Theses - Clinical Neurosciences
About this collection
Recent Submissions
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Promoting and measuring remyelination and neuroprotection in clinical trials of people with multiple sclerosis
The most tractable strategy to delay or prevent the progressive phase of MS is to promote endogenous remyelination; doing so restores nerve conduction and prevents demyelinated axons from degenerating. The rate-limiting ... -
The cognitive function of the DMN and its role in consciousness
(2021-09-23)Background: Whatever mental states one is experiencing, the brain is constantly active and demonstrates surprisingly regular spatial patterns, which are characterised by the presence of intrinsic functional connectivity ... -
Investigation of the ABI3 protein in microglia and its association with Alzheimer’s disease in TgCRND8 mouse model
Recent genome wide-association studies (GWAS) have identified several disease-related genetic variants among Alzheimer’s disease (AD) patients. A cluster of these genes, including TREM2, PLCG2 and ABI3, are highly expressed ... -
Autoantibody Responses to Traumatic Brain Injury
Traumatic brain injury (TBI) is the leading cause of death and disability in young adults in the developed world. After accounting for known prognostic factors, there remains marked unexplained heterogeneity in outcome ...
