Theses - Pathology
About this collection
Recent Submissions
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Mechanistic analysis of the Zika virus translation-replication switch
(2020-02-22)The genomes of positive-sense RNA viruses are required for both translation and replication during infection. These two processes are antagonistic in nature, each requiring the RNA template in opposite directions. Thus, ... -
Driver genes, mutational signatures and the timing of mutations in oesophageal adenocarcinoma
(2020-02-22)The development of oesophageal adenocarcinoma (OAC) from Barrett’s oesophagus provides an excellent model of the step-wise progression of malignancy. This process is strongly associated with the reflux of stomach contents ... -
Innate sensing and regulation during enteric caliciviruses infections
(2019-07-27)Several decades after the discovery of the human norovirus, with thousands of lives and billions of dollars lost, the lack of a robust cell culture system still severely hampers development of vaccines and therapeutics. ... -
Understanding antigen processing in chickens using genome editing technology
(2019-07-20)The major histocompatibility complex (MHC) plays crucial roles in many biological processes, most especially disease resistance. Classical MHC molecules are extremely polymorphic and encode cell surface glycoproteins that ...
