Department of Pharmacology
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Visceral pain is a prominent cause of morbidity in gastrointestinal (GI) diseases, like inflammatory bowel disease (IBD) and irritable bowel syndrome (IBS), but many current analgesics produce GI side effects. To develop ...
Structure-based development of novel chemical scaffolds as inhibitors of the store-operated calcium entry pathway Calcium (Ca2+) is an intracellular messenger regulating various physiological activities. The ‘store-operated calcium entry’ (SOCE) is a significant, almost ubiquitous Ca2+ signaling pathway and is triggered when intracellular ...
The transcription factor Myc is expressed in cells in response to pro-growth signals and drives expression of a plethora of genes that promote proliferation. This pleiotropic activity renders loss of Myc regulation highly ...