Department of Genetics
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Testing roles of Hereditary Spastic Paraplegia genes in axonal endoplasmic reticulum modelling in Drosophila
(2021-03-27)Hereditary spastic paraplegias (HSPs) are neurodegenerative disorders characterized by progressive lower limb spasticity due to axonal degeneration. Smooth endoplasmic reticulum (ER) forms a longitudinal network within the ... -
Consequences of Plk4 overexpression in mouse pancreatic organoids
Overexpression of the polo-like kinase 4 (Plk4), the master regulator of centrosome duplication, leads to centrosome amplification, a common feature of cancer, including pancreatic cancer. Previous studies have shown that ... -
Spatiotemporal control of gene expression in Caenorhabditis elegans
(2020-09-29)Cell-type specific regulation of transcription drives the production of the myriad of different cells generated during development. Profiling genome-wide gene expression landscapes in different tissues has improved our ...
