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Recent Submissions

  • Glioma-induced inhibition of caspase-3 in microglia promotes a tumor-supportive phenotype 

    Shen, X; Burguillos, MA; Osman, AM; Frijhoff, J; Carrillo-Jiménez, A; Kanatani, S; Augsten, M et al. (Nature Publishing Group, 2016-11)
    Glioma cells recruit and exploit microglia (the resident immune cells of the brain) for their proliferation and invasion ability. The underlying molecular mechanism used by glioma cells to transform microglia into a ...
  • Spatio-temporal activation of caspase-8 in myeloid cells upon ischemic stroke 

    Rodhe, J; Burguillos, MA; de Pablos, RM; Kavanagh, E; Persson, A; Englund, E; Deierborg, T et al. (BioMed Central, 2016-08-26)
    Ischemic stroke (caused by thrombosis, embolism or vasoconstriction) lead to the recruitment and activation of immune cells including resident microglia and infiltrating peripheral macrophages, which contribute to an ...
  • Advanced monitoring in traumatic brain injury: microdialysis 

    Carpenter, KLH; Young, AMH; Hutchinson, PJ (Wolters Kluwer, 2017-04-01)
    Purpose of review: Here, we review the present state-of-the-art of microdialysis for monitoring patients with severe traumatic brain injury, highlighting the newest developments. Microdialysis has evolved in neurocritical ...
  • NMN Deamidase Delays Wallerian Degeneration and Rescues Axonal Defects Caused by NMNAT2 Deficiency In Vivo 

    Di Stefano, M; Loreto, A; Orsomando, G; Mori, V; Zamporlini, F; Hulse, RP; Webster, J et al. (Elsevier (Cell Press), 2017-03-20)
    Axons require the axonal NAD-synthesizing enzyme NMNAT2 to survive. Injury or genetically induced depletion of NMNAT2 triggers axonal degeneration or defective axon growth. We have previously proposed that axonal NMNAT2 ...

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