Medical Research Council and Wellcome Trust
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DNA crosslink repair safeguards genomic stability during pre-meiotic germ cell development
Germ cells are single-handedly responsible for the transmission of genetic and epigenetic information (the instructions to make new life) from one generation to the next. It is therefore, of paramount importance that germ ... -
Visualisation of dynein complexes in vitro and inside cells
Proper neuronal function relies on efficient transport within axons and dendrites, the long processes which extend from neuronal cell bodies. Within neuronal processes, the microtubule cytoskeleton provides tracks for ... -
Functional and Transcriptional Heterogeneity of the Human Haematopoietic Stem Cell Pool at Steady-State and Under Inflammation
(2021-02-10)Blood production is coordinated by a functionally heterogeneous pool of multipotent haematopoietic stem cells (HSCs), downstream of which lineage-restricted progenitors are generated. The advent of single cell technologies ... -
Genetic analysis of dynein function in the nervous system and in mitosis
Cytoplasmic dynein-1 is an essential microtubule-based molecular motor. Aided by several adaptors and co-factors, dynein orchestrates retrograde transport of diverse cargoes in interphase cells and plays multiple roles in ...
