Department of Genetics
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Complex Coding and Regulatory Polymorphisms in a Restriction Factor Determine the Susceptibility of Drosophila to Viral Infection
It is common to find that major-effect genes are an important cause of variation in susceptibility to infection. Here we have characterised natural variation in a gene called pastrel that explains over half of the genetic ... -
The Centrioles, Centrosomes, Basal Bodies, and Cilia of Drosophila melanogaster.
(Genetics Society of America, 2017-05)Centrioles play a key role in the development of the fly. They are needed for the correct formation of centrosomes, the organelles at the poles of the spindle that can persist as microtubule organizing centers (MTOCs) into ... -
$\textit{Mycobacterium tuberculosis}$ resistance prediction and lineage classification from genome sequencing: comparison of automated analysis tools
(Nature Publishing Group, 2017-04-20)Whole-genome sequencing (WGS) has the potential to accelerate drug-susceptibility testing (DST) to design appropriate regimens for drug-resistant tuberculosis (TB). Several recently developed automated software tools promise ... -
Inference of Candidate Germline Mutator Loci in Humans from Genome-Wide Haplotype Data
(Public Library of Science (PLoS), 2017-01)The rate of germline mutation varies widely between species but little is known about the extent of variation in the germline mutation rate between individuals of the same species. Here we demonstrate that an allele that ...
