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Recent Submissions

  • Rapid identification of genes controlling virulence and immunity in malaria parasites 

    Abkallo, HM; Martinelli, A; Inoue, M; Ramaprasad, A; Xangsayarath, P; Gitaka, J; Tang, J et al. (PLOS, 2017-07-12)
    Identifying the genetic determinants of phenotypes that impact disease severity is of fundamental importance for the design of new interventions against malaria. Here we present a rapid genome-wide approach capable of ...
  • Anteroposterior polarity and elongation in the absence of extraembryonic tissues and spatially localised signalling in Gastruloids, mammalian embryonic organoids 

    Turner, David Andrew; Girgin, M; Alonso-Crisostomo, L; Trivedi, Vikas; Baillie-Johnson, Peter; Glodowski, CR; Hayward, Penelope Caroline et al.
    The establishment of the anteroposterior (AP) axis is a critical step during animal embryo development. In mammals, genetic studies have shown that this process relies on signals spatiotemporally deployed in the extraembryonic ...
  • Plk4 and Aurora A cooperate in the initiation of acentriolar spindle assembly in mammalian oocytes 

    Bury, L; Coelho, Paula Maria; Simeone, A; Ferries, S; Eyres, CE; Eyres, PA; Zernicka-Goetz, M et al.
    Establishing the bipolar spindle in mammalian oocytes after their prolonged arrest is crucial for meiotic fidelity and subsequent development. In contrast to somatic cells, the first meiotic spindle assembles in the absence ...
  • Modeling of axonal endoplasmic reticulum network by spastic paraplegia proteins 

    Yalçın, B; Zhao, Lu; Stofanko, M; O'Sullivan, NC; Kang, ZH; Roost, A; Thomas, MR et al.
    Axons contain a smooth tubular endoplasmic reticulum (ER) network that is thought to be continuous with ER throughout the neuron; the mechanisms that form this axonal network are unknown. Mutations affecting reticulon or ...

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