Sanger Institute
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Understanding Developmental Decision Making in Malaria Parasites using Single-Cell Transcriptomics
Single-cell sequencing has the potential to revolutionise our understanding of malaria parasites. Malaria is caused by single-celled parasitic organisms of the genus Plasmodium which display remarkable cellular plasticity ... -
Genomic profiling of response to $\textit{in vivo}$ immune perturbations
The human immune system plays a central role in defense against infection, but its dysregulation is implicated in immune-mediated diseases. The past decade has seen increasing application of high-throughput technologies ... -
Computational analyses of non-canonical architectural and structural features associated with alternative splicing
Splicing of nuclear introns is catalysed by the spliceosome, one of the most complex macromolecular machines currently known. Even though the canonical splicing signals that drive the precise recognition of splice sites ... -
Somatic Mutations in Primary Sjögren’s Syndrome
Somatic Mutations in Primary Sjögren’s Syndrome Aleksandra Ivovic Despite decades of research and many insightful findings, a complete understanding of the pathogenesis of autoimmune diseases continues to elude us. In this ...
