Theses - Pathology
About this collection
Recent Submissions
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On the expression, function and regulation of the murine Ifit family of antiviral RNA-binding proteins.
(2020-01-25)IFIT proteins are highly expressed as part of the cell-intrinsic immune response following viral infection. In humans, IFIT1 inhibits translation at the initiation stage by binding directly to the 5' terminus of foreign ... -
Mechanistic analysis of the Zika virus translation-replication switch
(2020-02-22)The genomes of positive-sense RNA viruses are required for both translation and replication during infection. These two processes are antagonistic in nature, each requiring the RNA template in opposite directions. Thus, ... -
Driver genes, mutational signatures and the timing of mutations in oesophageal adenocarcinoma
(2020-02-22)The development of oesophageal adenocarcinoma (OAC) from Barrett’s oesophagus provides an excellent model of the step-wise progression of malignancy. This process is strongly associated with the reflux of stomach contents ... -
Innate sensing and regulation during enteric caliciviruses infections
(2019-07-27)Several decades after the discovery of the human norovirus, with thousands of lives and billions of dollars lost, the lack of a robust cell culture system still severely hampers development of vaccines and therapeutics. ...
