Medical Research Council and Wellcome Trust
About this community
Sub-communities within this community
Recent Submissions
-
Fanconi Anaemia DNA crosslink repair factors protect against LINE-1 retrotransposition during mammalian development
Long interspersed nuclear element 1 (LINE-1) is the only autonomous retrotransposon in humans and represents 17% of the genome. LINE-1 retrotransposition occurs by a “copy and paste” mechanism in which an RNA intermediate ... -
Cryo-EM studies of class A GPCRs: the thyroid-stimulating hormone receptor and the β1-adrenoceptor
G protein-coupled receptors (GPCRs) are integral membrane proteins with seven transmembrane domains. They are essential in intercellular communication in human physiology and represent important drug targets in human ... -
Characterising the factors involved in ER-to-Golgi anterograde trafficking
The Golgi apparatus is a major hub of protein transport, modification and sorting. Secreted and membrane proteins are synthesised in the Endoplasmic Reticulum (ER) and are packaged into carrier vesicles at ER exit sites. ... -
How is Ataxia-Telangiectasia Mutated Protein Kinase Activated?
Ataxia-Telangiectasia Mutated (ATM) is a key protein kinase in the cell’s response to double-stranded breaks in DNA. This damage is detected by the Mre11-Rad50-Nbs1 (MRN) complex, which recruits ATM to the DNA. Upon ...
