Department of Clinical Neurosciences
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In recent years, evidence of white matter involvement in patients with mitochondrial disorders has been increasing. Given the high-energy demand nature of the brain, this tissue is preferentially affected by energy deficiency ...
Understanding and ameliorating perturbations of human cerebral energy metabolism after major trauma (2021-05-01)After sustaining a severe traumatic brain injury (TBI) dysfunction of cerebral energy metabolism can cause further injury to the traumatised brain – resulting in worse patient morbidity, or death. Using the modalities of ...
Evaluating Magnetic Resonance Imaging and Serum Markers As Surrogate Endpoints for Clinical Trials in Cerebral Small Vessel Disease Cerebral small vessel disease (SVD) causes a quarter of all strokes and is the most common pathology underlying vascular cognitive impairment and dementia. White matter hyperintensities, lacunar infarcts, cerebral microbleeds ...