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Recent Submissions

  • Polyethylene bio-degradation by caterpillars of the wax moth Galleria mellonella 

    Bombelli, P; Howe, CJ; Bertocchini, F (Cell Press, 2017-04-24)
    Plastics are synthetic polymers derived from fossil oil and largely resistant to biodegradation. Polyethylene (PE) and polypropylene (PP) represent ∼92% of total plastic production. PE is largely utilized in packaging, ...
  • Flexible tethering of primase and DNA Pol α in the eukaryotic primosome 

    Núñez-Ramírez, R; Klinge, S; Sauguet, L; Melero, R; Recuero-Checa, MA; Kilkenny, M; Perera, RL et al. (Oxford University Press, 2011-10)
    The Pol α/primase complex or primosome is the primase/polymerase complex that initiates nucleic acid synthesis during eukaryotic replication. Within the primosome, the primase synthesizes short RNA primers that undergo ...
  • Structural and functional insights into DNA-end processing by the archaeal HerA helicase-NurA nuclease complex 

    Blackwood, JK; Rzechorzek, NJ; Abrams, AS; Maman, JD; Pellegrini, L; Robinson, NP (Oxford University Press, 2011-12-01)
    Helicase-nuclease systems dedicated to DNA end resection in preparation for homologous recombination (HR) are present in all kingdoms of life. In thermophilic archaea, the HerA helicase and NurA nuclease cooperate with the ...
  • Insights into Fanconi Anaemia from the structure of human FANCE 

    Nookala, RK; Hussain, S; Pellegrini, L (Oxford University Press, 2007-02-18)
    Fanconi Anaemia (FA) is a cancer predisposition disorder characterized by spontaneous chromosome breakage and high cellular sensitivity to genotoxic agents. In response to DNA damage, a multi-subunit assembly of FA proteins, ...

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