Sanger Institute
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Characterising the gene regulatory landscape of CD4+ T cells
(2019-10-05)Despite the high prevalence of immune-mediated diseases, the molecular mechanisms by which they arise and the influence of genetic variation in the predisposition to disease are not well understood. Immune susceptibility ... -
Comparative and Epidemiological Genomics of Human Malaria Parasites
Following both significant advances and setbacks in the past decades of fighting malaria, the end goal of malaria elimination is now once again within sight. However, this endgame may prove the most challenging yet, as ... -
Using genetic and genomic approaches to understand haematopoietic cellular biology and dysregulation in disease
(2019-07-19)Genetic and genomic approaches have revolutionised the way we address disease aetiology, potential treatment and methods to understand fundamental biology. Many different approaches can be applied to attempt to resolve the ... -
Extracellular Interaction Screening Using CRISPR Activation
(2019-11-30)Extracellular interactions between cell surface receptors are necessary for signaling and adhesion but identifying them remains technically challenging. We describe a cell-based genome-wide approach employing CRISPR ...
