Theses - Genetics
About this collection
Recent Submissions
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Ancestral Paths: Redefining local genetic ancestry and its inference with application to Europeans
Recently, two new approaches have transformed our understanding of human population history. Firstly, the sequencing of ancient genomes which gives us a snapshot of past genetic variation. We can therefore make inferences ... -
The Evolution of Drosophila Immunity
The ubiquity of pathogens in the natural world poses a strong selection force on the evolution of Drosophila immunity. Under the pressure of this natural selection by pathogenic organisms, species diverge along the ... -
Identification and characterisation of KZFPs directly regulated by p53
Approximately 50% of human DNA is composed of transposable elements (TEs), which in subsequent waves colonized our genome across evolutionary history. KRAB zinc finger proteins (KZFPs) are the largest group of DNA binding ... -
Genetic interactors of the SWI/SNF chromatin remodelling complex in Caenorhabditis elegans
Chromatin remodellers are adenosine triphosphate (ATP)-powered molecular machines that can directly alter the structure of chromatin by reshuffling or evicting nucleosomes. Thereby they control the access to DNA elements ...
