Department of Clinical Neurosciences
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Evaluating Magnetic Resonance Imaging and Serum Markers As Surrogate Endpoints for Clinical Trials in Cerebral Small Vessel Disease
Cerebral small vessel disease (SVD) causes a quarter of all strokes and is the most common pathology underlying vascular cognitive impairment and dementia. White matter hyperintensities, lacunar infarcts, cerebral microbleeds ... -
Cellular Phenotypes Associated with NRXN1 Mutations in Autism; an iPSC Study
Autism spectrum conditions are neurodevelopmental conditions that entail social- communication difficulties, unusually narrow interests and difficulties adjusting to unexpected change. While the role of NRXN1 has been ... -
Establishment of a Novel Patient hiPSC-derived in vitro Blood-Brain Barrier Model of Collagen IV Small Vessel Disease
Cerebral small vessel disease (SVD) is a prevalent cause of stroke (25-30%) and dementia (45%). Despite its frequency, little is known about the cause and disease progression of SVD. Matrisome alteration leading to blood-brain ... -
In vivo pathology markers in tauopathies: prognostic and diagnostic implications
The neurodegenerative tauopathies include Alzheimer’s disease, frontotemporal dementia (half due to tauopathy), and progressive supranuclear palsy (PSP). In addition to abnormal accumulation of tau protein, they are each ...
