Wellcome Sanger Institute
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Characterisation of Plasmodium parasite sexual commitment and development
Malaria is a devastating disease responsible for over 400,000 deaths each year. The disease is caused by a single-celled parasite of the genus Plasmodium, which establishes infection via a bite from an Anopheline mosquito. ... -
Reconstructing Chromothriptic Chromosomes in Oesophageal Adenocarcinomas
The epigenetic landscape is regulated by a myriad of factors. This regulation ranges from functional compartmentalisation of genomic sequences into topologically associating domains, to chromosome looping, to short-range ... -
Somatic evolution in healthy and chronically inflamed colon and skin
The human body is made up of trillions of cells which cooperate to reproduce their genetic material. While all the cells are a part of a whole, each is also an individual and will selfishly give rise to a clonal expansion ... -
Human intestinal cells across space and time
(2022-01-17)Cells of the human intestinal tract undergo dynamic changes from development to adulthood and in response to environmental stimuli. Recent advances in high-throughput profiling of cells using transcriptomic approaches have ...
