Theses - Clinical Neurosciences
About this collection
Recent Submissions
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Interrogating and potentiating energy metabolism in the human brain after traumatic brain injury
(2018-04-02)The pathophysiology of traumatic brain injury (TBI) includes perturbations to energy metabolism. Improving our understanding of cerebral energy metabolism will lead to strategies that improve clinical outcomes. For the ... -
Exploring the methylome and transcriptome of young adult and aged OPCs
Remyelination is the restoration of myelin sheaths to denuded axons following demyelinating events, which occurs spontaneously in adult mammals, including humans. The principal cells which participate in remyelination are ... -
Intracranial Monitoring after Severe Traumatic Brain Injury
(2018-11-25)Intracranial monitoring after severe traumatic brain injury offers the possibility for early detection and amelioration of physiological insults. In this thesis, I explore cerebral insults due raised intracranial pressure, ... -
Defining the cellular and molecular mechanism of maternally inherited hearing loss
(2018-01-11)Mitochondrial dysfunction causes moderate to profound hearing loss both in isolation and as a feature of multi-systemic mitochondrial disease. The m.1555A>G mitochondrial DNA (mtDNA) variant is associated with a predisposition ...
