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Recent Submissions

  • Mitochondrial Respiration Is Reduced in Atherosclerosis, Promoting Necrotic Core Formation and Reducing Relative Fibrous Cap Thickness. 

    Yu, Martin Richard; Reinhold, Johannes; Yu, Haixiang; Starks, Lakshi; Uryga, Anna Katarzyna; Foote, Kirsty; Finigan, Alison et al. (2017-12)
    Objective: Mitochondrial DNA (mtDNA) damage is present in murine and human atherosclerotic plaques. However, whether endogenous levels of mtDNA damage are sufficient to cause mitochondrial dysfunction, and whether decreasing ...
  • Genome editing reveals a role for OCT4 in human embryogenesis. 

    Fogarty, Norah ME; McCarthy, Afshan; Snijders, Kirsten E; Powell, Benjamin E; Kubikova, Nada; Blakeley, Paul; Lea, Rebecca et al. (Springer Nature, 2017-10)
    During early human development, the totipotent zygote differentiates into a blastocyst comprised of pluripotent epiblast cells, which form the fetus, and extra-embryonic cells that contribute to the placenta and yolk sac. ...
  • Neuronal Cell Death. 

    Fricker, Michael; Tolkovsky, Abby Miriam; Borutaite, Vilmante; Coleman, Michael Philip; Brown, Guy C (2018-04)
    Neuronal cell death occurs extensively during development and pathology, where it is especially important because of the limited capacity of adult neurons to proliferate or be replaced. The concept of cell death used to ...
  • New models to study vascular mural cell embryonic origin: implications in vascular diseases. 

    Sinha, Sanjay; Santoro, Massimo Mattia (Elsevier, 2018-03)
    A key question in vascular biology is how the diversity of origin of vascular mural cells, namely smooth muscle cells and pericytes influences vessel properties, in particular the regional propensity to vascular diseases. ...

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