Theses - Surgery
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Role of the cell cycle during human endothelial-to-haematopoietic transition
(2019-04-27)Haematopoietic stem cells (HSC) are responsible for the maintenance of blood homeostasis and are of fundamental importance for the treatment of a variety of life-threatening diseases. However, their scarce availability ... -
Production of hepatocytes from human pluripotent stem cells for cell-based therapy
(2019-07-20)Human pluripotent stem cells (hPSCs) can self-renew indefinitely in vitro while maintaining the capacity to differentiate into diverse cell types, including hepatocytes. Thus, hPSCs allow for large-scale production of ... -
Humoral alloimmunity in cardiac allograft rejection
(2019-04-27)Although the short-term outcomes of solid allograft survival have improved substantially over the last few decades, there has been no significant improvement in long-term survival of solid allografts. This thesis presents ... -
Understanding regional diversity in the human biliary tree through transcriptomic profiling of primary tissues and in vitro derived organoids
(2019-01-26)The biliary tree is a series of ductular tissues responsible for the drainage of bile produced by the liver and pancreatic secretions from the pancreas. The biliary tree is affected by a diversity of life- threatening ...
