Department of Veterinary Medicine
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Caspase isoforms in inflammasome activation
(2020-04)Inflammasomes are macromolecular signalling platforms composed of a receptor (for example NLRP3 or NLRC4), an adaptor (ASC) and effectors (caspases) that are thought to play critical roles in the host defence against ... -
Using mathematical models to evaluate and inform immunisation strategies with MenAfriVac in the African meningitis belt
The countries of the African meningitis belt suffer from frequent epidemics due to meningococcal meningitis. The introduction of a tailor-made vaccine, known as MenAfriVac, in these countries through mass campaigns of 1-29 ... -
The somatic evolution of the canine transmissible venereal tumour
(2020-09-01)This dissertation investigates the evolution of the canine transmissible venereal tumour (CTVT), a sexually transmitted cancer which manifests as genital tumours in dogs. This cancer first arose in an individual dog several ... -
A novel bioinformatic approach for comprehensive genome scale analysis identifies key regulators of macrophage activation.
(2020-10-17)The initiation of inflammatory cytokine transcription by bacterial ligands is a central mechanism by which the immune system activates its first line of defense. Macrophage activation by the Toll-like Receptor 4 (TLR4) ...
