Theses - Pathology
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Control of chromatin accessibility during CD4+ T cell development and activation
T cells coordinate immune functions by differentiating into highly specialised cellular lineages that either promote or suppress immune reactions. Whereas effector T (Teff) cells drive immune activation and promote clearance ... -
LUBAC is required for the RIG-I mediated antiviral response
RNA viruses are responsible for many of the most recent threats to human health by emerging infectious diseases, including epidemics caused by Influenza, Zika, Dengue and novel Coronaviruses. The body’s first line of defence ... -
Ribosome profiling of porcine reproductive and respiratory syndrome virus reveals novel features of viral gene expression
Porcine reproductive and respiratory syndrome virus (PRRSV) is an arterivirus which causes significant economic losses to the swine industry worldwide. Here, the viral translatome was characterised using ribosome profiling ... -
Towards smart molecular biosensors: Modulation of DNA strand displacement reactions with transcription factors for robust and tunable arsenic quantification
Biosensors are increasingly important for gathering information in modern life. Advances in synthetic biology tools, such as isothermal DNA amplification, CRISPR-Cas and DNA strand displacement (DSD), have accelerated this ...
