Wellcome Sanger Institute
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Normal cell signals in human cancer transcriptomes
Cancer cells arise from normal cells, and may retain transcriptional patterns present in the cell of origin. Recent advances in single-cell transcriptomics have allowed us to profile both normal and cancer cells at a single ... -
Exploring the Population Structure, Recombination Landscape, and Pan-Genome of the Global Neisseria meningitidis Population
Neisseria meningitidis is a gram-negative species of bacteria which causes meningitis, septicaemia, urethritis, and pneumonia worldwide. Infections are typically asymptomatic carriage, but those which cause disease are ... -
Comparative and population genomic analyses of the parasitic blood flukes
The etiological agents of schistosomiasis are snail-vectored, waterborne, parasitic trematodes of the genus Schistosoma. Schistosomes are considered a considerable public health concern responsible for infecting over 236 ... -
Somatic mutagenesis in humans with deficient DNA repair
The accumulation of mutations in normal cells causes the development of cancer and is implicated as a potential mechanism in the physiological process of ageing. In recent years our ability to interrogate the genome of ...
