Department of Genetics
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Investigating 3D genome organisation in Caenorhabditis elegans with Accessible Region Conformation Capture (ARC-C)
(2019-07-20)3C and its derivatives have been applied in various organisms to study chromatin architecture. However, these methods have limitations: most of them are limited to restriction-fragment resolution and all of them, with the ... -
Comparative functional analysis of the atypical Notch ligands DLK1 and DLK2 in vertebrate development
(2019-07-12)DLK1 and DLK2 are vertebrate specific non-canonical Notch ligands. Dlk1 is imprinted throughout murine development [76] but selectively loses its imprint in the postnatal neurogenic niche by an unknown mechanism [78]. ... -
The Contribution of Retrotransposons to the Transcriptomes of Murine Somatic Cells
(2019-10-26)Retrotransposons comprise approximately 40% of the mouse genome. Once thought to be useless “junk” DNA, there is growing evidence that retrotransposons play crucial roles in genome evolution and gene regulation, and ... -
Visualizing Roles of Spastic Paraplegia Proteins in Organizing Axonal ER in Live Drosophila
(2019-07-19)Axons possess a continuous network of smooth tubular endoplasmic reticulum (ER), extending from the nuclear envelope throughout the neuron to synapses. Mutations affecting proteins with intramembrane hairpin domains that ...
