Theses - Physiology, Development and Neuroscience
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The mechanical regulation of Eph/ephrin signalling in the developing Xenopus brain
Eph receptors and their membrane-bound ligands, ephrins, provide key signals in many developmental processes including axon guidance. In the nervous system, concentration gradients of Ephs and ephrins are crucial in guiding ... -
Trophoblast specification and differentiation potential in early human and non-human primate embryogenesis
Implantation is mediated by trophoblast, the outer layer of the early embryo. Trophoblast is an extraembryonic tissue that gives rise to the placenta, which sustains fetal growth and development. Human embryo implantation ... -
The role of inherited determinants and embryonic-extraembryonic cell interactions in models of mammalian embryogenesis
Mammalian embryogenesis begins with the fusion of an oocyte and a sperm to create the first cell of the newly developing embryo called the zygote. The mechanisms by which this single cell generates a fully formed organism ... -
Pluripotency and patterning in nonhuman primate embryogenesis
Pluripotent cells of the embryo have the remarkable ability to form all somatic tissues and the germ line. Mice have long provided a framework for our understanding of this property of the early embryo. However, primate ...
