Department of Genetics
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The role of non-genetic variability in Acute Myeloid Leukaemia
Acute myeloid leukaemia (AML) is a heterogeneous clonal disorder of haematopoietic progenitor cells with a dismal survival. It has a strong reliance on epigenetic and transcriptional factors for disease progression. ... -
The evolution of somitogenesis: Mechanisms of paraxial mesoderm elongation in zebrafish and other vertebrates
In vertebrate embryos, a process called somitogenesis lays the foundations of the adult spine. This process involves elongation and segmentation of the paraxial mesoderm to form somites. Although the segmentation aspect ... -
Testing roles of Hereditary Spastic Paraplegia genes in axonal endoplasmic reticulum modelling in Drosophila
(2021-03-27)Hereditary spastic paraplegias (HSPs) are neurodegenerative disorders characterized by progressive lower limb spasticity due to axonal degeneration. Smooth endoplasmic reticulum (ER) forms a longitudinal network within the ... -
Consequences of Plk4 overexpression in mouse pancreatic organoids
Overexpression of the polo-like kinase 4 (Plk4), the master regulator of centrosome duplication, leads to centrosome amplification, a common feature of cancer, including pancreatic cancer. Previous studies have shown that ...
