Department of Genetics
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Ribonucleic acid (RNA) is a biological molecule that exists in the cell of virtually all kinds of known living organisms. Although its significance in fundamental cellular processes such as protein synthesis has been known ...
We know little about how isoform choice is regulated in individual cells for most spliced genes. In theory, single-cell RNA-sequencing (scRNA-seq) could enable us to investigate isoform choice at cellular resolution. ...
(2020-05-16)In this thesis, I explore variation-aware algorithms for analyzing cancer genomes. The scientific community has extensively catalogued millions of mutations present in cancer cells. This information is rarely used during ...