Sanger Institute
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Lineage tracing of normal human development and childhood cancers
From fertilisation onwards, the cells of the human body continuously experience damage to their genome, either from intrinsic causes or from exposure to mutagens. While the vast majority of DNA damage is repaired and the ... -
The molecular landscape of cutaneous melanoma and its clinical implications
Cutaneous melanoma arises due to the uncontrolled proliferation of melanocytes. It is the deadliest form of skin cancer and its incidence, particularly in younger adults, is rapidly rising worldwide. Over the past decade, ... -
Insights into the genomic histories of diverse human populations using whole-genome sequencing analysis.
Despite the progress in sampling many populations, human genomics research is still not fully reflective of the diversity found globally. Understudied populations limit our knowledge of genetic variation and population ... -
Modelling human complex traits with regression and neural-network based methods
(2021-06-23)Identifying how epistasis, non-linear genetic effects, contribute to phenotypic variance in humans has been an enduring challenge. So far neither the computational resources that could accommodate higher-order interactions ...
