Babraham Institute
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Undertakes innovative biomedical research to discover the molecular mechanisms that underlie normal cellular processes and functions, and how, over lifetime, their failure or abnormality may lead to disease
The Babraham Institute is located six miles south-east of the university city of Cambridge, UK. We undertake innovative biomedical research to discover the molecular mechanisms that underlie normal cellular processes and functions, and how, over lifetime, their failure or abnormality may lead to disease. The Institute is a registered charity, sponsored by the Biotechnology and Biological Sciences Research Council (BBSRC), to underpin its national responsibilities for healthcare research and training.
Our research is also supported by the Medical Research Council (MRC) and many medical charities and other organisations.
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The role of the PWWP domain in the DNA methyltransferase 3A targeting to the genome
All cells in a mammalian body share the same DNA content but have a distinct appearance and function. This is achieved by activation and repression of genes by epigenetic mechanisms, which are crucial for stable differentiation ... -
Promoting multi-omic rejuvenation in human and mouse somatic cells by transient reprogramming
Ageing can be defined as the gradual decline in fitness that occurs in most organisms. The ageing process is characterised by a variety of hallmarks at the cellular and molecular levels including alterations in the epigenome. ... -
ATG8 Regulation and Function in Non-Canonical Autophagy
Canonical autophagy is a fundamental, catabolic process that targets cytoplasmic components for lysosomal degradation. In a defining step of this pathway, ATG8 subfamily proteins (LC3s and GABARAPs) are recruited to double ... -
Variable DNA methylation in the mouse genome: repetitive elements, unique regions and functional implications
Approximately 10% of the mouse genome consists of endogenous retroviruses (ERVs), a class of retrotransposon, which includes the murine-specific intracisternal A particle (IAP) elements. To prevent their mobilisation and ...
