Scholarly Works - Haematology
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Recent Submissions
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Real-space refinement in PHENIX for cryo-EM and crystallography.
(International Union of Crystallography (IUCr), 2018-06-01)This article describes the implementation of real-space refinement in the phenix.real_space_refine program from the PHENIX suite. The use of a simplified refinement target function enables very fast calculation, which in ... -
Branched-chain amino acid depletion conditions bone marrow for hematopoietic stem cell transplantation avoiding amino acid imbalance-associated toxicity.
(Elsevier BV, 2018-07)Hematopoietic stem cells (HSCs) are used clinically in bone marrow (BM) transplantation due to their unique ability to reform the entire hematopoietic system. Recently, we reported that HSCs are highly sensitive to valine, ... -
Exploiting distant homologues for phasing through the generation of compact fragments, local fold refinement and partial solution combination.
(International Union of Crystallography (IUCr), 2018-04-01)Macromolecular structures can be solved by molecular replacement provided that suitable search models are available. Models from distant homologues may deviate too much from the target structure to succeed, notwithstanding ... -
Critical Modulation of Hematopoietic Lineage Fate by Hepatic Leukemia Factor.
(Elsevier BV, 2017-11-21)A gradual restriction in lineage potential of multipotent stem/progenitor cells is a hallmark of adult hematopoiesis, but the underlying molecular events governing these processes remain incompletely understood. Here, we ...
