Medical Research Council and Wellcome Trust
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Neural Prediction Errors Distinguish Perception and Misperception of Speech
Humans use prior expectations to improve perception, especially of sensory signals that are degraded or ambiguous. However, if sensory input deviates from prior expectations, correct perception depends on adjusting or ... -
An inhibitor of oxidative phosphorylation exploits cancer vulnerability.
(Springer Nature, 2018-06-11)Metabolic reprograming is an emerging hallmark of tumor biology and an actively pursued opportunity in oncology drug discovery. Extensive efforts have focused on therapeutic targeting of glycolysis, whereas drugging ... -
Conditionally unbiased estimation in the normal setting with unknown variances
To efficiently and completely correct for selection bias in adaptive two-stage trials, uniformly minimum variance conditionally unbiased estimators (UMVCUEs) have been derived for trial designs with normally distributed ... -
SURF1 knockout cloned pigs: Early onset of a severe lethal phenotype.
(Elsevier, 2018-06)Leigh syndrome (LS) associated with cytochrome c oxidase (COX) deficiency is an early onset, fatal mitochondrial encephalopathy, leading to multiple neurological failure and eventually death, usually in the first decade ...
