Babraham Institute
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Undertakes innovative biomedical research to discover the molecular mechanisms that underlie normal cellular processes and functions, and how, over lifetime, their failure or abnormality may lead to disease
The Babraham Institute is located six miles south-east of the university city of Cambridge, UK. We undertake innovative biomedical research to discover the molecular mechanisms that underlie normal cellular processes and functions, and how, over lifetime, their failure or abnormality may lead to disease. The Institute is a registered charity, sponsored by the Biotechnology and Biological Sciences Research Council (BBSRC), to underpin its national responsibilities for healthcare research and training.
Our research is also supported by the Medical Research Council (MRC) and many medical charities and other organisations.
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The Rac-GEF P-Rex1 Regulates Agonist-Induced GPCR Trafficking
P-Rex guanine-nucleotide exchange factors (GEFs) activate the small GTPase Rac following stimulation of a variety of cell surface receptors, including G protein-coupled receptors (GPCRs). By activating Rac, P-Rex proteins ... -
Investigating the role of the Polycomb Repressive Complex 2 in human in vitro pancreatic differentiation
The potential to use human pluripotent stem cells in regenerative medicine is an idea that continues to excite and captivate much of the science community, decades after the initial discovery of human embryonic stem cells. ... -
Modelling metabolic landscapes in human naive and primed embryonic stem cells
Early mammalian embryos undergo remarkable changes in their metabolism, with a global transition from oxidative phosphorylation to glycolysis as they transit out of pluripotency and begin to make the first cell fate decisions ... -
The role of the PWWP domain in the DNA methyltransferase 3A targeting to the genome
All cells in a mammalian body share the same DNA content but have a distinct appearance and function. This is achieved by activation and repression of genes by epigenetic mechanisms, which are crucial for stable differentiation ...
