Department of Pharmacology
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THE USE OF CATALYTICALLY DEAD CAS9 TO IDENTFY KEY TRANSCRIPTION REGULATORS IN TRIPLE NEGATIVE BREAST CANCER Triple-negative breast cancer (TNBC) accounts for approximately 15-20% of all breast cancer cases. It tends to be aggressive, high-grade and poorly differentiated tumour with poor clinical outcome. Lack of expression of ...
The ubiquitin-proteasome system (UPS) maintains homeostatic levels of proteins in normal cells and controls the levels of oncogenes and tumour suppressors by tagging proteins with ubiquitin for proteasomal degradation. The ...