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  • PPP1R15A-mediated dephosphorylation of eIF2$\alpha$ is unaffected by Sephin1 or Guanabenz 

    Crespillo-Casado, A; Chambers, JE; Fischer, PM; Marciniak, SJ; Ron, D (eLife Sciences Publications Ltd, 2017-04-27)
    Dephosphorylation of translation initiation factor 2 (eIF2$\alpha$) terminates signalling in the mammalian integrated stress response (ISR) and has emerged as a promising target for modifying the course of protein misfolding ...
  • TriPer, an optical probe tuned to the endoplasmic reticulum tracks changes in luminal H$_2$O$_2$ 

    Melo, EP; Lopes, C; Gollwitzer, P; Lortz, S; Lenzen, S; Mehmeti, I; Kaminski, CF et al. (BioMed Central, 2017-03-27)
    $\textbf{Background:}$ The fate of hydrogen peroxide (H$_2$O$_2$) in the endoplasmic reticulum (ER) has been inferred indirectly from the activity of ER-localized thiol oxidases and peroxiredoxins, in vitro, and the ...
  • Signalling in the gut endocrine axis 

    Gribble, FM; Reimann, F (Elsevier, 2017-02-28)
    Enteroendocrine cells are sensory cells located in the intestinal epithelium that produce a variety of hormonal regulators of gastrointestinal physiology, metabolism and food intake. They detect the absorption of a wide ...
  • Genetics of obesity: can an old dog teach us new tricks? 

    Yeo, GSH (Springer, 2017-05-01)
    At one level, obesity is clearly a problem of simple physics, a result of eating too much and not expending enough energy. The more complex question, however, is why do some people eat more than others? Studies of human ...

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