Medical Research Council and Wellcome Trust
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The ubiquitin coat of cytosol-invading bacteria
(2019-10-26)Cytosol-invading Salmonella enterica serovar Typhimurium are labelled with a ubiquitin coat, which serves the dual purpose of targeting bacteria to autophagy-mediated degradation and locally inducing pro-inflammatory ... -
Bayesian modelling and sampling strategies for ordering and clustering problems with a focus on next-generation sequencing data
(2019-07-20)This thesis presents novel methods for ordering and clustering problems. The first two parts focus on the development of models and sampling strategies specifically tailored for next-generation sequencing data. Most ... -
Substrate recognition by the 26S proteasome
(2020-05-16)The 26S proteasome is a large protein complex found in all eukaryotes. It controls the degradation of a wide range of proteins in the cell, and thus it is crucial for homeostasis, regulated cell division and apoptosis. It ... -
In vitro diversification of chimeric human/chicken antibodies
(2019-10-30)Cells that constitutively diversify their immunoglobulin genes can be used for selection of novel antibodies and refining affinities and specificities of existing ones (Cumbers et al., 2002). The chicken derived DT40 B ...
