Theses - Sanger Institute
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Genome-wide search for regulators of the first cell lineage decision in the mouse: a CRISPR/Cas9 endeavour
In vitro cell lines derived from the early embryo retain the identity and lineage restrictions of their embryonic counterparts: embryonic stem cells (ESCs) are pluripotent and similarly to ICM contribute to all tissues in ... -
The Transcriptional Profile of Microglia: From Brain to Dish
The Transcriptional Profile of Microglia: from Brain to Dish Fiona Elizabeth Calvert Microglia are the tissue resident macrophages of the central nervous system (CNS) and multiple lines of evidence indicate that microglia ... -
INDUCED PLURIPOTENT STEM CELL DERIVED LIVER MODEL FOR THE STUDY OF PNPLA3-ASSOCIATED NON-ALCOHOLIC FATTY LIVER DISEASE
Non-alcoholic fatty liver disease (NAFLD) is now the leading cause of chronic liver disease in the developed world, afflicting approximately one in four adults globally. NAFLD is defined by the accumulation of fat within ... -
Germline mutation in rare disease
Germline mutation is the ultimate source of evolutionary change and disease-causing variants. Understanding the rates and patterns of human mutation can help us learn about their molecular origins, uncover our evolutionary ...
