Theses - Physiology, Development and Neuroscience
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Recent Submissions
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Organ-specific heterogeneity in the endothelial cell hypoxia response
The aim of this thesis is to study the hypoxia response pathways within microvascular endothelial cells. In the first results chapter I investigated the differential role of the two hypoxia inducible transcription factors ... -
Mechanisms behind the fate of early chromosomal and transcriptional heterogeneities in the mouse embryo
A series of events during the first four days of mouse embryo development leads to the formation of a blastocyst. The blastocyst consists of neatly segregated three lineages: the epiblast (EPI), which will form the fetus, ... -
The role of chemokine receptor trafficking in regulating neutrophil migration to inflammatory sites
(2020-05-16)Neutrophils are the first immune cells to be recruited to sites of tissue injury or infection. Upon detection of an inflammatory stimulus, neutrophils exit the vasculature and migrate directionally through the interstitial ... -
Understanding how neutrophils self-organise their migration to sites of inflammation in vivo
(2020-05-16)Neutrophils are major effectors of acute inflammation and microbial defence. Their infiltration and migration in injured tissue are critical for the inflammatory response. They are often observed navigating in a highly ...
