Medical Research Council and Wellcome Trust
About this community
Sub-communities within this community
Recent Submissions
-
Developing drugs to attenuate succinate accumulation and oxidation
(2019-04-27)Ischaemia-reperfusion (IR) injury is caused by the re-introduction of oxygen to organs, following periods of reduced blood flow (ischaemia). Whilst re-establishing blood flow (reperfusion) to the heart following myocardial ... -
Penalised regression for high-dimensional data: an empirical investigation and improvements via ensemble learning
In a wide range of applications, datasets are generated for which the number of variables p exceeds the sample size n. Penalised likelihood methods are widely used to tackle regression problems in these high-dimensional ... -
Studies on assembly and genetic variation in mitochondrial respiratory complex I
(2019-03-30)Complex I (NADH:ubiquinone oxidoreductase) couples electron transfer to proton translocation across the inner mitochondrial membrane, to drive the synthesis of ATP. Its distinctive L-shaped structure comprises 45 subunits, ... -
Probing RNA binding specificities of AID/APOBEC proteins by iCLIP
(2019-01-31)The AID/APOBEC protein family comprises a group of cytosine deaminases found in vertebrates that are capable of modifying cytosine to uracil in the context of RNA or singlestranded DNA. They exert diverse valuable physiological ...
