Babraham Institute
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Undertakes innovative biomedical research to discover the molecular mechanisms that underlie normal cellular processes and functions, and how, over lifetime, their failure or abnormality may lead to disease
The Babraham Institute is located six miles south-east of the university city of Cambridge, UK. We undertake innovative biomedical research to discover the molecular mechanisms that underlie normal cellular processes and functions, and how, over lifetime, their failure or abnormality may lead to disease. The Institute is a registered charity, sponsored by the Biotechnology and Biological Sciences Research Council (BBSRC), to underpin its national responsibilities for healthcare research and training.
Our research is also supported by the Medical Research Council (MRC) and many medical charities and other organisations.
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Exploring functional significance of asymmetric DNA methylation in early mammalian development
(The Babraham Institute, 2014-09)DNA methylation is an epigenetic modification important for the regulation of transcriptional activity in processes like genomic imprinting, retrotransposon silencing and centromeric stabilisation. It is also crucial for ... -
DISSECTING THE FUNCTION AND INTERACTOME OF PLEKHS1 IN PROSTATE TUMORIGENESIS
(2021-07-16)Phosphatidylinositol(3,4,5)trisphosphate (PI(3,4,5)P3 or PIP3) is the lipid product and key signalling output of Class I phosphoinositide 3-kinases (PI3Ks) and acts as a coordinator of a huge network that controls cellular ... -
Genetic screens of RNA binding proteins identify a role for N6-methyladenosine in promoting B cell differentiation
Post-transcriptional regulation of gene expression is mediated in part by RNA binding proteins (RBPs). Roles for RBPs have emerged in the immune system but remain largely unexplored. My project utilised high-throughput ... -
Heterogeneity and Impaired IGF1R Signalling in Aged B cell Development
B cells are a vital component of humoral immunity. Upon activation, their immunoglobulin B cell receptor (BCR) is secreted as antibody to neutralise pathogens or mediate the immune response. A diverse repertoire of ...
