Theses - Sanger Institute
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Recent Submissions
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The use of human pluripotent stem cells to model HNF1B-associated diabetes
(2018-11-24)Heterozygous mutations in the transcription factor, hepatocyte nuclear factor 1B (HNF1B), result in multisystem disease including diabetes due to beta-cell dysfunction and pancreatic hypoplasia. However, the mechanisms ... -
Transcriptome characterisation of the intra-mammalian stage of male and female Schistosoma mansoni
(2018-12-15)Schistosoma mansoni is a member of a genus of platyhelminths whose members cause the disease schistosomiasis. Particularly prevalent in sub-Saharan Africa, it is thought to be directly responsible for approximately 5500 ... -
Molecular evolution of biological sequences
(2018-10-20)Evolution is an ubiquitous feature of living systems. The genetic composition of a population changes in response to the primary evolutionary forces: mutation, selection and genetic drift. Organisms undergoing rapid ... -
Functional analyses of the canine antigen receptor loci
(2018-10-20)
