Department of Physiology, Development and Neuroscience
About this community
Sub-communities within this community
Collections in this community
Recent Submissions
-
Defining the minimal and context-dependent signalling cascades regulating the maintenance of human naïve embryonic stem cells and early embryo development
Human naïve embryonic stem (HNES) cells can self-renew under defined culture conditions and closely resemble the preimplantation epiblast lineage. Whilst some of the signalling cascades that are fundamentally implicated ... -
The role of hypoxia in T cell function and immunotherapy
Oxygen deprivation (hypoxia) is an important immunosuppressive mechanism in cancer. The lack of proper blood supply and a high local metabolic demand depletes immune cells of key metabolites including oxygen. Tumour hypoxia ... -
Hypoxia, Lipid Signalling and Tissue Metabolism in Obesity-Related Metabolic Disease
There is a global epidemic of obesity and obesity-related metabolic disorders, such as metabolic syndrome and type-2 diabetes mellitus. While many factors contribute to the aetiology of these conditions, hypoxia is ... -
Structural and functional role of the extracellular loops and C-terminal domain of the voltage-gated sodium ion channel
Voltage-gated sodium ion channels (Nav) are central to action potential initiation through regulating the entry of sodium ions (Na+) into excitable cells including cardiomyocytes and neurones. The α-subunit of Nav consists ...
