Theses - Medicine
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Statistical Techniques to Fine Map the Related Genetic Aetiology of Autoimmune Diseases
(2017-05-30)Genome Wide Association Studies (GWAS) have uncovered many genetic regions which are associated with autoimmune disease risk. In this thesis, I present methods which I have developed to build upon these studies and enable ... -
Patterns and predictors of falls and their consequences in extreme old age
(Department of Public Health and Primary Care, University of Cambridge, 2007-02-13)$\textbf{BACKGROUND AND AIMS}$ Falls in old age can have serious consequences. The impact on health and social care is growing as the older population increases, but there are few data on falling amongst the “oldest old”. ... -
Utilisation of novel magnetic resonance imaging features in the diagnosis and understanding of multiple sclerosis
(Department of Clinical Neurosciences, University of Cambridge, 2016)There is no single test clinically available that is independently diagnostic for multiple sclerosis (MS). Currently MS is diagnosed using a combination of clinical evaluation and investigations including magnetic resonance ... -
Modulation of neutrophil degranulation by hypoxia
(2015-02-03)Neutrophils are key effector cells of the innate immune system. They employ a number of powerful ‘weapons’ to eliminate pathogens, including an array of destructive proteins packaged into distinctive granule subsets. In ...
