Theses - Pathology
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The elaborate interplay of natural killer cells and vaccinia virus
Vaccinia virus (VACV) is a poxvirus and is the vaccine used to eradicate smallpox. It is also an expression vector for heterologous antigens and an oncolytic virus for cancer therapy. VACV encodes multiple proteins that ... -
Vaccinia virus BTB-Kelch proteins
Vaccinia virus (VACV) is a valuable tool to study host-virus interactions and encodes a plethora of immunomodulatory proteins, among which three, A55, C2 and F3, have a BTB/BACK-Kelch (BBK) structure and are the focus of ... -
The role of the class III phosphoinositide 3-kinase VPS34 in regulatory T cells and activated CD8+ T cells
The class III PI3-kinase VPS34 is a mediator of endocytosis, trafficking of intracellular membranes and vesicles, and autophagy in various cell types. Given its central role in key cellbiological processes, we explored ... -
Harnessing synergy between BCL6 and PI3Kδ to generate a new mouse model for lymphoma
Signalling through the phosphoinositide 3-kinase (PI3K) pathway is critical for immune cell development and function. Patients with a gain of function mutation in PI3Kδ, called Activated PI3Kδ syndrome (APDS) commonly ...
