Theses - Clinical Neurosciences
About this collection
Recent Submissions
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Cellular Phenotypes Associated with NRXN1 Mutations in Autism; an iPSC Study
Autism spectrum conditions are neurodevelopmental conditions that entail social- communication difficulties, unusually narrow interests and difficulties adjusting to unexpected change. While the role of NRXN1 has been ... -
Establishment of a Novel Patient hiPSC-derived in vitro Blood-Brain Barrier Model of Collagen IV Small Vessel Disease
Cerebral small vessel disease (SVD) is a prevalent cause of stroke (25-30%) and dementia (45%). Despite its frequency, little is known about the cause and disease progression of SVD. Matrisome alteration leading to blood-brain ... -
In vivo pathology markers in tauopathies: prognostic and diagnostic implications
The neurodegenerative tauopathies include Alzheimer’s disease, frontotemporal dementia (half due to tauopathy), and progressive supranuclear palsy (PSP). In addition to abnormal accumulation of tau protein, they are each ... -
Integrative genomic analysis of Neurogenin2 reprogramming of human iPSCs
Direct cell reprogramming is a rapidly growing field that has challenged traditional concepts of cellular identity. The expression of Neurogenin 2 (NGN2) results in rapid reprogramming of human pluripotent stem cells (PSCs) ...
