Department of Clinical Neurosciences
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Investigating the effects of tau mutations in induced pluripotent stem cell-derived neurons
(2019-08-01)Microtubule-associated protein tau (MAPT) is a neuronal protein which promotes microtubule assembly and stabilisation. The MAPT gene is alternatively spliced to give six tau isoforms: three with 3 microtubule-binding repeats ... -
Imaging Myelin Basic Protein expression in a model of remyelination by Magnetic Resonance Imaging using an Organic Anion Transporter Protein gene reporter system.
Demyelination occurs in several CNS diseases. If demyelinated axons are not remyelinated they become vulnerable to irreversible degeneration. There is, therefore, a clinical need for therapies that enhance remyelination. ... -
Gene therapy for axon regeneration
(2019-10-26)Injury to the brain and spinal cord has devastating consequences because adult neurons in the central nervous system (CNS) do not regenerate. Traumatic CNS injuries are a significant clinical problem and have life-changing ...
