Theses - Sanger Institute
About this collection
Recent Submissions
-
The Intra-Tumour Heterogeneity Landscape of Human Cancers
(2020-01-10)Tumours accumulate many somatic mutations in their lifetime. Some of these mutations, drivers, convey a selective advantage and can induce clonal expansions. Incomplete clonal expansions give rise to intra-tumour heterogeneity. ... -
Dynamics of the human gut microbiota in very early life
(2020-05-16)Immediately after birth, newborn babies experience rapid colonisation by microorganisms from their mothers and the surrounding environment. Diseases in childhood and later in life are potentially mediated through perturbation ... -
The Cell-Essentiality of KAT7 in Acute Myeloid Leukemia
(2020-01-01)Acute myeloid leukemia (AML) is an aggressive hematopoietic malignancy, characterized by the uncontrolled proliferation and differentiation arrest of myeloid progenitors. Chemotherapy has been the front-line treatment for ... -
Human Cellular Genetics of Innate Immunity
(2020-01-25)The type I interferon response is a key part of the innate immune system, responding to infection and inducing an antiviral intracellular state. While there is known to be variability in this signalling pathway between ...
