Department of Clinical Neurosciences
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Multiple sclerosis associated SNPs influencing B cell expression of co-stimulatory receptors and T cell responses
(2020-01-27)Multiple sclerosis (MS) is an immune-mediated demyelinating disease of the central nervous system (CNS) which has a complex aetiology that involves the interplay of both genetic and environmental factors. Although more ... -
The neuroinflammatory basis of disease progression and cognitive impairment in Parkinson's disease
(2019-10-26)Parkinson’s disease (PD) is classically defined as a movement disorder, but a large proportion of patients also develop cognitive dysfunction as the disease progresses. Currently, it is not fully understood why some patients ... -
Investigation of the role of antagonism of the Interleukin-7 Receptor in the treatment of Multiple Sclerosis in Humans and In Vitro differences between genetically stratified subjects based on Interleukin-7 Receptor Genotype
(2020-04-25)Multiple Sclerosis is an autoimmune disease mediated by activated lymphocytes entering the central nervous system. Treatments with the greatest efficacy either prevent the entry of activated lymphocytes, or deplete the ... -
Investigating the effects of tau mutations in induced pluripotent stem cell-derived neurons
(2019-08-01)Microtubule-associated protein tau (MAPT) is a neuronal protein which promotes microtubule assembly and stabilisation. The MAPT gene is alternatively spliced to give six tau isoforms: three with 3 microtubule-binding repeats ...
