Department of Clinical Neurosciences
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Clinical frailty is independently associated with non-prescription of anticoagulants in older patients with atrial fibrillation
Aim Anticoagulants are underused in older patients with atrial fibrillation (AF). Scoring systems, such as CHA$_{2}$DS$_{2}$-VASc and HAS-BLED, are recommended to guide clinicians in anticoagulation decisions, but patients’ ... -
Inducible and Deterministic Forward Programming of Human Pluripotent Stem Cells into Neurons, Skeletal Myocytes, and Oligodendrocytes
The isolation or in vitro derivation of many human cell types remains challenging and inefficient. Direct conversion of human pluripotent stem cells (hPSCs) by forced expression of transcription factors provides a potential ... -
A non-cell autonomous mouse model of CNS haemangioblastoma mediated by mutant KRAS
(Nature Publishing Group, 2017-03-21)Haemangioblastoma is a rare malignancy of the CNS where vascular proliferation causes lesions due to endothelial propagation. We found that conditionally expressing mutant Kras, using Rag1-Cre, gave rise to CNS haemangioblastoma ... -
Functional connectivity in amygdalar-sensory/(pre)motor networks at rest: new evidence from the Human Connectome Project
(Wiley, 2017-05-01)The word 'e-motion' derives from the Latin word 'ex-moveo' which literally means 'moving away from something/somebody'. Emotions are thus fundamental to prime action and goal-directed behavior with obvious implications for ...
