Medical Research Council and Wellcome Trust
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Structure and Function of the ER-Membrane Complex
(2020-06-17)The ER-Membrane Complex (EMC) is a highly conserved heterodecameric membrane protein complex, found in the Endoplasmic Reticulum (ER) across almost all branches of eukaryotic life. The EMC has been implicated in a wide ... -
Studies of PARP-1 activation and inhibition using NMR spectroscopy
Poly(ADP-ribose)polymerase 1 (PARP-1) is a highly abundant multi-domain chromatin-associated enzyme found in all higher eukaryotic cell nuclei. It is the founding member of the PARP family of enzymes that modify themselves ... -
Genetic dissection of circuits underlying the modular structure of the Superior Colliculus
(2020-05-16)In order to successfully interact with the environment, animals need to produce accurate movements towards specific positions in space. A crucial region of the brain that guides such goal-oriented movements is the superior ... -
Circadian Orchestration of the Cellular Proteome
(2020-01-31)Circadian rhythms are biological oscillations with a period length of roughly 24 hours. They confer an adaptive advantage as they enable the prediction of the regular environmental changes caused by the rotation of the ...
