Babraham Institute
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Undertakes innovative biomedical research to discover the molecular mechanisms that underlie normal cellular processes and functions, and how, over lifetime, their failure or abnormality may lead to disease
The Babraham Institute is located six miles south-east of the university city of Cambridge, UK. We undertake innovative biomedical research to discover the molecular mechanisms that underlie normal cellular processes and functions, and how, over lifetime, their failure or abnormality may lead to disease. The Institute is a registered charity, sponsored by the Biotechnology and Biological Sciences Research Council (BBSRC), to underpin its national responsibilities for healthcare research and training.
Our research is also supported by the Medical Research Council (MRC) and many medical charities and other organisations.
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Environmental stimuli shape adaptive immunity by enhancing T helper cell differentiation and the germinal centre response
(2019-07-20)Immune cells have evolved to respond to external danger signals and to incorporate information about environmental cues to adapt their differentiation and effector function. Because of this, it is important that immune ... -
ERK1/2 signalling and protein ubiquitylation in the control of apoptosis
(2019-07-19)Programmed cell death, or apoptosis, is critical for normal developmental processes that involve cell turnover including embryogenesis and development and function of the immune system. It is preceded by classical changes ... -
T cell phenotyping of a mouse model of Activated PI3Kdelta syndrome
(2019-07-20)Activated PI3Kdelta Syndrome (APDS) is immunodeficiency caused by a heterozygous gain-of-function mutation (E1021K) in the PIK3CD gene, encoding for the p110delta catalytic subunit of phosphoinositide 3-kinase (PI3K). APDS ... -
Novel mechanisms of Atg16L1 recruitment in non-canonical autophagy
(2019-07-31)Autophagy is a well-studied catabolic process through which cytoplasmic components are targeted for lysosomal degradation by autophagosomes. A key step in this process is the recruitment, processing and lipidation of LC3 ...
