Scholarly Works - Haematology
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Assessing the reliability of spike-in normalization for analyses of single-cell RNA sequencing data. (Cold Spring Harbor Laboratory Press, 2017-11)By pro ling the transcriptomes of individual cells, single-cell RNA sequencing provides unparalleled resolution to study cellular heterogeneity. However, this comes at the cost of high technical noise, including cell-spec ...
Thrombopoietin signaling to chromatin elicits rapid and pervasive epigenome remodeling within poised chromatin architectures. (Cold Spring Harbor Laboratory Press, 2018-02-02)Thrombopoietin (TPO) is a critical cytokine regulating hematopoietic stem cell maintenance and differentiation into the megakaryocytic lineage. However, the transcriptional and chromatin dynamics elicited by TPO signaling ...
(2018-03-30)The integrated stress response (ISR) is a conserved translational and transcriptional program affecting metabolism, memory, and immunity. The ISR is mediated by stress-induced phosphorylation of eukaryotic translation ...