Medical Research Council and Wellcome Trust
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Molecular Mechanisms of Mitotic Checkpoint Complex Assembly onto Kinetochores
(2022-05-21)During metaphase, in response to improper kinetochore-microtubule attachments, the spindle assembly checkpoint (SAC), activates the mitotic checkpoint complex (MCC), to inhibit the E3 ubiquitin ligase, the anaphase-promoting ... -
Keeping It Together and Taking It Apart: Structural Investigations of Replisome Complexes Involved in DNA Replication Fork Protection and Termination
DNA replication is an essential cellular process whose dysregulation is implicated in severe human disease, including cancer. Broadly, DNA replication involves the unwinding of the DNA double-helix, allowing DNA polymerases ... -
Structural and Spatiotemporal Organisation of Bax and Apaf1 during Apoptosis
In this thesis, I present insights into the structural, spatiotemporal and functional characteristics of two essential steps of apoptosis, Bax cluster formation and Apaf1 activation, using a combination of biochemical and ... -
The Role of Zasp52 in the Morphogenesis of the Drosophila melanogaster Embryo
Actomyosin cables are supracellular structures present during the development of many metazoans. After their initial description during wound healing in chick embryos, they have now been observed in diverse morphogenetic ...
