About this collection

Recent Submissions

  • The Intra-Tumour Heterogeneity Landscape of Human Cancers 

    Dentro, Stefan Christiaan (2020-01-10)
    Tumours accumulate many somatic mutations in their lifetime. Some of these mutations, drivers, convey a selective advantage and can induce clonal expansions. Incomplete clonal expansions give rise to intra-tumour heterogeneity. ...
  • Dynamics of the human gut microbiota in very early life 

    Shao, Yan (2020-05-16)
    Immediately after birth, newborn babies experience rapid colonisation by microorganisms from their mothers and the surrounding environment. Diseases in childhood and later in life are potentially mediated through perturbation ...
  • The Cell-Essentiality of KAT7 in Acute Myeloid Leukemia 

    Au, Yan Zi (2020-01-01)
    Acute myeloid leukemia (AML) is an aggressive hematopoietic malignancy, characterized by the uncontrolled proliferation and differentiation arrest of myeloid progenitors. Chemotherapy has been the front-line treatment for ...
  • Human Cellular Genetics of Innate Immunity 

    Rostom, Raghd (2020-01-25)
    The type I interferon response is a key part of the innate immune system, responding to infection and inducing an antiviral intracellular state. While there is known to be variability in this signalling pathway between ...

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