Department of Clinical Neurosciences
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In vivo pathology markers in tauopathies: prognostic and diagnostic implications
The neurodegenerative tauopathies include Alzheimer’s disease, frontotemporal dementia (half due to tauopathy), and progressive supranuclear palsy (PSP). In addition to abnormal accumulation of tau protein, they are each ... -
Integrative genomic analysis of Neurogenin2 reprogramming of human iPSCs
Direct cell reprogramming is a rapidly growing field that has challenged traditional concepts of cellular identity. The expression of Neurogenin 2 (NGN2) results in rapid reprogramming of human pluripotent stem cells (PSCs) ... -
Mechanisms of apathy in health and Parkinson's disease
Apathy and impulsivity are common and debilitating consequences of many neuropsychiatric diseases, including Parkinson's disease. Despite their prevalence and prognostic importance, their underlying mechanisms remain poorly ... -
Exploring SARM1 as a target to delay programmed axon degeneration
Programmed axon degeneration (Wallerian degeneration) can occur after physical injury, inhibition of axon transport, exposure to neurotoxic compounds, and in diseases involving mitochondrial or metabolic dysfunction. There ...
