Theses - Clinical Neurosciences
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Virtual reality navigation assessment and 7 tesla MR imaging of the entorhinal-hippocampal circuit in asymptomatic at-risk Alzheimer's disease Identification of the initial alterations of brain function in Alzheimer’s disease (AD) is critically important for early disease detection and future use of disease-modifying drugs to delay progression to dementia. Given ...
Traumatic Injury-Induced Cell Responses in Human Cortical Organoids Traumatic brain injury (TBI) impacts millions of individuals worldwide each year, which often leads to permanent disabilities and emerges as an important risk factor for neurodegenerative diseases. This is driven by secondary ...
Origin and Role of Nuclear Somatic Mutations in Frontotemporal Dementia Ageing is a natural process that occurs in all cells of multicellular organisms, including non-dividing cells like neurons, and is associated with the accumulation of mutational burden and a loss of genomic maintenance ...