Medical Research Council and Wellcome Trust
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Structural insights into the folding of cohesin and the membrane binding of bactofilin
Cohesin is a highly conserved eukaryotic complex that performs two essential cellular functions: sister chromatid cohesion and DNA loop extrusion. As such, they involve the association and translocation of cohesin along ... -
Structure and activation of the class D GPCR dimer Ste2
G protein-coupled receptors (GPCRs) are eukaryotic membrane proteins that perform a broad range of cell signalling functions and are targets for approximately one-third of all FDA- approved drugs. GPCRs are divided ... -
Aldehyde-driven transcriptional stress triggers an anorexic DNA damage response
The genome is subjected to many forms of attack that can compromise its stability. Such forms of attack can emerge from endogenous or exogenous sources and must be counteracted by specialised repair pathways. Indeed, the ...
