Sanger Institute
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Graphical pangenomics
(2019-10-26)Completely sequencing genomes is expensive, and to save costs we often analyze new genomic data in the context of a reference genome. This approach distorts our image of the inferred genome, an effect which we describe as ... -
Genetic dissection of EGFRvIII brain and spinal mouse gliomas through whole-exome sequencing and in vivo piggyBac mutagenesis forward genetic screening
(2019-07-19)Glioma is the commonest intrinsic brain tumor, and its high-grade form has a devastating prognosis. These tumors also arise in the spinal cord, carrying significant morbidity in children; however the genetics of these ... -
Identifying regulators of cytotoxic T cell function through molecular and genetic screening
(2019-07-19)Cytotoxic T lymphocytes (CTL) are crucial components of the adaptive immune system that kill infected and tumourigenic cells. CTL killing requires focused secretion of cytotoxic compounds from lytic granules. This process ... -
Pleiotropy in complex traits
(2019-06-30)Genome-wide association studies (GWAS) have uncovered thousands of complex trait loci, many of which are associated with multiple phenotypes. The dedicated study of these pleiotropic effects is becoming increasingly common ...
