Theses - Sanger Institute
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Pseudomonas aeruginosa genetics and virulence in cystic fibrosis and bacteraemia
Pseudomonas aeruginosa is an opportunistic pathogen that can invade and colonise the lungs of people with cystic fibrosis (CF), cause septic shock through bacteraemia infections, and lead to serious infection of burn ... -
Immunity Against Malaria: an Atlas of the Mosquito Cellular Immune System at Single Cell Resolution
(2020-09-01)Malaria is a deadly, worldwide disease, yearly responsible for 219 million cases and over four hundred thousand deaths. The Anopheles gambiae species complex is the main African vector for the most virulent malaria parasite: ... -
The Genetics of IBD: From Susceptibility to Drug Response and Patient Outcome
(2020-07-17)Inflammatory bowel disease (IBD) is a group of immune-mediated autoinflammatory disorders, primarily manifesting in the gastrointestinal tract. Affecting millions of people around the world, IBD has a severe impact on ... -
Genetic alterations defining human primary melanoma and mechanisms of immune evasion
(2020-04-25)The somatic mutations found in melanomas reflect the biological processes that govern tumour development. They also help shape how tumours evolve and escape immune regulation. Studying these changes can therefore help to ...
