3 biological function and its role in pulmonary arterial hypertension
Pulmonary arterial hypertension (PAH) is a rare but devastating disease characterised by the progressive remodelling of the small pulmonary vessels. Although the causes may vary, similar pathobiological features are shared ...
