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  • Genetics of obesity: can an old dog teach us new tricks? 

    Yeo, GSH (Springer, 2016-12-24)
    At one level, obesity is clearly a problem of simple physics, a result of eating too much and not expending enough energy. The more complex question, however, is why do some people eat more than others? Studies of human ...
  • FICD acts bifunctionally to AMPylate and de-AMPylate the endoplasmic reticulum chaperone BiP 

    Preissler, S; Rato, C; Perera, LA; Saudek, V; Ron, D (Nature Publishing Group, 2017-01-01)
    Protein folding homeostasis in the endoplasmic reticulum (ER) is defended by an unfolded protein response that matches ER chaperone capacity to the burden of unfolded proteins. As levels of unfolded proteins decline, a ...
  • Paradoxical Sensitivity to an Integrated Stress Response Blocking Mutation in Vanishing White Matter Cells 

    Sekine, Y; Zyryanova, A; Crespillo-Casado, A; Amin-Wetzel, N; Harding, HP; Ron, D (Plos One, 2016-11-03)
    The eukaryotic translation initiation factor eIF2B promotes mRNA translation as a guanine nucleotide exchange factor (GEF) for translation initiation factor 2 (eIF2). Endoplasmic reticulum (ER) stress-mediated activation ...
  • The Sleep/Wake Cycle Is Directly Modulated by Changes in Energy Balance 

    Collet, Tinh-Hai; van der Klaauw, Agatha A.; Henning, Elana; Keogh, Julia M.; Suddaby, Diane; Dachi, Sekesai V.; Dunbar, Síle et al. (Associated Professional Sleep Societies, LLC, 2016-09-01)
    $\textbf{Study Objectives:}$ The rise in obesity has been paralleled by a decline in sleep duration in epidemiological studies. However, the potential mechanisms linking energy balance and the sleep/wake cycle are not well ...

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