Theses - Babraham Institute
About this collection
The interplay of global chromosomal organisation, promoter-enhancer interactions and transcription (2020-04-24)All somatic cells within an organism contain the same genetic material, yet they display pronounced differences in function and morphology. Precise control of gene expression is of fundamental importance to allow cells to ...
The RAS-RAF-MEK1/2-ERK1/2 signalling pathway is one of the most frequently deregulated pathways in human cancer, with mutations in KRAS and BRAF commonly occurring in cancers of the pancreas, skin, and colon, among others. ...
Mammalian embryogenesis comprises two independent instances of global DNA demethylation that each coincide with an increase in developmental potential: firstly during the development of the inner cell mass from the gametes, ...