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  • Paradoxical Sensitivity to an Integrated Stress Response Blocking Mutation in Vanishing White Matter Cells 

    Sekine, Y; Zyryanova, A; Crespillo-Casado, A; Amin-Wetzel, N; Harding, HP; Ron, D (Plos One, 2016-11-03)
    The eukaryotic translation initiation factor eIF2B promotes mRNA translation as a guanine nucleotide exchange factor (GEF) for translation initiation factor 2 (eIF2). Endoplasmic reticulum (ER) stress-mediated activation ...
  • The Sleep/Wake Cycle Is Directly Modulated by Changes in Energy Balance 

    Collet, Tinh-Hai; van der Klaauw, Agatha A.; Henning, Elana; Keogh, Julia M.; Suddaby, Diane; Dachi, Sekesai V.; Dunbar, Síle et al. (Associated Professional Sleep Societies, LLC, 2016-09-01)
    $\textbf{Study Objectives:}$ The rise in obesity has been paralleled by a decline in sleep duration in epidemiological studies. However, the potential mechanisms linking energy balance and the sleep/wake cycle are not well ...
  • Eating behaviour and metabolism in amyotrophic lateral sclerosis and frontotemporal dementia: providing insights for neurodegeneration 

    Ahmed, Rebekah M.; Irish, Muireann; Piguet, Olivier; Halliday, Glenda M.; Ittner, Lars M.; Farooqi, Sadaf; Hodges, John R. et al. (Elsevier, 2016-01-26)
    Metabolic changes incorporating fluctuations in weight, insulin resistance, and cholesterol concentrations have been identified in several neurodegenerative disorders. Whether these changes result from the neurodegenerative ...
  • Biological bases of eating behavior disturbance in frontotemporal dementia 

    Ahmed, Rebekah M.; Irish, Muireann; Henning, Elana; Dermody, Nadene; Bartley, Lauren; Kiernan, Matthew C.; Piguet, Olivier et al. (American Medical Association, 2016-03-01)
    Importance Abnormal eating behaviors are common in patients with frontotemporal dementia (FTD), yet their exact prevalence, severity, and underlying biological mechanisms are not understood. Objective To define the ...

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