Department of Physiology, Development and Neuroscience
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Development of an in vitro human lung organoid system to study alveolar type 2 stem cell maintenance and dysfunction during disease The human adult distal lung parenchyma is maintained by alveolar type 2 (hAT2) cells that have the ability to self-renew and differentiate into alveolar type 1 (hAT1) cells, a critical cell type involved in gas-exchange. ...
Signalling pathways are key to virtually every aspect of the biology of multicellular organisms. Extensive research in Drosophila melanogaster has greatly contributed to the understanding of these pathways, but a central ...