Department of Physiology, Development and Neuroscience
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Investigating Cellular and Molecular Mechanisms of Neuronal Layering in Self-Organising Aggregates of Zebrafish Retinal Cells
(2018-10-20)The central nervous system is a complex, yet well-organised, often laminated, tissue. This robust organisation is evident in the architecture of the retina: consisting of 5 different neuronal types organised into distinct ... -
A PAX5-OCT4-PRDM1 developmental switch specifies human primordial germ cells.
(Springer Nature, 2018-06)Dysregulation of genetic pathways during human germ cell development leads to infertility. Here, we analysed bona fide human primordial germ cells (hPGCs) to probe the developmental genetics of human germ cell specification ... -
In vitro generation of mouse polarized embryo-like structures from embryonic and trophoblast stem cells
Mammalian embryogenesis requires the coordination of embryonic and extra-embryonic tissues to enable implantation into the uterus and post-implantation development to establish the body plan. Mouse embryonic stem cells ... -
In vivo and in vitro guidance of developing neurons by mechanical cues
(2018-10-20)During nervous system development, growing axons navigate towards their targets using signals from their environment. These signals may be biochemical or mechanical in nature; however, the role of mechanical cues in axon ...
