Theses - Sanger Instititute
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Genomic insights into the human population history of Australia and New Guinea
(2018-07-20)The ancient continent of Sahul, encompassing Australia, New Guinea and Tasmania, contains some of the earliest archaeological evidence for humans outside of Africa, dating back to at least 50 thousand years ago (kya). New ... -
The role of transcription factor GATA6 in the development of the human pancreas
(2018-02-07)While there has been an opulence of data and studies surrounding the study of the developing pancreas in mammals and other vertebrates, the focus has largely been in mice. The paucity of research in the development of the ... -
Genome-scale identification of cellular pathways required for cell surface recognition
(2018-04-28)A range of biochemically diverse molecules located in the plasma membrane— such as proteins, glycans, and lipids—mediate cellular recognition events, initiation of signalling pathways, and the regulation of processes ... -
Using molecular QTLs to identify cell types and causal variants for complex traits
(2018-01-09)Genetic associations have been discovered for many human complex traits, and yet for most associated loci the causal variants and molecular mechanisms remain unknown. Studies mapping quantitative trait loci (QTLs) for ...
