Department of Genetics
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Genetic interactors of the SWI/SNF chromatin remodelling complex in Caenorhabditis elegans
Chromatin remodellers are adenosine triphosphate (ATP)-powered molecular machines that can directly alter the structure of chromatin by reshuffling or evicting nucleosomes. Thereby they control the access to DNA elements ... -
Cell cycle control governing built-in asymmetry underlying the spindle pole body duplication cycle in Saccharomyces cerevisiae
Self-renewing stem cell divisions typically couple the polarised orientation of the mitotic spindle with an invariant age-dependent pattern of centrosome inheritance. Self- renewal supports tissue homeostasis by providing, ... -
Modelling Embryonic Haematopoiesis Using In Vitro State-of-art Gastruloid Culture
Haematopoietic stem cell progenitor cells (HSPCs) have substantial research and therapeutic value, but the in vitro production of HSPCs from pluripotent stem cells remains elusive. A novel 3D culture method, known as a ... -
The evolution and genetics of virus resistance in Drosophila
Parasites impose high selection pressure on host fitness and are thought to be a major selective factor that promotes the evolution of resistance in host populations. Much of the resistance is determined by genetic factors, ...
