Medical Research Council and Wellcome Trust
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HIV needs the small molecule IP6 to build its capsid
The retrovirus Human Immunodeficiency Virus Type-1 (HIV-1) infects cells of the immune system causing their depletion and resulting in the Acquired Immunodeficiency Syndrome (AIDS). The viral capsid protein (CA) is essential ... -
Evolution and Engineering of RNA-based Macromolecular Machines
The “RNA World Hypothesis” posits that extant life was likely preceded by a simpler primordial biology lacking DNA and proteins, relying instead on RNA for both heredity and catalysis. An essential component of an RNA world ... -
In vitro reconstitution of Central Spindle Motility
Precise localisation of intracellular organelles impacts a myriad of cellular processes including cell motility, polarisation and mitosis. Positioning is actively controlled by organelle specific attachment, often involving ... -
The physical origins of specimen movement in electron cryomicroscopy and how to eliminate it
Electron cryomicroscopy (cryoEM) is an important imaging technique for determining the atomic structures of biological macromolecules and complexes. Success in determining a structure by cryoEM depends on being able to ...
