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  • SCFAs strongly stimulate PYY production in human enteroendocrine cells. 

    Larraufie, Pierre Frederic; Martin-Gallausiaux, C; Lapaque, N; Dore, J; Gribble, Fiona Mary; Reimann, Frank; Blottiere, HM (Nature Publishing Group, 2018-01-08)
    Peptide-YY (PYY) and Glucagon-Like Peptide-1 (GLP-1) play important roles in the regulation of food intake and insulin secretion, and are of translational interest in the field of obesity and diabetes. PYY production is ...
  • The metabolic syndrome- associated small G protein ARL15 plays a role in adipocyte differentiation and adiponectin secretion. 

    Rocha, Nuno Miguel; Payne, Felicity; Huang-Doran, Isabel; Sleigh, Alison; Fawcett, Katherine; Adams, Claire; Stears, Anna et al. (Nature Publishing Group, 2017-12-14)
    Common genetic variants at the ARL15 locus are associated with plasma adiponectin, insulin and HDL cholesterol concentrations, obesity, and coronary atherosclerosis. The ARL15 gene encodes a small GTP-binding protein whose ...
  • Desacetyl-α-melanocyte stimulating hormone and α-melanocyte stimulating hormone are required to regulate energy balance. 

    Mountjoy, Kathleen G; Caron, Alexandre; Hubbard, Kristina; Shome, Avik; Grey, Angus C; Sun, Bo; Bould, Sarah et al. (Elsevier, 2017-11-24)
    Objective: Regulation of energy balance depends on pro-opiomelanocortin (POMC)- derived peptides and melanocortin-4 receptor (MC4R). Alpha-melanocyte stimulating hormone (α-MSH) is the predicted natural POMC-derived peptide ...
  • Targeted intestinal delivery of incretin secretagogues-towards new diabetes and obesity therapies. 

    Gribble, Fiona Mary; Meek, Claire L; Reimann, Frank (Elsevier, 2018-02)
    A new strategy under development for the treatment of type 2 diabetes and obesity is to mimic some of the effects of bariatric surgery by delivering food-related stimuli to the distal gastrointestinal tract where they ...

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