Babraham Institute
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Undertakes innovative biomedical research to discover the molecular mechanisms that underlie normal cellular processes and functions, and how, over lifetime, their failure or abnormality may lead to disease
The Babraham Institute is located six miles south-east of the university city of Cambridge, UK. We undertake innovative biomedical research to discover the molecular mechanisms that underlie normal cellular processes and functions, and how, over lifetime, their failure or abnormality may lead to disease. The Institute is a registered charity, sponsored by the Biotechnology and Biological Sciences Research Council (BBSRC), to underpin its national responsibilities for healthcare research and training.
Our research is also supported by the Medical Research Council (MRC) and many medical charities and other organisations.
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Elucidating the molecular mechanisms of p110δ activation in T cell antigen receptor signalling
(2019-05-18)Phosphoinositide 3-kinases (PI3Ks) are activated in immune cells downstream of the antigen recognition receptors, the signals from which are crucial for the development, differentiation and activation of lymphocytes. ... -
Activation and Maintenance of Intestinal Intraepithelial Lymphocytes (IELs)
(2019-04-27)The intestinal tissue is charged with a delicate immunological task. The intestinal immune system needs to be tolerant towards nutrients and microbiota present in the intestinal lumen, while simultaneously detecting and ... -
Towards systems pharmacology models of druggable targets and disease mechanisms
(2019-07-20)The development of essential medicines is being slowed by a lack of efficiency in drug development as ninety per cent of drugs fail at some stage during clinical evaluation. This attrition in drug development is seen not ... -
Follicular Regulatory T cell migration and differentiation
(2019-05-18)The germinal centre (GC) response is critical for generating highly effective humoral immune responses and immunological memory that forms the basis of successful immunisation. Control of the output of the GC response ...
