Medical Research Council and Wellcome Trust
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Recent Submissions
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Identification and characterisation of new factors and mechanisms regulating human cytochrome c oxidase biogenesis
(2019-05-18)Assembly of the mitochondrial complex IV (CIV) or cytochrome c oxidase (COX) is an intricate and highly regulated process in which the three-core mitochondrial DNA (mtDNA) encoded subunits assemble in a coordinated way ... -
Genetic approaches to identifying causal pathways to cardiometabolic diseases
(2019-06-15)Background: In the era of large-scale biobanks and detailed multi-omic and clinical phenotyping, it is now possible to simultaneously measure several thousands of biological traits and test their associations with health ... -
New statistical perspectives on efficient Big Data algorithms for high-dimensional Bayesian regression and model selection
(2019-04-27)This thesis is focused on the development of computationally efficient procedures for regression modelling with datasets containing a large number of observations. Standard algorithms be prohibitively computationally ... -
Evidence Synthesis and targeting further research for adherence and stratification in health economic evaluations
(2019-04-27)Cost-effectiveness analysis (CEA) models, used to make health policy decisions, are usually subject to uncertainty. This thesis aims to develop statistical methods to quantify uncertainty and target where reducing uncertainty ...
