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  • High-resolution optical analyses of IP3-evoked Ca2+ signals 

    Mataragka, Stefania (2019-07-19)
    Ca2+ is a universal intracellular messenger that regulates many cellular responses. Most cells express inositol 1,4,5-trisphosphate receptors (IP3R) that mediate Ca2+ release from the endoplasmic reticulum (ER) when they ...
  • Developing nanobodies to stabilise the tumour suppressor protein p16INK4a 

    Burbidge, Owen David (2019-03-23)
    The tumour suppressor protein p16INK4a (p16) is a cyclin-dependent kinase (CDK) inhibitor that plays a key role in the regulation of the cell cycle by controlling the progression of cells through the G1 to S phase transition. ...
  • On the Structure and Function of Multidrug Efflux Pumps 

    Neuberger, Arthur (2019-05-18)
    Infections arising from multidrug-resistant pathogenic bacteria are spreading rapidly throughout the world and threaten to become untreatable. The origins of resistance are numerous and complex, but one underlying factor ...
  • Ca2+ signalling between the endoplasmic reticulum and lysosomes 

    Atakpa, Peace (2019-01-09)
    Ca2+ is a universal and versatile intracellular messenger, regulating a vast array of biological processes due to variations in the frequency, amplitude, spatial and temporal dynamics of Ca2+ signals. Increases in cytosolic ...

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