Babraham Institute
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Undertakes innovative biomedical research to discover the molecular mechanisms that underlie normal cellular processes and functions, and how, over lifetime, their failure or abnormality may lead to disease
The Babraham Institute is located six miles south-east of the university city of Cambridge, UK. We undertake innovative biomedical research to discover the molecular mechanisms that underlie normal cellular processes and functions, and how, over lifetime, their failure or abnormality may lead to disease. The Institute is a registered charity, sponsored by the Biotechnology and Biological Sciences Research Council (BBSRC), to underpin its national responsibilities for healthcare research and training.
Our research is also supported by the Medical Research Council (MRC) and many medical charities and other organisations.
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Exploiting tumour cell dependency on pro-survival BCL2 proteins with BH3 mimetics
The RAS-RAF-MEK1/2-ERK1/2 signalling pathway is one of the most frequently deregulated pathways in human cancer, with mutations in KRAS and BRAF commonly occurring in cancers of the pancreas, skin, and colon, among others. ... -
The Regulation of UHRF1 during Mammalian Embryogenesis
Mammalian embryogenesis comprises two independent instances of global DNA demethylation that each coincide with an increase in developmental potential: firstly during the development of the inner cell mass from the gametes, ... -
Phenotypic and transcriptomic consequences of ribosomal DNA copy number variation in Caenorhabditis elegans and Saccharomyces cerevisiae
Ribosomal DNA (rDNA) forms the template for mature ribosomal RNA (rRNA) and shows considerable sequence conservation through evolution. In eukaryotic genomes rDNA is present in one or more tandem repeat arrays, with copy ... -
Defining novel targets and functions of the protein kinase DYRK2
(2020-07-17)Protein post-translational modifications (PTMs) are an essential and conserved mechanism that allows eukaryotic cells to coordinate rapid responses to changing environmental conditions. Protein kinases, comprising a large ...
