Theses - Pathology
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Sensing Foreign DNA: The Role of DNA-PKcs in Human Anti-viral Innate Immunity
Host cell pattern recognition receptors (PRRs) are a first line of defence against pathogens and function to generate a productive innate immune response. PRRs sense pathogen-associated molecular patterns (PAMPs), such as ... -
The transcriptional programme of natural killer (NK) cell functional maturation and maintenance
Natural killer (NK) cells are critical to immune surveillance against infections and cancer. Their role in immune surveillance requires that NK cells are present within tissues in a quiescent state. The functional maturation ... -
Ubiquitination of proteins involved in metabolism and immunomodulatory drug sensitivity in lymphocytes
Proteins undergo post-translational modifications, such as ubiquitination and phosphorylation, which can alter their activity, localisation and stability, making a cell responsive to its internal and external environment. ... -
Dedifferentiation of muscle cells during Trichinella spiralis infection
The first stage larvae (L1) of the obligate parasitic nematode Trichinella spiralis invades host skeletal muscle cells and reside intracellularly. The host cell is dedifferentiated, losing its muscular specialisation, and ...
