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  • Dietary pectic glycans are degraded by coordinated enzyme pathways in human colonic Bacteroides. 

    Luis, Ana S; Briggs, Jonathon; Zhang, Xiaoyang; Farnell, Benjamin; Ndeh, Didier; Labourel, Aurore; Baslé, Arnaud et al. (Nature, 2018-02)
    The major nutrients available to human colonic Bacteroides species are glycans, exemplified by pectins, a network of covalently linked plant cell wall polysaccharides containing galacturonic acid (GalA). Metabolism of ...
  • SRSF3 maintains transcriptome integrity in oocytes by regulation of alternative splicing and transposable elements 

    Dang Do, Vinh; Strauss, Bernhard; Cukuroglu, Engin; Macaulay, Iain; Boon Wee, Keng; Xiamoming, Tim; Ruiz De Los Mozos, Igor et al.
    The RNA-binding protein SRSF3 (also known as SRp20) has critical roles in the regulation of pre-mRNA splicing. Zygotic knockout of Srsf3 results in embryo arrest at the blastocyst stage. However, SRSF3 is also present in ...
  • Sub-minute kinetics of human red cell fumarase: 1 H spin-echo NMR spectroscopy and 13 C rapid-dissolution dynamic nuclear polarization. 

    Shishmarev, Dmitry; Wright, Alan J; Rodrigues, Tiago B; Pileio, Giuseppe; Stevanato, Gabriele; Brindle, Kevin Michael; Kuchel, Philip W (Wiley-Blackwell, 2018-03)
    Fumarate is an important probe of metabolism in hyperpolarized magnetic resonance imaging and spectroscopy. It is used to detect the release of fumarase in cancer tissues, which is associated with necrosis and drug treatment. ...
  • The RNA-binding protein PTBP1 is necessary for B cell selection in germinal centers. 

    Monzón-Casanova, Elisa; Screen, Michael; Díaz-Muñoz, Manuel D; Coulson, Richard MR; Bell, Sarah E; Lamers, Greta; Solimena, Michele et al. (Springer Nature, 2018-01-22)
    Antibody affinity maturation occurs in germinal centers (GCs), where B cells cycle between the light zone (LZ) and the dark zone. In the LZ, GC B cells bearing immunoglobulins with the highest affinity for antigen receive ...

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