Department of Genetics
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Investigating the Regulation of Mitochondrial DNA Dynamics with a Drosophila Model
The maternally inherited mitochondrial DNA (mtDNA) is a multi-copy genome that encodes several mitochondrial proteins essential for energy production. Heteroplasmy, the state of possessing multiple variants of mtDNA, is ... -
Transposable Elements and the Evolution of Virus Resistance in Drosophila melanogaster
Viral infection results in a significant fitness cost on organisms, which driving evolutionary change in antiviral defences. Previous research in Drosophila has shown that there is large genetic variation in pathogen ... -
Pattern Formation During Extensive Cell Movements
As embryos develop, they are required to generate organised patterns of gene expression across developing tissues. Previous hypotheses used to explain how patterns form in developing tissues have relied on the ideas of ... -
Assessing the transition state model for cellular differentiation in vivo: a case study of zebrafish neuromesodermal progenitors
During the process of cellular differentiation, stem or progenitor cells undergo a sequence of cell state changes before acquiring the characteristics of their destination fate. The transition state model proposes that a ...
