Theses - Physiology, Development and Neuroscience
About this collection
Recent Submissions
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Mechanical characterisation of rodent spinal cord tissue in health, trauma and disease
Spinal cord tissue is amongst the softest tissues in the body. Studying its mechanical properties is important as many cell types in the spinal cord react to their mechanical environment. Injury and disease can change ... -
Investigating the Role of Chemokines in Neutrophil Recruitment and Resolution During Inflammation
Neutrophils are innate immune cells and the first to be recruited to sites of injury, where they are essential for host defence. Defective neutrophil recruitment can inhibit pathogen clearance, while impaired neutrophil ... -
Defining the minimal and context-dependent signalling cascades regulating the maintenance of human naïve embryonic stem cells and early embryo development
Human naïve embryonic stem (HNES) cells can self-renew under defined culture conditions and closely resemble the preimplantation epiblast lineage. Whilst some of the signalling cascades that are fundamentally implicated ... -
The role of hypoxia in T cell function and immunotherapy
Oxygen deprivation (hypoxia) is an important immunosuppressive mechanism in cancer. The lack of proper blood supply and a high local metabolic demand depletes immune cells of key metabolites including oxygen. Tumour hypoxia ...
