Department of Pathology
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Studying lung development in vitro: expanding the genetic toolbox and analysis of SOX2 and SOX9 function
Respiratory disease is a growing threat to human health worldwide. Induced pluripotent stem cell (iPSC) based stem cell therapy is promising for end-stage respiratory disease patients. Generation of mature/functional lung ... -
ALK in the pathogenesis of cancer
Anaplastic Lymphoma Kinase (ALK) has been implicated in the pathogenesis of many types of cancer including Anaplastic Large Cell Lymphoma (ALCL) and neuroblastoma (NB). ALK is an ideal drug target as its endogenous expression ... -
Characterisation of RNA modifications in human cancer cells
Chemical modifications have been studied as key modulators of RNA biology for over 50 years. There are now 171 RNA modifications that have been discovered throughout the three kingdoms of life1. These chemical changes ... -
Identification of host cellular factors that regulate human norovirus replication
The human norovirus (HuNoV) is one of the most predominant causes of gastroenteritis, yet no suitable therapeutics are available for its control. Currently, our knowledge of the precise cellular processes that control its ...
