Department of Veterinary Medicine
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The somatic evolution of the canine transmissible venereal tumour
(2020-09-01)This dissertation investigates the evolution of the canine transmissible venereal tumour (CTVT), a sexually transmitted cancer which manifests as genital tumours in dogs. This cancer first arose in an individual dog several ... -
A novel bioinformatic approach for comprehensive genome scale analysis identifies key regulators of macrophage activation.
(2020-10-17)The initiation of inflammatory cytokine transcription by bacterial ligands is a central mechanism by which the immune system activates its first line of defense. Macrophage activation by the Toll-like Receptor 4 (TLR4) ... -
Exploring the impact of gastrointestinal parasitic helminths on the human microbiome using advanced biomolecular and bioinformatics technologies
(2019-10-19)Our understanding of the biology of human gastrointestinal (GI) parasitic helminths is greater than ever before. However, so far, the research has focused on gene expression profiling, immune- and protein-protein interactions ... -
Origin, evolution, and global spread of a transmissible cancer clone
(2019-10-26)Clonally transmissible cancers are malignant cellular clones that spread between unrelated individuals by the physical transfer of living cancer cells. These clones can ‘metastasise’ through populations, having adapted to ...
