Theses - Clinical Neurosciences
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Regulation of oligodendrocyte lineage cell function by the RXRγ nuclear receptor
(2019-05-18)Remyelination is a spontaneous regenerative process whereby myelin sheaths are restored to demyelinated axons. Key players in this process are oligodendrocyte progenitor cells (OPCs), a widespread population of CNS progenitor ... -
Actions of alpha-chimaerins in mechanisms relevant to dendritic spine formation and neurodegeneration
(2019-01-26)Rho GTPases and their regulators such as guanosine exchange factors (GEFs) and GTPase activating proteins (GAPs) represent an important class of molecules controlling dendritic spine plasticity. Although they are typically ... -
Characterising Heterogeneity of Glioblastoma using Multi-parametric Magnetic Resonance Imaging
(2018-12-06)A better understanding of tumour heterogeneity is central for accurate diagnosis, targeted therapy and personalised treatment of glioblastoma patients. This thesis aims to investigate whether pre-operative multi-parametric ... -
Modifications of perineuronal nets to regulate plasticity
(2019-07-01)Modifications of perineuronal nets to regulate plasticity Heleen Merel van ‘t Spijker Perineuronal nets (PNNs) are macromolecular structures formed by neurons after closure of critical periods of plasticity. During ...
