Medical Research Council and Wellcome Trust
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Functional and behavioural characterisation of C. elegans acid-sensing DEG/ENaCs
The overarching aim of this thesis was to investigate how proton-sensitive members of the C. elegans DEG/ENaC family regulate cellular processes and drive behaviour. In the initial screen, I identified five C. elegans ... -
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Identification and functional characterisation of synaptic AMPA receptor-interacting proteins
Neuronal communication occurs at specialised sites, known as synapses. Presynaptic neurotransmitter release from one neuron acts on the postsynaptic receptors of another, facilitating transfer of electrical impulses between ... -
DNA crosslink repair safeguards genomic stability during pre-meiotic germ cell development
Germ cells are single-handedly responsible for the transmission of genetic and epigenetic information (the instructions to make new life) from one generation to the next. It is therefore, of paramount importance that germ ...
