Department of Pharmacology
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G protein-coupled receptors (GPCRs) possess an inherent ability to bind to an extremely diverse range of ligands and activate multiple downstream signalling pathways. It is becomingly increasingly evident, however, that ...
(2022-02-26)Multidrug resistance (MDR) has been a significant problem for decades and limits the use of available chemotherapeutic drugs in treatments of bacterial infections and cancers. One of the key reasons for the development of ...
Stoichiometry of the interactions between endogenous Orai1 and STIM1 during store-operated Ca2+ entry Ca2+ is a ubiquitous intracellular messenger. It regulates a variety of cellular activities, ranging from muscle contraction, neuronal transmission, secretion and cell growth to apoptosis. Store-operated Ca2+ entry (SOCE) ...