Department of Clinical Neurosciences
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Reduced number of axonal mitochondria and tau hypophosphorylation in mouse P301L tau knockin neurons.
(2015-10-11)Expression of the frontotemporal dementia-related tau mutation, P301L, at physiological levels in adult mouse brain (KI-P301L mice) results in overt hypophosphorylation of tau and age-dependent alterations in axonal ... -
Mislocalization of neuronal tau in the absence of tangle pathology in phosphomutant tau knockin mice.
(201512-07)Hyperphosphorylation and fibrillar aggregation of the microtubule-associated protein tau are key features of Alzheimer's disease and other tauopathies. To investigate the involvement of tau phosphorylation in the pathological ... -
Alemtuzumab as Treatment for Multiple Sclerosis.
(2018-03-02)Alemtuzumab, the first monoclonal antibody to be used as a therapy and the first to be humanized, was introduced into the treatment of multiple sclerosis in 1991 after its successful use in hematology, oncology, and ...
