Theses - Clinical Neurosciences
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Recent Submissions
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Mitochondrial metabolism and CNS myelination
In recent years, evidence of white matter involvement in patients with mitochondrial disorders has been increasing. Given the high-energy demand nature of the brain, this tissue is preferentially affected by energy deficiency ... -
Understanding and ameliorating perturbations of human cerebral energy metabolism after major trauma
(2021-05-01)After sustaining a severe traumatic brain injury (TBI) dysfunction of cerebral energy metabolism can cause further injury to the traumatised brain – resulting in worse patient morbidity, or death. Using the modalities of ... -
Evaluating Magnetic Resonance Imaging and Serum Markers As Surrogate Endpoints for Clinical Trials in Cerebral Small Vessel Disease
Cerebral small vessel disease (SVD) causes a quarter of all strokes and is the most common pathology underlying vascular cognitive impairment and dementia. White matter hyperintensities, lacunar infarcts, cerebral microbleeds ... -
Cellular Phenotypes Associated with NRXN1 Mutations in Autism; an iPSC Study
Autism spectrum conditions are neurodevelopmental conditions that entail social- communication difficulties, unusually narrow interests and difficulties adjusting to unexpected change. While the role of NRXN1 has been ...
