Theses - Sanger Institute
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Recent Submissions
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Genetic studies of cardiometabolic traits
(2019-07-19)Diet and lifestyle have changed dramatically in the last few decades, leading to an increase in prevalence of obesity, defined as a body mass index >30Kg/m2, dyslipidaemias (defined as abnormal lipid profiles) and type 2 ... -
New approaches for measuring fitness of Plasmodium falciparum mutations implicated in drug resistance
(2019-07-20)The repeated emergence of drug resistance in Plasmodium falciparum underscores the importance of understanding the genetic architecture of current resistance pathways, as well as any associated fitness costs. Why resistance ... -
Applying animal modelling to understand rare novel neurodevelopmental disorders associated with intellectual disability
(2019-01-26)Intellectual disability (ID) is categorised by a significant reduction in cognitive function and adaptive abilities that begin in childhood. ID is part of a heterogeneous group of neurodevelopmental conditions associated ... -
The use of human pluripotent stem cells to model HNF1B-associated diabetes
(2018-11-24)Heterozygous mutations in the transcription factor, hepatocyte nuclear factor 1B (HNF1B), result in multisystem disease including diabetes due to beta-cell dysfunction and pancreatic hypoplasia. However, the mechanisms ...
