Theses - Physiology, Development and Neuroscience
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Recent Submissions
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Mechanisms and dynamics of size regulation and lumen formation in mouse double embryos
Mouse embryogenesis is a paradigmatic example of regulative development, as embryos are able to compensate for alterations in the number of cells and to generate normal-sized pups. It was previously showed that double-sized ... -
Decoding the Notch signal: investigating dynamics of transcription directed by Notch responsive enhancers
Information from developmental signalling pathways must be accurately decoded to generate transcriptional outcomes. Notch is an evolutionarily conserved signalling pathway, which, despite its apparent simplicity, regulates ... -
Electronic implants with mechanically compliant coatings for interfacing with the nervous system
Interfacing with the nervous system holds immense therapeutic potential for the treatment of debilitating conditions such as nerve and spinal cord injury, and for restoring lost sensing modalities such as hearing or vision. ... -
Organ-specific heterogeneity in the endothelial cell hypoxia response
The aim of this thesis is to study the hypoxia response pathways within microvascular endothelial cells. In the first results chapter I investigated the differential role of the two hypoxia inducible transcription factors ...
