Theses - Clinical Neurosciences
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Recent Submissions
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Development of PET Radiotracers for Imaging Neurodegeneration: Targeting alpha-Synuclein Fibrils and TSPO
(2019-01-25)Positron emission tomography (PET) is a non-invasive medical imaging technique that allows visualisation and quantification of biochemical, physiological and pharmacological processes in living subjects. This is achieved ... -
The role of germline and somatic nuclear and mitochondrial DNA variation in neurodegenerative disorders
Neurodegenerative disorders are a group of age-related conditions resulting in neuronal cell death and protein accumulation. It is estimated that around 5-10% of these cases are genetically mediated. Most commonly this is ... -
CNS Remyelination and the Gut Microbiota
(2018-10-20)Remyelination describes the regeneration of myelin sheaths, and is considered one of the most promising strategies for improving the prognosis of demyelinating diseases such as multiple sclerosis. Data from animal models ... -
Neural stem cells respond to extracellular succinate via SUCNR1/GPR91 to ameliorate chronic neuroinflammation
(2018-07-20)Neural stem cell (NSC) transplantation induces recovery in animal models of central nervous system (CNS) diseases, in part by modulating adaptive and innate immune responses. Since metabolism governs the phenotype and ...
